Floods are the most common natural hazards causing damage to properties and loss of life worldwide. They are not preventable but vulnerability assessments, hazard mitigation, and effective emergency management plans can reduce their impacts and facilitate recovery actions. Floods can have different impacts depending on the local physical conditions and on the social context represented by the economic and cultural patterns of a specific community. Social vulnerability is the susceptibility of social groups to the adverse impacts of natural hazards, including disproportionate death, injury, loss, or disruption of livelihood. Therefore, the social vulnerability analysis becomes of primary importance in understanding the main factors influencing the capacity of a specific community to anticipate, cope with, and recover from a flood event. In this context, this paper investigates the correlation between flood hazard and socio-economic factors across the Basilicata Region (southern Italy). The aim of this research is to evaluate flood hazard and social vulnerability index through a Geographic Information System (GIS) approach. Multivariate factor analysis was applied in this work to construct an overall social vulnerability index which was combined with the flood hazard distribution. Our results underline the presence of 107,587 people with a high level of both flood hazard and social vulnerability.