In order to solve the problems of difficult and inaccurate cavitation simulation in centrifugal pumps, this paper adopts the commercial software CFX and realizes the same-platform comparison of Zwart-Gerber-Belamri model, Kunz model and Schner-Saer model in the simulation of centrifugal pumps’ cavitation by using its own language. The research results show that the Schner-Saer model can predict the external characteristics of the pump more accurately without considering the coefficient correction; By adjusting the empirical coefficients, different cavitation models can achieve the same effect; The Kunz model can predict the pressure distribution in the impeller more accurately, and the error is basically kept within 10% except for the local complex flow area; The change of the pump head is more obviously affected by the volume of the vapour in impeller, but weakly affected by the morphology of the vapour.