Flexor Tendon Injuries Research Articles

Neglected flexor tendon injury for 10 years, un-usual finding and one stage repair without free tendon graft: Case report.

IntroductionIn delayed or neglected cases of flexor tendon injury, reconstruction of flexor digitorum profundus (FDP) is usually performed using free tendon graft due to the retraction of tendon ends and shortening of the tendon. Flexor digitorum superficialis (FDS), palmaris longus or plantaris tendons can be used as a free tendon graft [1–3].Presentation of caseThis is a case report of female patient 17 years old with neglected cut of her left Ring finger's FDP and FDS tendons zone II with suspected concomitant digital nerve injury, the injury was neglected for 10 years in the patient's non-dominant hand.DiscussionUpon exploration unusual finding of spontaneous healing of the proximal stumps of FDS and FDP tendons raised the idea of doing the repair one stage without free graft by using pedicled intra-synovial graft from the sublimis tendon to reconstruct the FDP tendon.The patient after 4 months follow-up and after completion of the physiotherapy program regained the ability to actively flex her finger to near full flexion with improved function and cosmesis.ConclusionDelayed flexor tendon reconstruction in neglected cases is still offering good results even after long periods of delay provided that the finger's joints are still supple and mobile.

Patient outcomes and costs after isolated flexor tendon repairs of the hand

BackgroundAcute flexor tendon injuries are challenging injuries for patients, surgeons, and therapists alike. There is ongoing debate about the optimal timing and amount of therapy after these injuries. PurposeWe sought to investigate the relationship between hand therapy utilization and reoperation rates after flexor tendon repair and quantify reoperation rates and costs associated with flexor tendon repair. We hypothesize there will be an inverse relationship between the number of hand therapy visits and later reoperation rates and a positive correlation between reoperation rates and total cost of care. Study DesignA retrospective cohort study of patients undergoing primary flexor tendon repair was pursued. MethodsA commercially available database was utilized to access insurance claims data for 20.9 million patients in the US from 2007 to 2015. Patients undergoing primary flexor tendon repair were included and followed for one year. Patients with fractures, vascular injuries, or digit replantation were excluded. We studied post-operative rehabilitation utilization, reoperation rates, and costs. Chi-Square tests and multivariable logistic regressions were used to assess the relationship between therapy utilization and reoperation rates and costs. ResultsThe one-year reoperation rate was 11.4 percent at a median time of 100.0 days amongst 1,129 patients undergoing primary tendon repair. In multivariable analysis, age between 30 and 59, male sex, and utilization of over 21 therapy sessions were associated with increased odds of reoperation. Mean insurance reimbursement one year following primary flexor repair was $14,533 per patient but $27,870 if patients went on to reoperation. ConclusionContinued therapy utilization after primary flexor tendon repair is an independent predictor of reoperation need. These findings may help surgeons counsel patients who require a large number of visits after flexor tendon repair on when to revisit surgical options.

Rehabilitation following flexor tendon injury to the hand in African countries: a study protocol for a scoping review

Quality of life is enhanced by engagement in meaningful activities and participation using our hands. In African countries, people rely predominantly on the use of their hands to engage in...

Zonal characterization and differential trilineage potentials of equine intrasynovial deep digital flexor tendon-derived cells

BackgroundIntrasynovial deep digital flexor tendon (DDFT) injuries occur frequently and are often implicated in cases of navicular disease with poor outcomes and reinjuries. Cell-based approaches to tendon healing are gaining traction in veterinary medicine and ultimately may contribute to improved DDFT healing in horses. However, a better understanding of the innate cellular characteristics of equine DDFT is necessary for developing improved therapeutic strategies. Additionally, fibrocartilaginous, intrasynovial tendons like the DDFT are common sites of injury and share a poor prognosis across species, offering translational applications of this research. The objective of this study is to isolate and characterize tendon-derived cells (TDC) from intrasynovial DDFT harvested from within the equine forelimb podotrochlear bursa. TDC from the fibrocartilaginous and tendinous zones are separately isolated and assessed. Flow cytometry is performed for mesenchymal stem cell (MSC) surface markers (CD 29, CD 44, CD 90). Basal tenogenic, osteogenic and chondrogenic markers are assessed via quantitative real time-PCR, and standard trilineage differentiation is performed with third passage TDC from the fibrocartilaginous (fTDC) and tendinous (tTDC) zones of DDFT.ResultsLow-density plating isolated homogenous TDC populations from both zones. During monolayer passage, both TDC subpopulations exhibited clonogenicity, high in vitro proliferation rate, and fibroblast-like morphology. fTDC and tTDC were positive for MSC surface markers CD90 and CD29 and negative for CD44. There were no significant differences in basal tenogenic, osteogenic or chondrogenic marker expression between zones. While fTDC were largely restricted to chondrogenic differentiation, tTDC underwent osteogenic and chondrogenic differentiation. Both TDC subpopulations displayed weak adipogenic differentiation potentials.ConclusionsTDC at the level of the podotrochlear bursa, that potentially could be targeted for enhancing DDFT injury healing in horses were identified and characterized. Pending further investigation, promoting chondrogenic properties in cells administered exogenously into the intrasynovial space may be beneficial for intrasynovial tendon regeneration.

Pulley, Flexor, and Extensor Tendon Injuries of the Hand.

Tendon injuries represent the second most common injury of the hand (after fractures) and are a common scanning indication in radiology. Pulley injuries are very frequent in rock climbers with the A2 pulley the most commonly affected. Tendon and pulley injuries can be reliably evaluated using ultrasound (US) and magnetic resonance imaging (MRI). US can be postulated as a first-line imaging modality, allowing dynamic examination. MRI is essential for cases with ongoing diagnostic doubt post-US and also for preoperative pulley reconstruction assessment.

Transosseous Sutures in Tendon-to-Bone Repairs: the Role of the Epitendinous Suture

Background: Numerous transosseous fixation techniques for flexor tendon injuries in Zone 1 of the hand have been described in the literature. While relatively high maximal loads to failure are documented in different biomechanical experiments, several tests revealed a low 2 mm gapping resistance of the tendon-to-bone repairs. We therefore aimed to investigate the effect on gap formation adding a peripheral suture to an established transosseous fixation technique. In addition, we analyzed the influence of different suture materials (braided vs. non-braided) on the stability of the core suture. Method: A total of 30 porcine flexor digitorum profundus tendons were divided into 3 groups (n = 10 each) and repaired using the transverse intraosseous loop technique (TILT). In group 1 and group 2 the repairs were performed using PDS 3-0 or Ethibond 3-0, respectively. In group 3, a peripheral suture was added to the core suture (PDS 3-0) consisting of two figure-of-eight stitches with PDS 5-0. The biomechanical performance of the repaired tendons was analyzed using a standardized protocol. Results: The suture material and peripheral suture showed no effect on the ultimate failure load in our testing. However, the addition of a peripheral suture led to a statistically significantly higher 2 mm gap force when compared with the repair with a core suture only. Conclusion: In conclusion, addition of a palmar epitendinous suture to the transosseous core suture significantly increases the load to 2 mm gap formation in Zone 1 flexor tendon repairs and thus allows an immediate controlled mobilization.

Diagnosis and Surgical Principles in the Treatment of Acute Injuries of the Flexor Tendons of the Hand

Injuries to the flexor tendons of the wrist are a separate chapter in wrist surgery. Flexor tendon injuries still remain a challenge to ensure the patient's optimal outcome.
 A special problem in the exploration of hand injuries is the accurate assessment of whether there is an injury to one or more tendons, at what height the injury is, and whether it is accompanied by injury to other elements of the hand.
 On the volar side of the hand, both flexors of the fingers, superficial and deep, or just one of them, maybe injured. If the lesion is in the first zone depending on the severity of the injury, reinsertion or direct tenography is required.
 In the second zone, there are still ambiguous views on the reconstruction of the deep and superficial flexor, ie. whether the surface flexor needs to be reconstructed. Injury to the flexor tendons in the third zone requires careful exploration for possible injury to the neurovascular elements, and the fourth zone often requires the release of the carpal tunnel.
 In the most proximal zone of the flexor tendons, the fifth zone, injury to the main blood vessels of the hand and the nerves responsible for sensitive and motor innervation of the hand is possible.
 Each injury should be approached with careful preoperative examination, appropriate operative technique as well as postoperative rehabilitation in order to fully restore the function of the hand.

Significance of Ultrasound-Guided Approach to the Operative Repair of Zone 2 Flexor Tendon Injuries.

Significance of Ultrasound-Guided Approach to the Operative Repair of Zone 2 Flexor Tendon Injuries.

Getting Better Results in Flexor Tendon Surgery and Therapy.

SummaryRecently, better outcomes have been reported when up-to-date developments in flexor tendon surgery and therapy were followed. Slightly tensioned multistrand repairs, judicious venting of pulleys, and early active motion are widely accepted principles. In addition to these principles, tailoring of the repair according to intraoperative active movement with wide awake local anesthesia no tourniquet (WALANT) surgical setting is recommended for better results. We aimed to describe our up-to-date approach to flexor tendon surgery and therapy with the help of visual communication tools of this age. The ideal primary repair of flexor tendons, the management of delayed presentation flexor tendon injuries, the key steps to achieve better results with flexor tendon therapy, and the tele-rehabilitation experience during COVID-19 pandemic will be highlighted. Zone 2 flexor tendon injuries are the most demanding part and will be focused on.

Six Strand Repair and Early Range of Motion in Management of Flexor Tendon Injury

Ligament fixes with 6-strands withstand joined dynamic and inactive finger movements. The crack rate is lower with the utilization of multi-strand fixes contrasted and those after customary 2-strand fixes. In any case, no randomized Prospective clinical examinations have explored this specific inquiry. Strategy: We talked about the clinical consequences of flexor ligaments fix utilizing six-strand stitch procedure to fix flexor ligaments in 46 fingers of 22 patient. fingers were effectively activated promptly postoperative in a defensive brace. The follow – up period normal 12.7 months. Result:91% of cases accomplished great to brilliant outcomes dependent on Strickland assessment framework and break rate was 4% of the cases. Determination: The utilization of a solid, hole safe stitch procedure like the six strand twofold circle method utilized in the current examination followed by the use of early postoperative controlled movement restoration brings about 91 % superb and great postoperative scope of movement.

Flexor Tendon Injury and Repair. The Influence of Synovial Environment on the Early Healing Response in a Canine Model.

Environmental conditions strongly influence the healing capacity of connective tissues. Well-vascularized extrasynovial tendons typically undergo a robust wound-healing process following transection and repair. In contrast, avascular intrasynovial tendons do not mount an effective repair response. The current study tests the hypothesis that flexor tendons, as a function of their synovial environment, exhibit unique inflammatory, angiogenic, and metabolic responses to injury and repair. Flexor tendons present a distinct opportunity to test the study hypothesis, as they have proximal regions that are extrasynovial and distal regions that are intrasynovial. In an internally controlled study design, the second and fifth forepaw flexor tendons were transected and repaired in either the extrasynovial or the intrasynovial anatomical region. Histological, gene expression, and proteomics analyses were performed at 3 and 7 days to define the early biological events that drive synovial environment-dependent healing responses. Uninjured intrasynovial tendons were avascular, contained high levels of proteoglycans, and expressed inflammatory factors, complement proteins, and glycolytic enzymes. In contrast, extrasynovial tendons were well vascularized, contained low levels of proteoglycans, and were enriched in inflammation inhibitors and oxidative phosphorylation enzymes. The response to injury and repair was markedly different between the 2 tendon regions. Extrasynovial tendons displayed a robust and rapid neovascularization response, increased expression levels of complement proteins, and an acute shift in metabolism to glycolysis, whereas intrasynovial tendons showed minimal vascularity and muted inflammatory and metabolic responses. The regional molecular profiles of intact and healing flexor tendons revealed extensive early differences in innate immune response, metabolism, vascularization, and expression of extracellular matrix as a function of the synovial environment. These differences reveal mechanisms through which extrasynovial tendons heal more effectively than do intrasynovial tendons. To improve outcomes after operative repair, future treatment strategies should promote features of extrasynovial healing, such as enhanced vascularization and modulation of the complement system and/or glucose metabolism.

Rehabilitation following surgery for flexor tendon injuries of the hand.

Rehabilitation following surgery for flexor tendon injuries of the hand.

Nanoparticle-coated sutures providing sustained growth factor delivery to improve the healing strength of injured tendons

Tendon injuries are common diseases. The healing capacity of tendon is limited due to its special composition of extra-cellular matrix and hypocellularity and hypovascularity. The purpose of this study was to evaluate the effectiveness of nanoparticle-coated sutures carrying growth factors for accelerating tendon repair. A variety of experimental methods had been used to investigate the characteristics and therapeutic effects of the modified sutures. Nanoparticles could adhere uniformly to the surface of the suture through polydopamine. Even sutured in the tendon, most of nanoparticles were still remained on the surface of suture, and the loaded proteins could spread into the tendon tissues. In vivo study, the ultimate strength of repaired tendons treated with bFGF and VEGFA-releasing sutures was significantly greater than the tendons repaired with control sutures at multiple time-points, whether in the chicken model of flexor tendon injury or the rat model of Achilles tendon injury. At week 6, the adhesion score in the bFGF and VEGFA-releasing suture group was significantly lower than those of the control suture group. Tendon gliding excursion was significantly longer in the bFGF and VEGFA-releasing suture group than that in the control bare sutures. Work of digital flexion was significantly decreased in the bFGF and VEGFA-releasing suture group. In a word, we developed a platform for local and continuous delivery of growth factors based on the nanoparticle-coated sutures, which could effectively deliver growth factors to tissues and control the release of growth factors. This growth factors delivery system is an attractive therapeutic tool to repair injured tendons. Statement of significanceTendon rupture is a common clinical injury, due to the special character of the tendon with mainly extra cellular matrix and hypocellularity and hypovascularity, the healing capacity of the injured tendon is limited. In this study, nanoparticle-coated surgical sutures carrying growth factors were prepared to accelerate tendon repair. After treatment, bFGF and VEGFA loaded nanoparticle-coated sutures can significantly enhance tendon healing, and significantly improve tendon gliding function and effectively inhibit the formation of adhesion. Moreover, these nanoparticle-coated sutures have good biocompatibility and no obvious tissue reaction, which provides more guarantee for further clinical application. This is an attractive and promising approach that uses surgical suture as a growth factor delivery tool to repair tendon injury, which can simplify the treatment. And this kind of bioactive sutures may be applied to other tissue repair, such as muscle, nerve, intestinal canal, blood vessel, skin, and so on.

Chronic Collateral Sesamoidean Desmopathy in Draft Horses: Magnetic Resonance Imaging and Histopathological Findings

Desmopathy of the collateral sesamoidean ligament (CSL) is an unusual disorder in draft horses. This study records the magnetic resonance imaging (MRI) features of chronic CSL desmopathy in eight draft horses and confirms these features by histopathology. The recorded chronic CSL desmopathy has usually affected the forelimbs (100%) and commonly bilateral (62.5%). All horses showed positive proximal digital nerve block, positive front digital flexion test, and negative interphalangeal extension test. Radiography revealed no osseous abnormalities in all feet. MRI features of chronic CSL desmopathy included thickening of the ligament with increased moderate intensity in fast low-angle shot, T1 turbo spin echo, and proton density images in the affected part of the ligament. Chronic CSL desmopathy was concomitant with deep digital flexor tendon injury and distal sesamoidean impar desmitis. In most chronic cases of CSL desmopathy, heterogeneous signal intensities were seen with multiple foci of low signal intensities interlaced with increased moderate signal intensities of thickened CSL. Histopathology confirmed the MRI findings and revealed separated bundles and fascicles by septa of less organized and loose connective tissues containing fibroblasts and loose collagen fibers. Multifocal islands of cartilaginous metaplasia, mineralized areas, and dystrophic calcification were observed in the injured ligament. In conclusion, chronic CSL desmopathy may progress to cartilaginous metaplasia and dystrophic calcification. MRI is a beneficial diagnostic and prognostic tool for chronic CSL desmopathy, and histopathology is a gold standard to document the MRI findings associated with CSL dysmopathy in draft horses.

Supraretinacular endoscopic carpal tunnel release: A safe alternative method for treatment of carpal tunnel syndrome.

Supraretinacular endoscopic carpal tunnel release (SRECTR) is a technique in which an endoscope is inserted superficial to the flexor retinaculum through a subcutaneous tunnel. The benefits of this method include a clear view for the surgeon and absence of median nerve compression. Surgeons can operate with a familiar view of the flexor retinaculum and median nerve downward, similar to open surgery. This study aimed to investigate the learning curve for SRECTR, an alternate method for carpal tunnel release, and evaluate its complications and the functional outcomes using a disposable commercial kit. We examined the open conversion rates and complications associated with SRECTR in 200 consecutive patients performed by two surgeons. We compared the operative time operated by a single surgeon. We evaluated outcomes in 191 patients according to Kelly's grading system. Patients' mean follow-up period was 12.7 months. Nine patients required conversion to open surgery. There were no injuries to the nerves and tendons and no hematoma or incomplete dissection of the flexor retinaculum. The operative times varied between 11 and 34 minutes. We obtained the following results based on Kelly's grading of outcomes: excellent in 116, good in 59, fair in 13, and poor in 3 patients. We found no patients with neurapraxia, major nerve injury, flexor tendon injury, superficial palmar arch injury, and hematoma. Although there was a learning curve associated with SRECTR, we performed 200 consecutive cases without neurovascular complications. This method may be a safe alternative to minimally invasive carpal tunnel surgery.

Primena Hanterove proteze u rekonstrukciji fleksornih tetiva šake

Flexor tendon injuries, especially in zone 2, still present a surgical challenge, even in cases of recent injuries and early reconstruction. Today`s generally accepted attitude is, in obsolete cases, that the best functional results are achieved by reconstruction within two acts, with the silicone Hunter prosthesis used. In previous five years in our Department of Microsurgery and Reconstructive Surgery, we used this prosthesis in seven cases: six patients were male, and their average age was around 41.71 ± 13.52. In addition, there were four patients previously operated in other hospitals. Phalanx fractures, soft tissue defects, and neurovascular lesions were injuries associated with hand flexor tendons. The average time from the injury to the Hunter prosthesis application was 30.28 ± 23.96 weeks (10 to 86 weeks). When using this implant, the precise instructions of sterilization and installation procedure, given by manufacturer, must be followed. Absolute contraindications for the use of Hunter prosthesis are: presence of infection, insufficient circulation of the finger, destruction of the finger nerves and severe joint contractures. Risks during silicone implant placement are infection, fracture of prothesis, loosening, and dislocation. It is important to make the right decision when entering in this type of surgery. The final result may not often meet the patient's expectations and may worsen over time, requiring revision surgery.

Proceed with Caution: Mouse Deep Digit Flexor Tendon Injury Model.

Quantitative data detailing the gross anatomy, biomechanical characteristics, and microscopic structure of the deep digit flexor tendon (DDF) of the mouse hindpaw were obtained. Histological characterization of the DDF and the anatomy of the digit in the mouse hindpaw are detailed. Biomechanical testing determined the load-to-failure, stress, elastic modulus, and the site of tendon failure. In gross anatomy, the origins and insertions of the mouse deep digit flexor tendon are similar to those of the human digit, surrounded by a synovial sheath that is only 1- to 2-cells thick. A neurovascular network runs on each side of the digit outside the synovial sheath, but does not clearly penetrate it. The thickness of the DDF is 0.14 ± 0.03 mm and the width is 0.3 ± 0.03 mm. The thickness of the DDF is less than that of 9-0 nylon needle. The mean failure force of the deep flexor tendon was 2.79 ± 0.53N. The gross anatomy of the mouse hindpaw digit is similar to that of the human digit except for key differences seen in the synovial sheath and vascular supply. The dimensions of the mouse DDF make it challenging to create a clinically translatable repair model using currently available surgical techniques. Despite the similarities between the human and mouse anatomy, and the powerful basic science tools available in murine models, mice are an unreliable model for assessing flexor tendon injury and repair.

A prospective comparative study of pull-out suture technique versus modified Kessler technique in flexor tendon repair for Zone I and distal Zone II injuries

Background: Injuries to the hand are common, and poor functional outcomes can have significant long-term consequences affecting both work and social activities. Good outcomes following flexor tendon lacerations in hand are dependent on a sound surgical repair allowing early active mobilization. Aims and Objectives: The purpose of the study was to compare the clinical and functional outcomes of Zone I and distal Zone II flexor tendon repair using pull-out suture technique with two-strand modified Kessler method. Materials and Methods: This hospital-based prospective study was conducted in a tertiary hospital setup in Manipur for 2 years' duration from November 2018 to November 2020. The study was conducted on 26 patients with a total of 30 injured digits, which were then divided into two equal groups of cases and control. Group A included study cases and were treated with pull-out suture technique. Group B included 15 control cases and were treated with modified Kessler technique. Comparison was done between the two different techniques based on patient variables and outcome measured with total active motion (TAM) evaluation system of the American Society for Surgery of Hands. Statistical Analysis: Data collected were entered into the SPSS version 16. Descriptive analysis of baseline characteristics of both study and control groups was done. The final analysis was done using the Chi-square test and SPSS version 16. P < 0.05 was taken as significant. Results: In our comparative study, at the 3-month follow-up range of motion was measured and TAM was calculated. Among case group, 2 (13%) belonged to good and 13 (87%) belonged to fair category, whereas among control group, 2 (13%) belonged to good and 1 poor category, and 12 (80%) belonged to fair category. About 50%–75% of functional recovery by 3 months was obtained in 80% of the cases and 73% of the control group. Conclusion: The pull-out suture technique is a good option for the management of Zone I and distal Zone II flexor tendon injuries.

Effect of Time to Hand Therapy following Zone II Flexor Tendon Repair

Insurance claims from the Truven MarketScan Databases were used to evaluate outcomes after isolated zone II flexor tendon repairs between January 2009 and October 2015. Cohorts differing in time to hand therapy were compared to evaluate the impact on complications, reoperation, and number of therapy sessions. Secondary outcomes analyzed how the number of therapy sessions affected rates of reoperation. Hand therapy was identified in 82% of patients (N = 2867) following tendon reconstruction. Therapy initiation occurred within 1 week, 1-4 weeks, and after 4 weeks in 56%, 35%, and 9% of patients, respectively. Univariate analysis showed no difference in non-tendinous complications (27%, 30%, 29%; P = 0.29) or tendon rupture rates (13%, 13%, 10%; P = 0.42) within 90 days between cohorts. Multivariable analysis showed no difference in rates of tenolysis (6.3%, 6%, 4.4%; P > 0.01). In the early initiation cohort, >23 hand therapy sessions were associated with the highest rates of tenolysis (19%). Despite being a common fear of hand surgeons, early initiation of hand therapy was not associated with increased tendon rupture rates. Although delayed therapy is a concern for tendon scarring, it did not confer a higher risk of tenolysis. Complication rates do not appear to correlate with timing of hand therapy. Therefore, hand surgeons should promote early mobility following isolated flexor tendon injuries given the known functional outcome benefits.

Beyond the Core Suture: A New Approach to Tendon Repair.

Background:Despite significant improvements in zone II flexor tendon repair over the last 2 decades, function-limiting complications persist. This article describes 2 novel repair techniques utilizing flexor digitorum superficialis (FDS) autografts to buttress the flexor digitorum profundus (FDP) repair site without the use of core sutures. The hypothesis being that the reclaimed FDS tendon autograft will redistribute tensile forces away from the FDP repair site, increasing overall strength and resistance to gapping in Zone II flexor tendon injuries compared with the current clinical techniques.Methods:Two novel FDP repair methods utilizing portions of FDS have been described: (1) asymmetric repair (AR), and (2) circumferential repair. Ultimate tensile strength and cyclical testing were used to compare novel techniques to current clinical standard repairs: 2-strand (2-St), 4-strand (4-St), and 6-strand (6-St) methods. All repairs were performed in cadaveric sheep tendons (n = 10/group), by a single surgeon.Results:AR and circumferential repair techniques demonstrated comparable ultimate tensile strength to 6-St repairs, with all 3 of these techniques able to tolerate significantly stronger loads than the 2-St and 4-St repairs (P < 0.0001). Cyclical testing demonstrated that AR and circumferential repair were able to withstand a significantly higher total cumulative force (P < 0.001 and P = 0.0064, respectively) than the 6-St, while only AR tolerated a significantly greater force to 2-mm gap formation (P = 0.042) than the 6-St repair.Conclusion:Incorporating FDS as an autologous graft for FDP repair provides at least a comparable ultimate tensile strength and a significantly greater cumulative force to failure and 2-mm gap formation than a traditional 6-St repair.