Flexion Exercise Research Articles

PENERAPAN WILLIAM FLEXION EXERCISE, NEURODYNAMIC TENSION DAN NEURODYNAMIC SLIDER SEBAGAI UPAYA PENGURANGAN NYERI PUNGGUNG BAWAH DI KECAMATAN MOJOLABAN SUKOHARJO

Low Back Pain (LBP) or associated low back pain with stress/strain of back muscles, tendons, and ligaments that are usually felt after doing excessive activities, such as lifting heavy weights wrong, bending too long, standing/sitting too long with the position wrongly, lower back pain that arises can result in loss and interfere with work productivity. William flexion exercise is a type of exercise with the concept of spinal flexion Consists of seven sets, aims to reduce pain and provide stability on lower trunk. The purpose of this activity is to provide education to the people of Laban Kulon Village which aims to make the community understand how to handle it, how to prevent it, and how to avoid low back pain. The service activities carried out in Laban Kulon Village RT 02 RW 2 Laban, Mojolaban Sukoharjo on Sunday, March 20, 2022 went smoothly. Based on the results of previous observations and interviews, many residents complained of lower back pain due to their lifestyle and daily activities. The majority are farmers and labourers. The risk factors for myogenic low back pain are the habit of lifting weights too often, sitting and lying down for a long time, sleeping in an uncomfortable position, obesity and lack of exercise. bending or body position during static work.

Cuff width does not affect discomfort ratings immediately following isometric handgrip exercise

AbstractPrevious work has found that wide cuffs produce greater discomfort with elbow flexion exercise than narrower cuffs. It is our hypothesis that this is due to the balling up of the biceps underneath the cuff that is more pronounced with a wider cuff. One method to test this is through an upper body exercise where there is no contraction of the biceps.PurposeTo investigate the effects of cuff width on discomfort following isometric handgrip exercise.MethodsOne hundred participants completed this experiment. In a randomized order, the participants performed four sets of two-minute isometric handgrip contractions with thirty seconds of rest at thirty percent of their maximal voluntary contraction with a 5 and 12 cm cuff inflated to 40% of arterial occlusion pressure. Discomfort ratings (0–100) were given after the fourth set of exercise. Average force was recorded for all four sets.ResultsThere was no difference in discomfort (BF10 = 0.158) [median difference (95% credible interval) −0.997 (−3.360, 1.283) arbitrary units], or in average force (BF10 = 0.132) [median difference (95% credible interval) 0.08 (−0.199, 0.372) kilograms], between cuff conditions. There did not appear to be a greater preference for either cuff. Forty people preferred the narrow cuff (BF10 = 0.325), forty people preferred the wide cuff (BF10 = 0.325), and twenty people had no preference (BF10 = 7.719).ConclusionCuff width does not appear to influence discomfort or the average force produced. This provides support for our hypothesis that the shape of the muscle may interact with wider cuff sizes, leading to greater discomfort.

Acute effects of low-intensity isometric exercise at long and short muscle-tendon unit lengths.

Low-intensity training at long muscle-tendon unit lengths with a greater passive force may cause muscle swelling, which may be related to hypertrophy, even if the active force production is lower than that at short muscle-tendon unit lengths. This study compared muscle swelling after low-intensity torque-matched isometric exercises at long and short muscle-tendon unit lengths. Twenty-six volunteers performed isometric knee flexion exercises (30% of maximal voluntary contraction × 5 seconds × 10 repetitions × 9 sets) either at long or short lengths of the hamstrings (90° hip flexion and 30° knee flexion, or 90° hip and knee flexion, respectively). Active torque was calculated by subtracting passive torque from the total torque generated during exercise. Swelling-induced changes in cross-sectional area was assessed before and after exercise using ultrasonography. There was no between-group difference in the total torque during exercise; however, the active torque was significantly lower in the group trained at long than in the group trained at short muscle-tendon unit lengths. Muscle swelling occurred in both groups. The results suggest that exercise at long muscle-tendon unit lengths can cause similar muscle swelling as exercise at short muscle-tendon unit lengths, even in cases where active torque production is lower than that at short lengths.

Training in the Initial Range of Motion Promotes Greater Muscle Adaptations Than at Final in the Arm Curl.

The effects of ROM manipulation on muscle strength and hypertrophy response remain understudied in long-term interventions. Thus, we compared the changes in strength and regional muscle hypertrophy after training in protocols with different ranges of motion (ROM) in the seated dumbbell preacher curl exercise using a within-participant experimental design. Nineteen young women had one arm randomly assigned to train in the initial ROM (INITIALROM: 0°-68°; 0° = extended elbow) while the contralateral arm trained in the final ROM (FINALROM: 68°-135°), three times per week over an eight-week study period. Pre- and post-training assessments included one repetition maximum (1RM) testing in the full ROM (0°-135°), and measurement of biceps brachii cross-sectional area (CSA) at 50% and 70% of humerus length. Paired t-tests were used to compare regional CSA changes between groups, the sum of CSA changes at 50% and 70% (CSAsummed), and the strength response between the training protocols. The INITIALROM protocol displayed a greater CSA increase than FINALROM protocol at 70% of biceps length (p = 0.001). Alternatively, we observed similar increases between the protocols for CSA at 50% (p = 0.311) and for CSAsummed (p = 0.111). Moreover, the INITIALROM protocol displayed a greater 1RM increase than FINALROM (p < 0.001). We conclude that training in the initial angles of elbow flexion exercise promotes greater distal hypertrophy of the biceps brachii muscle in untrained young women. Moreover, the INITIALROM condition promotes a greater dynamic strength increase when tested at a full ROM compared to the FINALROM.

Exaggerated pressor responses, but unaltered blood flow regulation and functional sympatholysis during lower limb exercise in young, non-Hispanic black males.

Young non-Hispanic black (BL) males have displayed lower blood flow (BF) and vascular conductance (VC), but intact functional sympatholysis, during upper limb exercise when compared to non-Hispanic white (WH) males. This study sought to explore if similar differences were also present in the lower limbs. Thirteen young BL males and thirteen WH males completed one visit comprised of rhythmic lower limb (plantar flexion) exercise as well as upper limb (handgrip) exercise for a limb-specific comparison. Limb BF, mean arterial pressure (MAP), and VC were evaluated at three submaximal workloads (8, 16, and 24kg). To determine potential limb differences in functional sympatholysis, the impact of sympathetic nervous system activation (via cold-pressor test (CPT)) was evaluated at rest and during steady state exercise (30% of maximal voluntary contraction) on a subsequent visit. MAP responses to lower and upper limb exercise were elevated in young BL males (vs WH males), resulting in significantly lower VC responses in the upper limb, but not the lower limb. Further, BL males, when compared to WH males, revealed no differences in functional sympatholysis, evident by similar responses in both the exercising leg and arm VC during CPT. The findings of the current study indicate that although elevated MAP responses were observed during both lower and upper limb exercise in young BL males, vascular conductance was only hindered in the upper limbs. This may potentially highlight enhanced compensatory mechanisms in the lower limb (vs upper limb) to maintain perfusion in young BL males.

The reliability and validity of joint range of motion measurement using zoom and a smartphone application.

[Purpose] This study aimed to evaluate the reliability and validity of measuring the range of motion of joints using a remote videoconferencing system (Zoom) and a smartphone application. [Participants and Methods] This study included 16 young and healthy adults. The participants were instructed to perform shoulder joint flexion exercises in a seated position, with automatic motions, and maintain that posture throughout the measurement. Two measurements were performed: 1) angle measurement using a three-dimensional (3D) motion analyzer, and 2) angle measurement using the videoconference software, Zoom, and a smartphone application. Intra- and inter-rater reliabilities were calculated using the intraclass correlation coefficients (ICC). The degree of agreement between the representative values of each measurer and the 3D motion analyzer was examined. [Results] ICC (1, 1) for intra-examiner reliability were 0.912 and 0.996. For the inter-rater reliability, the ICC (2, 1) was 0.945. The correlation coefficient between each examiner's value and the value of the 3D motion analyzer was 0.955 and 0.980, respectively. The Bland-Altman analysis results indicated no systematic error. [Conclusion] The method of remotely measuring joint range of motion using Zoom and a smartphone application demonstrated high reliability and validity.

Comparison between the Effectiveness of McKenzie Extension Exercises and William Flexion Exercises for Treatment of Acute or Sub-acute Low Back Pain

Comparison between the Effectiveness of McKenzie Extension Exercises and William Flexion Exercises for Treatment of Acute or Sub-acute Low Back Pain

The role of individual physical body measurements and activity on spine kinematics during flexion, lateral bending and twist tasks in healthy young adults – Comparing marker(less) data

Understanding the relationship between physical characteristics and activity to kinematic properties of the spine has implications for sports, occupational tasks, clinical diagnosis and prognosis. This study aimed to categorize spine kinematics from flexion, lateral-bend, and twist exercises by examining the correlations to body-mass index (BMI), waist-to-hip ratio (WHR), and physical activity levels in healthy young adults. The data was collected from a marker-based optoelectronic motion capture setup and a marker-less motion capture with the RGB camera of a standard mobile phone. Comparing the accuracies of the two techniques on the same data set is important to develop inexpensive (RGB camera) diagnostics. Sixty-two participants (40 Male, 22 female) participated in the study. The angular displacement of the spine for each exercise was extracted by vector analysis using a single reference node/marker. The analysis showed no significant correlations of angular displacements values for the three movements with BMI or WHR. The physical activity level of male participants is significantly correlated with angular displacements for the flexion (p < 0.001) and lateral-bend (p-value ranges from 0.001 to 0.04) and weakly correlated (but not significant) for twist exercises. The physical activity level shows a significant correlation for only flexion (p < 0.001) in female participants. The findings emphasize the critical role of physical activity on musculoskeletal flexibility in young, healthy adults. The angles estimated using both techniques were comparable and significantly correlated across participants and exercises.

Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial

This 8-week randomized double-blind placebo-controlled study aimed to assess the effectiveness of supplementation with an extract of Cucumis sativus L. (20 mg/day) on pain and other variables in patients with knee osteoarthritis (OA) over 40 years. The change in pain intensity using a 1–10 cm visual analog scale (VAS) was the primary endpoint. Fifty-five patients (mean age 50.6 ± 8.6 years) were included (experimental group, n = 29; placebo, n = 26). VAS scores for pain decreased significantly in both study groups, but decreases were higher in the experimental group (between-group p = 0.013). Improvements in pain, stiffness, and physical function according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were also significantly higher in the experimental group. The Timed Up and Go test result also decreased significantly in the experimental group. An improvement in muscle function was associated with significant increases in isokinetic and isometric dynamometry variables, particularly for isometric 60°·s−1 and 180°·s−1 knee flexion exercises in the experimental group. Plasma levels of interleukin-1-beta (IL-1β) and matrix metalloproteinase-3 (MMP-3) also decreased significantly in the experimental group. Based on the beneficial effects of cucumber on symptomatology and inflammatory and cartilage degradation biomarkers in knee OA, cucumber extract supplementation may a useful natural approach to maintain healthy joints.

THE EFFECT OF WILLIAM FLEXION EXERCISE (WFE) ON LOW BACK PAIN AMONG NURSING IN DR. M. YUNUS HOSPITAL, BENGKULU CITY

Lower Back Pain (LBP) is pain that is felt in the lower back area. Based on the 2020 International Association for the Study of Pain, it shows that the results of the prevalence of LBP are estimated at ± 7.5% of the global population or around 577 million people who experience LBP. In Indonesia, data on the number of LBP sufferers themselves is not known with certainty, but it is estimated that the numbers vary from 7.6% to 37% of the total population in Indonesia. The prevalence of musculoskeletal diseases in Indonesia is 7.9% and there are three provinces with the highest prevalence, namely Aceh (13.3%), Bengkulu (10.5%) and Bali (8.5%). The purpose of this study was to determine whether there was an effect of William Flexion Exercise (WFE) on lower back pain for nurses at RSUD Dr.M. Yunus Bengkulu City. This type of research is quasi-experimental with a pre-post test design with control group, the sample is inpatient nurses in Seruni and Melati rooms at RSUD Dr. M. Yunus City of Bengkulu, totaling 28 people using Purposive Sampling technique. The results showed that the average value of low back pain before being given intervention in the intervention group was 6.00 while the average value of low back pain before being given intervention in the control group was 5.00. There is a difference in the average value of low back pain in the intervention group 1.00 and the control group 2.00. It can be concluded that William's flexion exercise is more influential than McKenzie's extension exercise.&#x0D; &#x0D;

Effects of Press Needle Intervention on Knee Flexion and Extension Movements: A Randomized Trial

Objective: Knee flexion exercise is a type of exercise therapy for improving knee-joint muscle strength. Among the knee extensors, the vastus medialis muscle is less active and prone to disuse atrophy. The effects of press needle acupuncture include vasodilation, which may affect blood flow in the vastus medialis. This study examined the effects of exercise stimulation + press needle stimulation on muscle blood flow. Materials and Methods: Conducted in Teikyo Heisei University, Tokyo, Japan, this randomized controlled trial involved 30 healthy adults in 3 groups (10 who did not receive stimulation, 10 who received exercise stimulation only, and 10 who received press needle stimulation + exercise stimulation). The stimulations were applied once per week, for 3 weeks. After resting for 10 minutes, the nonstimulated group rested for 2 additional minutes, and the other 2 groups performed knee flexion and extension exercises considered to be “very very hard on the Borg rating.” After this activity, the 2 stimulation groups rested for 10 minutes. Press needle stimulation was applied on the vastus medialis muscles of both thighs in the combination stimulation group. Results: The combination group had a smaller decrease in muscle tissue oxygen saturation and an increase in total hemoglobin, compared to the exercise only stimulation group. Conclusions: Press needle stimulation during exercise may dilate muscle blood vessels. Future studies should examine the effectiveness of this stimulation for age-specific and knee diseases.

Muscle sodium content in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

BackgroundMuscle fatigue and pain are key symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Although the pathophysiology is not yet fully understood, there is ample evidence for hypoperfusion which may result in electrolyte imbalance and sodium overload in muscles. Therefore, the aim of this study was to assess levels of sodium content in muscles of patients with ME/CFS and to compare these to healthy controls.MethodsSix female patients with ME/CFS and six age, BMI and sex matched controls underwent 23Na-MRI of the left lower leg using a clinical 3T MR scanner before and after 3 min of plantar flexion exercise. Sodium reference phantoms with solutions of 10, 20, 30 and 40 mmol/L NaCl were used for quantification. Muscle sodium content over 40 min was measured using a dedicated plugin in the open-source DICOM viewer Horos. Handgrip strength was measured and correlated with sodium content.ResultsBaseline tissue sodium content was higher in all 5 lower leg muscle compartments in ME/CFS compared to controls. Within the anterior extensor muscle compartment, the highest difference in baseline muscle sodium content between ME/CFS and controls was found (mean ± SD; 12.20 ± 1.66 mM in ME/CFS versus 9.38 ± 0.71 mM in controls, p = 0.0034). Directly after exercise, tissue sodium content increased in gastrocnemius and triceps surae muscles with + 30% in ME/CFS (p = 0.0005) and + 24% in controls (p = 0.0007) in the medial gastrocnemius muscle but not in the extensor muscles which were not exercised. Compared to baseline, the increase of sodium content in medial gastrocnemius muscle was stronger in ME/CFS than in controls with + 30% versus + 17% to baseline at 12 min (p = 0.0326) and + 29% versus + 16% to baseline at 15 min (p = 0.0265). Patients had reduced average handgrip strength which was associated with increased average muscle tissue sodium content (p = 0.0319, R2 = 0.3832).ConclusionMuscle sodium content before and after exercise was higher in ME/CFS than in healthy controls. Furthermore, our findings indicate an inverse correlation between muscle sodium content and handgrip strength. These findings provide evidence that sodium overload may play a role in the pathophysiology of ME/CFS and may allow for potential therapeutic targeting.

E-Book Physiotherapy Exercise Methods for Myogenic Low Back Pain

Myogenic low back pain is pain related to stress or strain on the back muscles, tendons and ligaments which are usually present when you do excessive daily activities. Low back pain needs to get attention because it can become a problem such as lost work time, reducing work productivity. Prevention of myogenic low back pain can be in the form of health education to batik artisans using exercise control sheet media. This research is a quasi-experimental study with a one group pre-test post-test design. The sample in this study amounted to 30 people. The sampling technique is by means of proportional stratified random sampling. The results showed that after doing the static stretching exercise, William Flexion Exercise, core stability using a control sheet had not made positive changes for batik craftsmen who experienced myogenic lower back pain.

Repeatability assessment for simultaneous measurement of arterial blood flow, venous oxygen saturation, and muscle perfusion following dynamic exercise.

The purpose of the present study was to demonstrate a new sequence and determine the repeatability of simultaneous dynamic measurements of blood flow, venous oxygen saturation (SvO2 ), and relative perfusion (change from resting perfusion) in calf muscle during recovery from plantar flexion exercise. The feasibility of near simultaneous measurement of bio-energetic parameters was also demonstrated. A sequence was developed to simultaneously measure arterial blood flow using flow-encoded projection, SvO2 using susceptibility-based oximetry, and relative perfusion using arterial spin labeling in combination with dynamic plantar flexion exercise. The parameters were determined at rest and during recovery from single leg plantar flexion exercise. Test-retest repeatability was analyzed using Bland-Altman analysis and intraclass correlation coefficients (ICC). The mitochondrial capacity of skeletal muscle was also measured immediately afterwards with dynamic phosphorus magnetic resonance spectroscopy. Eight healthy subjects participated in the study for test-retest repeatability. Popliteal artery blood flow at rest was 1.79 ± 0.58 ml/s and increased to 11.18 ± 3.02 ml/s immediately after exercise. Popliteal vein SvO2 decreased to 45.93% ± 6.5% from a resting value of 70.46% ± 4.76% following exercise. Relative perfusion (change from rest value) was 51.83 ± 15.00 ml/100 g/min at the cessation of exercise. The recovery of blood flow and SvO2 was modeled as a single exponential with time constants of 38.03 ± 6.91 and 71.19 ± 14.53 s, respectively. All the measured parameters exhibited good repeatability with ICC ranging from 0.8 to 0.95. Bioenergetics measurements were within normal range, demonstrating the feasibility of near simultaneous measurement of hemodynamic and energetic parameters. Clinical feasibility was assessed with Barth syndrome patients, demonstrating reduced oxygen extraction from the blood and reduced mitochondrial oxidative capacity compared with healthy controls. The proposed protocol allows rapid imaging of multiple parameters in skeletal muscle that might be affected in disease.

The impact of blood flow restricted electrical stimulations on recovery from muscle damage.

Both electrical stimulations (E-STIM) and blood flow restriction (BFR) have been shown to treat symptoms of exercise-induced muscle damage, but little is known about their combined effects which was the purpose of this study. Individuals completed one set of eccentric elbow flexion exercises to induce muscle damage. Forty-eight hours later, E-STIM was applied using an interferential current administered to both arms for 20 min; however, only one arm completed the E-STIM protocol while also undergoing repeated bouts of BFR (full occlusion for 2 min separated by a 1-min rest intervals). Discomfort and isometric strength were assessed immediately before the damaging exercise, immediately before the treatments, and 0, 10, and 30 min posttreatment. A total of 22 individuals (11 females) completed the study. There were no interactions with respect to discomfort (BF10 = 0.008) or isometric strength (BF10 = 0.009) indicating that the addition of BFR did not alter the effectiveness of E-STIM. There was a main effect of time indicating that the damaging exercise was successful at depressing torque (pre: 284 N, post: 199 N; BF10 = 2.70e9) and inducing discomfort (pre: 0 au, post: 6.4 au; BF10 = 3.21e17). While isometric strength did not recover with the E-STIM treatments, discomfort was reduced at each the immediate post (5.3 au; BF10 = 56 294) 10-min post (5.0 au; BF10 = 46 163), and 30-min post (4.9 au; BF10 = 707 600) time points. E-STIM may be useful for treating discomfort, but does not appear capable of recovering strength associated with muscle damage. The efficacy of E-STIM would not appear to be enhanced if performed under BFR.

THE EFFECT OF WILLIAM'S FLEXION EXERCISE ON THE LEVEL OF BACK PAIN DOWNTOWN ELDERLY IN THE TRESNA SOCIAL INTEGRATED SERVICE UNIT WERDHA BLITAR IN TULUNGAGUNG DISTRICT

Old age is a factor that aggravates the occurrence of lower back pain due to the decline in body functions, especially bone. William's flexion exercise is one of the therapeutic exercises for lower back pain sufferers by strengthening the abdominal muscles and maximus gluteus muscles and stretching the extensor muscles of the back. This study aimed to know the effect of William flexion training on lower back pain levels in older people in the Blitar Age Blind Social Service Unit at Tulungagung Dormitory. This research uses the Pre Experimental Design model one group pre-test - post-test design. The population of this study were all elderly at UPT Social Service of Tresna Werdha Blitar Tulungagung Dormitory who experienced low back pain; the sample was taken with a total sampling technique of 33 respondents. The variable of therapy-free William flexion is the dependent variable of lower back pain. The study was conducted on March 30-April 1, 2018, with data processing using the Wilcoxon signed rank test with the SPSS program. The result of the research was obtained before the therapy of William's flexion. Most respondents had severe back pain, 19 respondents (57.6%), and after the therapy of William's flexion, almost all respondents had mild back pain, as many as 27 respondents (81.8%). The result of the statistical test of Wilcoxon signed rank by using the SPSS program got the result P Value = 0.000 &lt;0.05, so H1 is accepted, which means there is the influence of William flex exercise to lower back pain level at elderly in the Technical Service Unit of Tresna Werdha Blitar at Tulungagung year 2018. William's flexion exercises will increase muscle elasticity, reduce pain, and restore work to some muscle groups. William's flexion movement is done slowly and rhythmically to stimulate the sensory nerve fibers that will inhibit the activation of pain receptors in Tresna Werdha Blitar Tulungagung Hostel.&#x0D;

Sex differences in blood pressure and inactive limb blood flow responses during dynamic leg exercise with increased inspiratory muscle work.

We hypothesized that, compared with young males, young females have a smaller decrease in blood flow to the inactive limb, accompanied by a smaller increase in arterial blood pressure, during dynamic exercise with increased inspiratory muscle work. Young males and females performed dynamic knee-extension and -flexion exercises for 10 min (spontaneous breathing for 5 min and voluntary hyperpnoea with or without inspiratory resistance for 5 min). Mean arterial blood pressure (MAP) and mean blood flow (MBF) in the brachial artery were continuously measured by means of finger photoplethysmography and Doppler ultrasound, respectively. No sex differences were found in the ΔMAP and ΔMBF (Δ: from baseline) during exercise without inspiratory resistance. In contrast, the ΔMAP during exercise with inspiratory resistive breathing was greater (P < 0.05) in males (+31.3 ± 2.1 mmHg, mean ± SE) than females (+18.9 ± 3.2 mmHg). The MBF during exercise with inspiratory resistance did not change in males (-4.4 ± 10.6 mL/min), whereas it significantly increased in females (+25.2 ± 15.4 mL/min). These results suggest that an attenuated inspiratory muscle-induced metaboreflex in young females affects blood flow distribution during submaximal dynamic leg exercise.

Impact of an isometric or eccentric hip extension exercise intervention on hamstring strength, architecture, and morphology: a randomised intervention trial

Introduction: Hamstring strain injury (HSI) is the leading cause of time lost from competition in running-based sports. Following return to sport, individuals with previous HSI often have persistent deficits in hamstring muscle strength, architecture and morphology. Considerable research effort has gone into identifying ways to address these variables, as they have been associated with future HSI risk. Eccentric knee flexion exercises have been shown to modify these variables, although implementation of these interventions in injury prevention programs is not widespread.

A MINI-REVIEW OF KINETIC STUDY ON SHOULDER JOINT USING KUKA LIGHTWEIGHT ROBOT

A Traditional physiotherapy sessions are long and demanding, requiring a lot of effort and time from both the physiotherapist and the patient. The KUKA LWR's high work capacity and consistent precision of end- effector location and movement were utilized to solve these issues. The KUKA LWR is a seven-degrees-of- freedom robotic manipulator designed for applications in which the robot must be near the human operator. During shoulder flexion exercises, which are commonly employed in traditional physiotherapy sessions, the robotic system pretends to analyze upper-limb behaviour, specifically the shoulder complex.

A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure.

Amiloride has been shown to inhibit acid-sensing ion channels (ASICs), which contribute to ischemia-related muscle pain during exercise. The purpose of this study was to determine if a single oral dose of amiloride would improve exercise tolerance and attenuate blood pressure during blood-flow-restricted (BFR) exercise in healthy adults. Ten subjects (4 females) performed isometric plantar flexion exercise with BFR (30% maximal voluntary contraction) after ingesting either a 10-mg dose of amiloride or a volume-matched placebo (random order). Time to failure, time-tension index (TTI), and perceived pain (visual analog scale) were compared between the amiloride and placebo trials. Mean blood pressure, heart rate, blood pressure index (BPI), and BPI normalized to TTI (BPInorm) were also compared between trials using both time-matched (TM50 and TM100) and effort-matched (T50 and T100) comparisons. Time to failure (+69.4 ± 63.2 s, P < 0.01) and TTI (+1,441 ± 633 kg·s, P = 0.02) were both significantly increased in the amiloride trial compared with placebo, despite no increase in pain (+0.4 ± 1.7 cm, P = 0.46). In contrast, amiloride had no significant influence on the mean blood pressure or heart rate responses, nor were there any significant differences in BPI or BPInorm between trials when matched for time (all P ≥ 0.13). When matched for effort, BPI was significantly greater in the amiloride trial (+5,300 ± 1,798 mmHg·s, P = 0.01), likely owing to an increase in total exercise duration. In conclusion, a 10-mg oral dose of amiloride appears to significantly improve the tolerance to BFR exercise in healthy adults without influencing blood pressure responses.