Soil erosion and sediment transport are significant concerns in the Yaqui River sub-basin in northwest Mexico, driven by land use changes and environmental degradation. This study aims to evaluate erosion processes between 2000 and 2020 using a combination of satellite imagery and numerical simulations with Iber software (Version 2.5.2). The primary objective is to assess the impacts of land use changes, particularly the conversion of forest to grassland, on erosion rates and sediment transport. Satellite images from 2000 and 2020 were analyzed to detect land cover changes, while Iber’s sediment transport module was used to simulate erosion patterns based on the Meyer–Peter and Müller equation for bedload transport. Hydrological and topographical data were incorporated to provide accurate simulations of flow velocity, depth, and erosion potential. The results reveal a 35.3% reduction in forest cover, leading to increased erosion and sediment transport in steep areas. Simulation predictions highlighted areas with high future erosion potential, which are at risk of further soil loss if current trends continue. Flow velocity increased, contributing to riverbank destabilization and higher sediment yield, posing a risk to infrastructure such as the Álvaro Obregón Dam. This study underscores the need for targeted erosion control measures and sustainable land management practices to mitigate future risks and protect vital infrastructure in the Yaqui River Basin.