ABSTRACT In this paper, a design for a wearable solar energy harvesting system with an embroidered electrical circuit is proposed. The hybrid simulation method is carried out by using MATLAB/Simulink and LTSpice simulation software’s to extract the unknown electrical parameters of the multi-junction solar cell. A DC-DC boost converter (LTC3105) with MPPC is experimented to step up the solar cell voltage to 5 V. The solar energy harvester model achieves optimum simulated results in the LTSpice software with MPPT for both sunny and artificial shading conditions. The maximum conversion efficiency of the solar energy harvesting system with MPPC is 73.46 with an output voltage of 5 V and 68.29 at 4.10 V output voltage for flat and bent conditions, respectively. The fabricated system is tested in various conditions such as flat, bent condition with radius of 5.5 cm and artificial shading. The fabricated flexible solar cell power source can easily supply the power to wearable electronic, wireless sensors, and biomedical sensors. The solar cell and boost converter are integrated with jeans textiles to make whole system as wearable one and electrical connections are embroidered with conductive yarn. The fabricated wearable solar cell power source can easily supply the power to wearable biomedical sensors.