Objective To investigate the application effect of flipped teaching mode on defibrillator training and compare with traditional training mode. Methods A total of 60 nurses were selected from a certain top-three hospital of Guangzhou with numbers. In addition, random number table method was used to divide into groups, where 30 nurses were in flipped teaching group and traditional training group respectively.Before and after intervention, theory and operation examinations were conducted to the two groups of nurses uniformly.After intervention, the recognition degrees of two groups to their teaching modes were investigated. t examination and χ2examination were applied to compare the difference of groups before and after intervention, the percent of pass, score and recognition degrees of two groups after intervention.Finally, Kaplan-Meier was used to have survival analysis on the examined percent of pass of two groups and describe the extinction of two groups. Results Before intervention, with regard to the comparison between percent of pass and score of two examined groups, the difference had no statistical significance(P>0.05). After intervention, the difference of theoretical examination percent of pass of two groups had no statistical significance(P>0.05). However, the scoring comparison difference had statistical significance(P<0.05). With regard to the comparison between percent of pass and score of two technical examination groups, the difference had statistical significance(P<0.05). The comparison difference of recognition degree investigation of two groups had statistical significance(P<0.05). It was tested by Log Rank (Mantel-Cox) method that the survivorship curve comparison of two groups had statistical significance(P<0.05). Conclusion Compared with traditional training mode, flipped teaching mode can improve the scoring level of defibrillator theory for the nurses, and the percent of pass and scoring level of operation.In addition, it's highly recognized by nurses.Moreover, it can delay the extinction time of examination percent of pass of defibrillator so as to delay recurrent training period, which is worth having popularization and application. Key words: Defibrillator; Flipped classroom teaching; Acceptance-rate; Survival analysis