In the energy transfer field, non-Newtonian fluid flow has an inclusive range of applications in the movement of biological fluids, oceanography, coating energy exchanger technology, melt-spinning, and the cooling of metallic plates and suspensions. Given these applications, this study examines the numerical simulation of hydromagnetic non-Newtonian Maxwell fluid flow on a horizontal plate through a porous medium. The numerical investigation of the current mathematical model is analyzed by taking the impact of magnetohydrodynamics (MHD), porous, radiation, energy generation, and Soret/Dufour with a thermal slip boundary condition. Partial differential equations with nonlinearities are transformed into ordinary differential equations by using similarity variables. The eminent numerical Runge-Kutta-Fehlberg fourth order via inbuilt software bvp4c in MATLAB and entropy generation analysis are used to determine the solution to the equations. Results were discussed via plots for Soret/Dufour effects for temperature, concentration, Nusselt number, and Sherwood number profiles. The fundamental goal and novelty of this study are to find the Bejan number (Be) and total entropy generation (<i>N</i><sub>s</sub>) for the parameters MHD, Reynold number (Re), radiation parameter (Rd), dimensionless temperature, and concentration ratio variables. We validated our code with existing work and obtained good matching. The difficult findings of this investigation are that the <i>N</i><sub>s</sub> profile surges for Re, Rd, porous, and MHD parameters but decreases for the dimensionless temperature ratio variable, and the Be profile increases for all the abovementioned parameters.