The development of hard-to-recover reserves every year requires ever-more-innovative industrial and laboratory approaches for efficient production of hydrocarbons. Oil industry has recently turned to the use of microfluidic technology to investigate the flow paths and interactions of reservoir fluids under high pressures and temperatures. The present study describes elaboration of a digital core on a chip, i.e. a microfluidic chip with the structure that replicates the void space of a selected reservoir and is designed based on the computed tomography images of core samples. Similarity of core samples and 2D generated structure was controlled through average pore diameter and structure morphology. The manufactured micromodels were used for surfactant compositions screening aiming to demonstrate the technology capabilities for further testing of various enhanced oil recovery (EOR) chemicals.Thus, several surfactants were examined in bulk employing standard screening procedures (stability evaluation, interfacial tension (IFT) measurements and phase behavior test with oil), and then were investigated in transparent microfluidic chips. Visualization of fluid flow in the porous structure is a primary advantage of microfluidics application for EOR. Hence, surfactant coreflooding-on-a-chip enabled correlation of IFT behavior of various surfactants with recovery efficiency, fast detection of in-situ emulsification and fluid flow distribution analysis in the porous media. Generally, symbiosis of two advanced technologies, i.e. microfluidics and digital core modeling, facilitated significant speed up of laboratory tests and reduce of their cost.