With the development of industrial technology, the demand for health diagnosis and maintenance of centrifugal pumps is becoming increasingly urgent. Combining digital twin and machine vision technology, this paper proposes an intelligent diagnosis method for centrifugal pump impeller machinery fault based on digital twin flow field cloud map. Firstly, the centrifugal pump digital twin model is used to simulate the evolution of random fracture fault of impeller blades, and the impeller flow field pressure and velocity cloud maps with different fault characteristics are generated; secondly, based on the learning and training of Yolov5 algorithm, two types of machine vision models of pressure and velocity cloud maps are obtained, and the preliminary diagnosis of impeller faults is realized by combining statistical analysis; then, considering the complementary advantages of the two types of detection models, the two are integrated based on the idea of stacking integration to improve the accuracy of impeller fault diagnosis. Experimental verification shows that for random fracture faults of impeller blades, the centrifugal spring intelligent fault diagnosis method proposed in this paper can achieve a diagnostic accuracy of more than 0.99, and the developed intelligent diagnosis system for centrifugal pump impeller machinery faults enables the method in this paper to be put into practice.