Large ignimbrites are the product of devastating explosive eruptions that have repeatedly impacted climate and life on global scale. The assemblage of vertical and lateral lithofacies variations within an ignimbrite sheet, its internal architecture, may help to determine how the parental pyroclastic current evolves in time and space. The 39 ka Campanian Ignimbrite eruption, vented from Campi Flegrei caldera, laid down a thick ignimbrite over an area of thousands of km2. A detailed reconstruction of the vertical and lateral variation of the seven lithofacies recognised in the ignimbrite medial sequence constrains the behaviour of this event. The pyroclastic current flowed over a wide area around Campi Flegrei without depositing (bypass zone), and inundated a huge area during most of the paroxysmal, waxing phase, emplacing a mainly incipiently- to strongly- welded ignimbrite. Following this waxing phase, the leading edge of the current retreated back towards the source as the current waned, impacting a progressively smaller area and leaving an unconsolidated ash and lapilli deposit, later lithified. Our study illustrates how large pyroclastic currents can evolve in time and space and the importance of both internal (eruptive and transport mechanisms) and external (topography, surficial water and rain) factors in governing their behaviour.