In this study, a hydrodynamics-based structural response analysis procedure of supporting frames for multiconnected offshore floating photovoltaics (FPVs) is suggested. Based on the suggested simulation methodology, the dynamic behavioral characteristics of the system were investigated. First, rational mooring types for FPVs installed in the inner harbor were studied based on the analysis results. Subsequently, extensive parametric studies have been conducted to determine a rational design strategy for dynamic response mitigation. In this study, the effects of the initial configuration and axial stiffness of taut mooring lines, arrangement angles of FPV systems, and floater dimensions on the static and dynamic responses of supporting frames under irregular waves in the inner harbor were studied. The corner module in the multiconnected system showed critical responses among others, the investigation of which is required for safety evaluation. Furthermore, it was observed that the mooring stiffness governed the overall stiffness of the system, which was proportional to the mitigation of the dynamic responses. Finally, the unsupported length of the frame, which was defined by the floater size, was found to be the key parameter for the mitigation of structural responses.