Extreme events like floods are a concern for any country in terms of the damages caused to life as well as property. The recent trend of unpredictable rainfall in India leads to significant changes in the flow of the river and basin characteristics, which contribute to the aggravation of floods. In the cataclysmic flood in the year 2018 in Kerala, the Chalakudy river basin was completely inundated. This region has undergone extensive environmental changes since the 1990s due to agricultural expansion, deforestation, increased urbanization etc. These indicate the need for conducting a hydrologic and land use/land cover (LULC) change analysis to identify the causes, effects and solutions to mitigate the devastating effect of floods. This goal is achieved with the help of Geographic Information System (ArcGIS) and a hydrological model (HEC-HMS). The results from the study shows that tremendous change in land use pattern has occurred over the past few decades and the notable among them is the 1003.9% increase in built-up area. The increase in flood peak of the devastating Kerala Flood 2018, exclusively due to this land use change/urbanization is found to be about 22% in this study area.