The interaction between a thin plate (kH≲1, k being the wavenumber and H the plate thickness) and a compressible fluid half-space through a slightly rough boundary may be represented by the standard thin plate equations plus a smoothed boundary condition for the displacement of the fluid normal to the plate. This replaces the rough boundary by a fictitious smooth plane at which the relation ∂φs/∂z =ηφ1 must be obeyed, where φs is the perturbation of the smooth boundary solution due to roughness, φ1 is the total acoustic potential in the fluid at the smooth plane z=0, and η is a constant which, for isotropic roughness or for corrugations, is defined by two scatter parameters. This condition is isomorphic to those used for other types of rough interfaces [I. Tolstoy, J. Acoust. Soc. Am. 75, 1–22 (1984)]—the main difference residing in the numerical values of the parameters. The most important effects are connected with the flexural modes of the plate. Here, the roughness causes energy losses into incoherent acoustic scatter and introduces an important level of attenuation. Harmonic point source solutions are obtained for several types of interface roughness, showing that, for moderate and large ranges r (kr≳102), this effect introduces an effective cutoff frequency for κh≲1, κ being the horizontal wavenumber of the flexural waves and h the spacing between the bosses (or corrugations of the roughness model). The effect of the roughness on the flexural wave dispersion is of the order of several percent, and should be measurable for plates of relatively low flexural rigidity.