AbstractClimate change has remarkably intensified the occurrence of floods around the globe. Flooding causes loss of life and property. Flood frequency analysis (FFA) is an important investigation and plays a key role in flood‐related studies. Geographically, the study area is confined in the lower Brahmaputra floodplains, flat slope, and rivers are braided in nature. Because of Heavy rainfall, major rivers in the area carry huge influxes of surged water during the summer period. Hence, disastrous flooding can be seen every year in the study region. The present study aims to model flood frequency using the hydrological data to understand the effects within the area. FFA approaches like Gumbel, Log Pearson type 3 (LP‐3), and Log‐Normal (LN) were used, and comparative analyses were done using water level data for the Manas, Aie, and Brahmaputra Rivers. Moreover, remote sensing and the geographic information system (GIS) environment were used to generate FFA‐based flood predictive inundation map at 5, 10, 50, 100, and 200 years of return periods. Here, Gumbel's distribution has found the best fit for all the rivers among the three. The distribution reveals that at a 200‐year return period, the highest water level would be increased by 1.45, 2.41, and 4 m for the Manas, Aie, and Brahmaputra Rivers, respectively. The study shows that almost 493.54 and 673.72 km2 of areas are expected to be submerged at 5 and 200‐year return periods according to Gumbel's distribution; LP‐3 distribution predicted 493.01 and 555.66 km2, and the log‐normal distribution method predicted 432.51 and 555.74 km2 of flood‐sensitive areas at 5 and 200‐year return periods, respectively. The FFA highlighted spatio‐temporal effects on the expansion of submerged areas. We hope that the findings of the present study will aid in the different flood hazard management strategies for future endeavors.