ABSTRACT The forces and motion state of particles within the fluid domain of the Knelson concentrator have long been a focal point for researchers. Presently, Stokes’ flow laws are commonly employed as the basis for theoretical calculations. However, this approach somewhat deviates from reality due to challenges in determining the Reynolds number of particles in the centrifugal force field during practical work. Additionally, the relationship between the Reynolds number and the drag coefficient remains undetermined in certain ranges. This study presents a high predictive relationship curve, obtained using fitting software, to supplement and rectify the limitations in the existing relationship. Leveraging fluid simulation software, this research determines the Reynolds number of particles of different sizes and densities within the fluid, offering a methodological reference for similar flow field problems. A new drag coefficient function is proposed and validated for the Reynolds number range of 1 to 20, addressing a gap in existing theoretical models. The simulation results indicate that under the suitable separation conditions of −0.074 + 0.02 mm particles, the concentrate particles overcome the flushing effect of the reverse washing water and move in the opposite direction to the fluid. This advancement not only improves the theoretical framework but also offers significant academic and practical value by enhancing the efficiency of particle separation in the Knelson concentrator.