To evaluate the morphology of sella turcica (ST) in individuals with different skeletal malocclusions in upper Egypt. 300 lateral cephalometric radiographs of adult patients of both sexes, varying ages from 18 to 30 years, were selected and divided into three equal groups, group (1): skeletal class I (control group), group (2): skeletal class II, and group (3): skeletal class III. Pre-treatment lateral cephalograms were taken from the archives of the Department of Orthodontics, Faculty of Dentistry, Minia University. The tuberculum and dorsum sella, the floor of ST, and posterior and anterior clinoid processes (ACPs) were drawn. The direct measurements such asdiameter (APD), depth (D), and length(L) of sella were measured using Silverman and Kisling methods. A significant difference was found in depth (D) between class I and class II, with class II having a greater depth.Also, the largest diameter (APD) was found in the class III group.A significant difference was found in diameter (APD) between the two age groups (from 18 to 24 years and from 25 to 30 years) Conclusion: The larger diameter values were seen in the skeletal class III subjects, while the larger depth values were observed in the class II subjects. The older age group (25-30 years) has a greater diameter than the younger one. Highly significant differences were found in length and depth between the sexes.