Flexible Scheduling Research Articles

Reducing treatment delays of first episode psychosis through policy in Canada: a mixed methods analysis of service provider perspectives

IntroductionYoung people with a first episode of psychosis can achieve full remission with prompt treatment. Throughout Canada, early psychosis intervention programs are implementing policies to ensure timely delivery of services. One of Canada’s first early intervention services, the Prevention and Early Intervention for Psychosis program, set the guideline that all youth referred should receive an appointment within 72 hours. The availability of early intervention programs has increased significantly but the standards these programs have adopted to ensure timely delivery of services remains unknown.ObjectivesThis project aims to identify the policies and practices in early intervention programs that ensure timely delivery of services. Secondly, the project aims to understand the level of awareness of the 72-hour recommendation and the level of adoption of this recommendation. Thirdly, the project aims to identify the factors that facilitate and hinder a program’s ability to reach and maintain their benchmarks for timely delivery of services.MethodsParticipants included 17 service delivery providers from four early intervention programs located in socio-culturally distinct regions in Canada. Participants completed a survey about their program’s service delivery policies and practices. We led individual semi-structured interviews with seven service providers to identify the barriers and facilitators to delivering timely care. We conducted frequency analyses of the survey data and thematic analysis of the interviews to identify emerging themes.ResultsForty-one percent of survey respondents indicated that their program implemented formal policies to minimize the delay to the first appointment, with benchmarks ranging from 72 hours to 12 weeks. The majority of program managers interviewed were aware of the 72-hour benchmark, voiced satisfaction with standards, and felt that establishing standards was helpful to delivering quality services. Average time between referral and first appointment ranged from 10 days to 12 weeks; however, more than half of survey respondents were unaware of the average delay in their program. Notable barriers to implementation included patient non-responsiveness, insufficient staffing, and missing patient contact information from referrals. The service providers reported engaged staff, flexible schedules, and team-based care as facilitators to meeting service delivery benchmarks.ConclusionsBenchmarks such as the 72-hour recommendation are an excellent step in improving timeliness of delivery of early intervention services. Common barriers to meeting benchmarks, such as patient adherence and staff resources may be difficult to overcome; however, implementing standardized referral forms and processes, increasing staff engagement, providing flexible schedules, and encouraging team-based care could improve timely delivery of services.Disclosure of InterestNone Declared

Гнучкий робочий графік на підприємстві: законодавче регулювання та особливості впровадження в HR-практику

Гнучкий робочий графік на підприємстві: законодавче регулювання та особливості впровадження в HR-практику

Factors influencing employee retention of academic home tutors in a private school

This study’s goal is to investigate the links between pay and benefits, worklife balance, professional development, and employee retention among academic home tutors in a Malaysian private school. Data from 80 respondents from this private school were gathered using a quantitative survey method. Statistical package for social science (SPSS) was employed throughout the study to analyze the data. The study results showed that salary & compensation and career enhancement positively correlate with employee retention. Meanwhile, work-life balance was not statistically linked with employee retention. The management should revise the human resource management practices by including these elements. The management should design salary & compensation packages that fit with individual knowledge, capabilities, and performance. The management may also consider offering flexible work schedules, such as training, mentoring, job mobility, and a reduction in working hours, as well as wellness assistance, such as counselling services and health and wellness initiatives. This will give employees the chance to advance their careers.

Work performance and quality of home and family life of solo family providers in HEIs

Managing work and personal life is a complex task. It involves figuring out how to separate and balance one's work life from personal life. This study looked into how satisfied solo family providers working in higher education institutions (HEIs) in a province in the Philippines were with their job performance and their family life at home. The study focused on 63 solo family providers who were carefully chosen for their crucial roles in four HEIs. The findings showed that these individuals were very pleased with both their job performance and their family life. Additionally, there was a strong and positive link between how happy they were with their jobs and how happy they were with their family life at home. Achieving a balance between work and personal life helps them to do well in their jobs and have satisfying and peaceful personal lives, which is good for both them and their families. Therefore, HEIs should create and offer specific programs to help solo family providers balance their work and personal lives better. These programs could include options for flexible work schedules, the ability to work from home, and access to counseling services.

Analysis of PPL Implementation in The Prajabatan PPG Program In The Field of Sociology Studies At SMA Negeri 1 Pontianak

This research aims to identify the effectiveness of implementing Field Experience Practices (PPL) in developing the competency of Pre-Service Teacher Professional Education Program (PPG) students at SMA Negeri 1 Pontianak. The relevance of this research lies in its contribution to improving the quality of learning in schools and preparing Pre-Service PPG students to become competent teachers and ready to face the dynamics of the world of education. This research method uses a descriptive qualitative approach through data collection techniques through observation, interviews, and document analysis. The research population was PPL PPG students in the field of Sociology studies at SMA Negeri 1 Pontianak, the research informants were 3 students. Effective PPL allows students to develop analytical, reflective skills and teacher identity through field interaction, observation and reflection. Even though they face obstacles such as limited schedules, effective communication between students and the school can overcome them. PPL plays an important role in forming competent and professional teachers in the future. Thus, this research provides recommendations for increasing the effectiveness of PPL implementation, including by optimizing communication between students and school officials, arranging flexible schedules, and increasing the availability of facilities at schools. By overcoming these obstacles, it is hoped that the implementation of PPL can run more effectively and efficiently so that students can develop competence as prospective teachers who are ready to face the dynamics of the world of education.

The Impact of Flexible Work Arrangements on Job Satisfaction

Abstract: This study examines the effects of flexible work arrangements on employee satisfaction, looking closely at elements like work-life balance, productivity, and job satisfaction. Understanding how these arrangements affect personnel is crucial in a dynamic corporate environment marked by flexible schedules and remote options. Telecommuting, flextime, and job sharing are just a few examples of flexible work arrangements that give employees more control over their professional lives. Numerous studies have examined how they affect organizational performance, work-life balance, and job satisfaction. Our study carefully examines prior research in an effort to provide insight into the complex interactions between flexible work schedules and employee satisfaction. Our goal is to educate organizations and decision-makers on how to design workspaces that promote employee well-being and lead to increased productivity

Emotional labor, job stress, and burnout of private primary and secondary schools towards a healthy life balance

This study delved into the intricate connection between emotional labor, job stress, and burnout among 193 nurturing educators from private primary and secondary schools at Shaoguan Experimental School in Guangdong, China. Using a descriptive-correlation approach, it leaned on the wisdom encapsulated in tried-and-true text like the MBI-GS questionnaire revised by Li Chaoping (2002), the self-assessment tool for burnout by Christina Maslach, and the insights of Cem Şafak Cukur.In the labyrinth of high-pressure teaching, the educators at Shaoguan Experimental School face towering stress levels and tread the middling grounds of burnout. The profound findings unravel a consistent, positive connective thread between Job Stress, Emotional Labor, and Job Burnout — a connection that swings from moderate to strong ties. The varying strains of emotional labor strike noteworthy chords. Surface Acting shows a potential yet slightly significant regulating influence. Active Deep Acting wields a substantial mediating effect, while Passive Deep Acting merely whispers with an almost imperceptible impact.The researcher recommends programs such as Job Stress Education, Meditation Exercises, Dance Movement Therapy, Flexible Scheduling, and Contextualized Seminars and pieces of training in attaining a healthy life balance based on the study's findings. Schools should develop strategies to mitigate job stressors, cultivate supportive and collaborative work, establish initiatives to support teachers' emotional well-being, offer further training programs on emotional labor management, and advocate for a balanced approach to emotional labor. Conversely, teachers should commit to the programs and play proactive roles in improving them.

The Perspectives On Piano Teaching Strategies At Qingdao Art School in Shandong Province

Background and Aim: Qingdao Art School is implementing a holistic piano education approach, combining traditional and modern techniques to prepare students for the evolving musical world and develop diverse skills. Materials and Methods: This study aimed to survey teacher’s perspectives on piano teaching strategies at Qingdao Art School. This study used qualitative research methodology, including semi-structured interviews with piano teachers at Qingdao Art School, to understand their teaching methods. Key areas of focus included pedagogical approaches, experiences with different strategies, challenges faced, and perspectives on effectiveness. The interview guideline was used to gather in-depth insights, with eight questions posed to experts. Data was collected through semi-structured interviews, with essential analysis steps including thematic coding, theme grouping, direct interpretation, and data presentation. Results: The text provides a comprehensive guide to teaching music theory, focusing on various pedagogical approaches. It suggests blended learning, collaborative projects, improvisational techniques, diverse musical genres, and gamification for accessibility. Challenges in teaching include adaptive teaching strategies, personalized music selection, practice routines, classroom community building, and integrating new technologies. Methods are promoted through active learning, digital resources, and flexible scheduling. Technology integration is highlighted, with music software, virtual performances, and AR/VR tools. Professional development opportunities are discussed, and student engagement and motivation are discussed. Evaluation and feedback are also discussed, considering technical skills and musical expression. Conclusion: The text offers a comprehensive guide to teaching music theory, highlighting various pedagogical approaches and challenges, while promoting active learning, digital resources, and technology integration.

Flexible Scheduling, Perceived Organizational Support and Employees’ Organizational Commitment: Mediation of Job Satisfaction

Flexible Scheduling, Perceived Organizational Support and Employees’ Organizational Commitment: Mediation of Job Satisfaction

Behind the Scenes: Radiotherapy technical training through professionals' eyes

Training technical professionals for Radiotherapy is essential due to growing demand caused by early cancer diagnoses, global population aging, rising cancer rates, and evolving equipment and techniques. Our objective was to gather insights from graduates of various courses who are now working professionally, based on the principle that one way to assess educational training is by considering the attributes that trained and active professionals deem important in the improvement courses they have taken.A cross-sectional study (approved at the local Research Ethics Committee) was conducted, involving an online survey for the opinion of professionals already qualified as radiotherapy technicians or technologists and engaged in this work. The questionnaire consisted of 12 objective multiple-choice questions and four open-ended questions.Of the 59 received responses, 49 professionals completed some course. Thirty-one (64.6%) pursued improvement/enhancement, followed by specialization (15; 31.2%) and extension (two; 4.2%). Thirty-four (69.4%) respondents had not engaged in any practical activities during their training. As for course weaknesses, respondents cited: inflexible schedule (29; 59.2%), distance from residence (12; 24.5%), low hourly load (four; 8.2%), and other issues (four; 8.2%).The data underscores the need to adjust technical training in Radiotherapy, emphasizing the importance of a recognized professional team, practical learning, flexible schedules, and financial viability.The strategic perspective of radiotherapy technicians currently working in this job market, emphasized the need for an adjustment in the offering of courses. These insights provide more well-structured foundations for contemporary teaching and learning processes, considering current societal characteristics, technological advances, and future student demands.

Returning to Work Following Hematopoietic Cell Transplantation: The Survivor's Perspective

While curing a patient's underlying disease is the primary goal of physicians performing hematopoietic cell transplantation (HCT), the ultimate objective is to provide patients with optimal post-HCT quality of life. For many survivors, this includes returning to work (RTW). We conducted a survey of 1- to 5-yr post-HCT survivors at our center to evaluate their perspective on facilitators and barriers to RTW as well as to gauge interest in potentially useful RTW support interventions. Survivors aged 18 to 65 yrs (n = 994) were sent an annual survey that included 36 supplementary questions about post-HCT RTW. Survey questions were selected from published national cancer survivor surveys and then modified specifically for HCT survivors. Three hundred forty-four (35%) survivors with a mean age of 53 yrs completed the survey, of whom 272 (79%) had worked prior to their diagnosis. Of those 272 patients, 145 (53%) were working currently and another 22 (8%) had attempted to go back to work following HCT but were not presently working. We found that having had an allogeneic versus autologous HCT (P = .006) was associated with a decreased likelihood of currently working, whereas frequent employer communication (>once a month) (P = .070) and having a more supportive employer (P = .036) were associated with a greater chance of currently working. Of survivors currently working, 45% reported that they had made one or more changes to their work schedule (e.g., flexible schedule or part-time work) or environment (e.g., work from home) upon RTW. Ninety-five percent of responders reported that they could have benefited from RTW support provided by the transplant center, but only 13% indicated that they had received it. Education on RTW challenges, information on disability benefits, and access to physical therapy were among the most requested support interventions. To improve post-HCT quality of life for survivors open to assistance, providers should address work status and goals, recognize barriers to successful return, and offer RTW support including working directly with employers. Allogeneic HCT survivors are particularly vulnerable to failing attempts to RTW and should be the target of retention interventions. A previously published manuscript on RTW guidance for providers of stem cell transplant patients endorsed by the American Society of Transplant and Cellular Therapy is available in Open Access and can be used as a tool to counsel and support these patients.

EXPLORING THE EFFICACY OF PLAY-BASED APPROACHES FOR ENHANCING NUMERACY INSTRUCTION: A LITERATURE REVIEW

This literature review examines the implementation of play-based learning activities in kindergarten settings to foster literacy and mathematical development. Play-based learning is recognized as a dynamic and effective approach that promotes creativity, curiosity, problem-solving skills, and positive social interactions among children. However, educators often face challenges in implementing play-based activities, including time constraints, resource limitations, and assessment complexities. To address these challenges, various strategies and interventions are explored, such as professional development, collaborative planning, flexible scheduling, and differentiated instruction. Leveraging community resources, adapting assessment methods, and advocating for the value of play-based learning further support its implementation. Through ongoing reflection on practice, teachers can continuously improve and refine their approach to play-based learning. Ultimately, prioritizing play-based activities in kindergarten classrooms creates enriching learning environments that support children's holistic development and lay a strong foundation for future academic success. Continued research, collaboration, and advocacy are essential to ensure the continued integration of play-based learning in early childhood education curricula.

Telecommuting and Travel Behaviour: A Survey of White-Collar Employees in Adelaide, Australia

COVID-19 prompted a significant number of employees to shift to remote work for the first time, potentially reshaping future work patterns. This study examines the post-COVID impacts on telecommuting, commuting behaviour, travel activities, and lifestyles in the city of Adelaide, South Australia. A multivariate nominal logistic regression analysis of 305 post-restriction survey responses revealed that home distance from the CBD, industry, occupation, and income significantly influence post-COVID telecommuting trends. Individuals living over 20 kilometres from the CBD, those in professional or managerial roles, and higher-income earners (>125k) are more prone to regular telecommuting, highlighting the impact of commute lengths, job flexibility, and financial resources on the ability to work remotely. The study revealed a higher adoption of telecommuting post-COVID, with more individuals working from home and telecommuting more often each week. This led to reduced usage of private cars and public transport, indicating a decrease in overall travel frequency. Respondents also adopted flexible work schedules, resulting in fewer peak-hour commutes, which would have resulted in lower congestion and emissions and led to more sustainable travel practices. The study also investigated future telecommuting perspectives, revealing a preference for remote work 3–4 days a week. Some respondents who initially could not telecommute have since considered it feasible and want to adopt it. Notably, about 25% of respondents would even change jobs for flexible, home-based work arrangements. The study’s results suggest that remote work frequency may influence individuals’ future house location preferences. These findings offer valuable insights for sustainable transport and urban planning considerations in the post-COVID era.

A non-linear convex model based energy management strategy for dual-storage offshore wind system

—Using hydrogen production as energy storage can realize large-scale storage and transportation of energy, which is conducive to flexible scheduling of offshore wind power resources. However, compared with the battery energy storage system, the energy management strategy (EMS) of the dual-storage offshore wind power system with hydrogen production is more complex and nonlinear due to the large number of state variables and control variables. In order to realize the EMS of the system to maximize the benefits and minimize the aging cost, a nonlinear convex model is first established, and then an iterative solution method combining convex programming (CP) and dynamic programming (DP) is proposed. Among them, CP solves the global optimization problem of power distribution, and DP determines the start and stop of the electrolyzer. Finally, the feasibility of the proposed method is verified by simulation analysis.

Dermatology residents' perspectives on virtual dermatopathology education.

Dermatopathology education accounts for 30% of U.S. dermatology residency training. The COVID-19 pandemic expedited the implementation of virtual dermatopathology in place of traditional microscopy for resident education. This study examined U.S. dermatology residents' perceptions of virtual dermatopathology, as research in this area is lacking. An anonymous, confidential, institutional review board-approved survey was electronically distributed to U.S. dermatology residents consisting of 16 questions comparing attitudes towards virtual and traditional dermatopathology education. Responses were n = 59. Statistical analysis was performed using SAS software. Participants believe virtual imaging is superior to conventional microscopy in schedule flexibility (96.6% vs. 1.7%, p < 0.0001), lecture convenience (94.8% vs. 0.0%, p < 0.0001), personal review (96.6% vs. 0.0%, p < 0.0001), cost-effectiveness (64.4% vs. 6.8%, p < 0.0001), and board exam preparation (52.5% vs. 16.9%, p = 0.0005). Conventional microscopy was favored for image quality (50.8% vs. 25.4%, p = 0.0127) and overall utility (50.8% vs. 27.1%, p = 0.0195). Our study supports virtual dermatopathology utilization as a valuable tool in dermatology residency training. Also it is shown that conventional microscopy training continues to play a key role. Further studies should examine whether, if ever, virtual dermatopathology could gradually replace conventional microscopy with the advent of newer and more powerful digital and scanning technology.

Optimizing integrated lot sizing and production scheduling in flexible flow line systems with energy scheme: A two level approach based on reinforcement learning

Many production environments are faced with the need to simultaneously determine the planning of lot sizing and the scheduling of production sequences while ensuring cost minimization. This issue becomes even more complex when integrating multiple energy sources with the goal of a low-carbon economy. To address this challenge, this paper proposes an integrated lot sizing and flexible flow line production scheduling model under a time-of-use pricing scheme. In addition, the model takes into account conventional grid power, on-site renewable energy sources, and an energy storage system. The associated objective function is solved adopting a two-level approach to optimize energy costs while maintaining production throughput and meeting customer demand. The implementation relies on reinforcement learning capabilities to tackle complexity issues. The proposed approach is evaluated on a benchmark case and its results are compared with those obtained with First-In-First-Out heuristic, genetic algorithm and CPLEX. These results highlight the promising aspect of the proposed approach in terms of performance.

An improved memetic algorithm for multi-objective resource-constrained flexible job shop inverse scheduling problem: An application for machining workshop

Resource-constrained flexible job shop scheduling problems are commonly encountered in some manufacturing industries, and have been widely studied in recent years. However, traditional resource constrained flexible job shop scheduling problem rarely consider the uncertainties in actual manufacturing systems, which may make the original schedule become suboptimal or even unfeasible. Therefore, a resource constrained flexible job shop inverse scheduling problem (RCFJISP) is proposed in this paper, which aims to cope with uncertain events by simultaneously adjusting the machine, worker and process parameters of the original schedule. A multi-objective optimization model is constructed to minimize the makespan, worker cost, machine energy consumption and deviation index. Furthermore, an improved memetic algorithm (IMA) is developed for solving the proposed problem. In IMA, a novel double-layer encoding mechanism is designed to enhance the capacity in exploring new solution’s domains. Three initialization strategies utilizing original scheduling information are designed to improve the quality of initial solutions. An adaptive mutation strategy and a local search mechanism are designed to enhance exploration and exploitation ability of the algorithm. And a crowding operator is proposed to reflect the diversity of the population effectively. In computational experiments, 28 extended benchmarks are constructed, and the effectiveness of the proposed strategy and algorithm is verified by comparing IMA with its 4 variants and other 4 widely used algorithms. Finally, two inverse scheduling problems of a real-world hydraulic cylinder machining workshop under two uncertain situations are studied. The results demonstrate that IMA can effectively solve the actual inverse scheduling problem. With a slight adjustment to the original scheduling, it can reduce the makespan by 11.5%, the worker cost by 8.1% and the machine energy consumption by 27.9% on average.

TEARS OF HOPE: THE PLIGHT OF WORKING STUDENTS UNDER TVL-LATE AFTERNOON PROGRAM

This study investigated the challenges faced by working students enrolled in the Technical Vocational Livelihood Late-Afternoon Program (TVL-LAP) and examined the impact of their employment on their academic performance. The research design employed was descriptive-qualitative, using a phenomenological approach to capture the participants' authentic stories and experiences through in-depth interviews and focus group discussions. Thematic analysis using Creswell’s (2013) six steps in the qualitative data analysis process was applied to identify prominent patterns within the interviews, which were categorized according to the main themes and core ideas. After the data analysis, three (3) essential themes emerged across all the study questions. Essential themes in the experiences and challenges focused on providing for economic needs, meeting multiple demands, and seeking consideration. Self-motivation, finding time to study, and compassionate teachers and peers were revealed as essential themes in coping mechanisms. Commitment to goals in life, the value of support from God and others, and helping oneself surfaced in shared insights. Findings suggest that providing flexible schedules or alternative work arrangements, offering academic support services, encouraging peer support groups, and providing training and support in time management and problem-solving can help students become more resourceful and efficient in balancing academic and work responsibilities.&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt; Article visualizations:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;img src="/-counters-/soc/0758/a.php" alt="Hit counter" /&gt;&lt;/p&gt;

Exploring nurses' experiences: Abandoning the profession and migrating for improved opportunities

AimThis study explores nurses' experiences in migration for employment and professional abandonment in Barcelona (Spain). MethodsEmploying a mixed-design approach comprising 1) a qualitative descriptive phenomenological study, followed by 2) a subsequent cross-sectional study, 20 and 225 nurses participated in each study, respectively. Qualitative data, gathered through 4 focus group discussions, underwent inductive thematic analysis, following the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines, while quantitative data were descriptively analyzed. FindingsThree qualitative themes emerged: 1) Migration motives, such as improved job opportunities, permanent contracts, continuous training, and professional recognition; 2) Reasons for leaving or contemplating leaving the profession, including excessive workload, lack of recognition, limited development, and exhaustion; 3) Nurses' needs, encompassing more staffing, improved remuneration, permanent contracts, flexible schedules, greater autonomy, and career growth. The cross-sectional study revealed a 13.5 % professional abandonment rate at some point across all demographics and seniority levels. Migration trends varied by professional experience, with younger nurses seeking better conditions and opportunities elsewhere. ConclusionsMultifactorial causes underlie job migration and professional abandonment, necessitating comprehensive interventions to improve nurses' working and professional conditions.

Abstract 613: Oral CHK1 inhibitor BBI-355 allows flexibility of dose and schedule with demonstration of monotherapy and combinational antitumor activity in extrachromosomal DNA (ecDNA) driven preclinical models

Abstract Focal, high copy number amplifications of prevalent oncogenes (e.g., MYC, EGFR) frequently occur on extrachromosomal DNA (ecDNA), highly transcribed units of circular, non-chromosomal DNA. While use of targeted therapies is associated with improved survival in patients with cancers that have activating oncogene mutations or fusions, they have demonstrated limited activity for patients whose tumors harbor oncogene amplifications, including those mediated by ecDNA. We have previously identified Checkpoint Kinase 1 (CHK1) as a target essential for ecDNA function in cancer, as tumor cells with oncogene amplification on ecDNA exhibit increased DNA replication stress (RS) and are hypersensitive to inactivation of CHK1, cells’ master regulator of RS. Thus, we have developed BBI-355, a novel, orally bioavailable, and selective small molecule inhibitor of CHK1, which is currently being studied in the first-in-human Phase 1/2 POTENTIATE clinical trial for patients with cancer harboring oncogene amplifications, including on ecDNA (NCT05827614). In vitro antiproliferation activity of BBI-355 was observed in a panel of ecDNA+ oncogene amplified tumor lines and non-amplified lines, with heightened sensitivity and induction of RS observed in ecDNA+ cells. Oral administration of BBI-355 resulted in dose dependent on-target activity, with induced p-CHK1-S345 protein expression, in agreement with measured plasma and tumor concentrations. Subsequent pharmacokinetic/pharmacodynamic (PK/PD) modeling guided continuous and intermittent dose/schedules of single agent BBI-355 that demonstrated durable antitumor activity, including tumor regressions, in multiple ecDNA+ tumor models. Single agent targeted therapy treatment of cancers with oncogene amplification on ecDNA can result in acquired resistance via ecDNA-based mechanisms, further increasing reliance on CHK1. Enhanced antitumor activity of BBI-355 in combination with agents targeting the protein products of amplified oncogenes was demonstrated in multiple in vivo tumor models; these included combination with a pan-FGFR inhibitor in FGFR2 ecDNA+ amplified gastric cancer and combination with CDK4/6 inhibitors in CDK4 ecDNA+ amplified sarcoma models. The first ecDNA-directed therapy (ecDTx) in development, BBI-355 demonstrated significant antitumor activity as a single agent and in combination with targeted therapies in multiple ecDNA+ oncogene amplified tumor models. Oral dosing of BBI-355 provides dose/schedule flexibility to attempt to optimize antitumor activity with a tolerable safety profile in patients with highly aggressive cancers and significant unmet need. The POTENTIATE clinical trial is open and currently enrolling. Citation Format: Ryan J. Hansen, Auzon Steffy, Joshua Plum, Ardalan Ardeshiri, Edison Tse, Salvador Garcia, Ben Norman, Jafar Moininazeri, AnneMarie Pferdekamper, Evan Holmes, Debbie Liao, Rachelle Elsdon, Joshua Lange, Anthony Pinkerton, Julius Apuy, Sudhir Chowdhry, Christian Hassig, Shailaja Kasibhatla. Oral CHK1 inhibitor BBI-355 allows flexibility of dose and schedule with demonstration of monotherapy and combinational antitumor activity in extrachromosomal DNA (ecDNA) driven preclinical models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 613.