Flat Profile Research Articles

Coated boron layers by boronization and a real-time boron coating using an impurity powder dropper in the LHD

In the Large Helical Device (LHD), diborane (B2H6) is used as a standard boron source for boronization, which is assisted by helium glow discharges. In 2019, a new Impurity Powder Dropper (IPD) system was installed and is under evaluation as a real-time wall conditioning technique. In the LHD, which is a large-sized heliotron device, an additional helium (He) glow discharge cleaning (GDC) after boronization was operated for a reduction in hydrogen recycling from the coated boron layers. This operational time of 3 h was determined by spectroscopic data during glow discharges. A flat hydrogen profile is obtained on the top surface of the coated boron on the specimen exposed to boronization. The results suggest a reduction in hydrogen at the top surface by He-GDC. Trapped oxygen in coated boron was obtained by boronization, and the coated boron, which has boron-oxide, on the first wall by B-IPD was also shown. Considering the difference in coating areas between B2H6 boronization and B-IPD operation, it would be most effective to use the IPD and B2H6 boronization coating together for optimized wall conditioning.

Turbulence-reduced high-performance scenarios in Wendelstein 7-X

In the Wendelstein 7-X (W7-X) stellarator, turbulence is the dominant transport mechanism in most discharges. This leads to a ‘clamping’ of ion temperature over a wide range of heating power, predominantly flat density profiles where hollow profiles driven by neoclassical thermo-diffusion would be expected and by rapid impurity transport in injection experiments. Significantly reduced turbulent transport is observed in the presence of strong core density gradients found transiently after core pellet injection and irregularly after boronisation or boron pellet injection. Density peaking is also achieved in a controlled manner in purely neutral beam heated discharges where particle transport analysis reveals an abrupt reduction in the main-ion particle flux leading to significant density profile peaking not explained by the NBI particle source alone. The plasmas exhibit a heat diffusivity of around χ=0.25±0.1m2 s−1 at mid radius, a factor of around 4 lower than ECRH dominated discharges. Despite the improved confinement, the achieved ion temperature is limited by broader heat deposition and the lower power-per-particle given the higher density. This is overcome with limited reintroduction of ECRH power, where the low heat diffusivity diffusivity is maintained, the density rise supressed and ion temperatures above the clamping limit are achieved. The applicability of these plasmas for a high performance scenario on transport relevant time scales is assessed, including initial predictions for planned heating upgrades of W7-X, based on a range of assumptions about particle transport.

Stereophotometric facial changes in edentulous older adults after rehabilitation with complete dentures.

To evaluate the facial characteristics of edentulous older adults who underwent rehabilitation using complete dentures, and to compare them with dentate individuals. Edentulism rehabilitation with complete dentures aims to restore occlusion and facial aesthetics. The study included 102 edentulous participants needing prosthodontic rehabilitation with complete dentures and 30 with a natural dentition (aged >65). The 3D facial scans were performed using an Artec optical scanner. Superficial facial landmarks were identified, and 16 parameters were calculated. Regional analysis with the superimposition of two scans was used to calculate the average distances and percentage of non-matching surfaces in the 11 regions. Paired and independent t-tests (α = .05) were used to test for group differences, as appropriate. After rehabilitation with complete dentures, facial changes were most noticeable in the perioral region: wider rima oris, longer upper lip, wider upper vermilion, and more protruded profile. The comparison of facial regions without and with dentures showed fuller and curvier cheeks, with no direct influence of dentures. The edentulous faces with dentures appeared shorter and more retruded than those of dentate individuals. A narrower lower vermilion, retruded upper lip, and more flattened facial profile were observed in females with dentures than in their dentate peers. Besides the expected positive influence of rehabilitation with complete dentures on facial appearance in the perioral region, there are some unexpected changes, such as fuller cheeks, but there is still deficiency in vertical facial dimensions and a more flattened facial profile.

Hybrid LES/RANS Simulations of Compressible Flow in a Linear Cascade of Flat Blade Profiles

The paper reports on 3D numerical simulations of unsteady compressible airflow in a blade cascade consisting of flat profiles using a hybrid LES/RANS approach including a transition model. As a first step towards simulation of blade flutter in turbomachinery, various incidence angle offsets of the middle blade were modeled. All simulations were run for the flow regime characterized by outlet isentropic Mach number Mis=0.5 and zero incidence. The results of the LES/RANS simulations (pressure and Mach number distributions) were compared to a baseline RANS model, and to experimental data measured in a high-speed wind tunnel. The numerical results show that both methods overpredict flow separation taking place at the leading edge. In this regard, the hybrid LES/RANS method does not provide superior results compared to the traditional RANS simulations. Nevertheless, the LES/RANS results also capture vortex shedding from the blunt trailing edge. The frequency of the trailing edge vortex shedding in CFD simulations matches perfectly the spectral peak recorded during wind tunnel measurements.

The miniJPAS Survey: The radial distribution of star formation rates in faint X-ray active galactic nuclei

We study the impact of black hole nuclear activity on both the global and radial star formation rate (SFR) profiles in X-ray-selected active galactic nuclei (AGN) in the field of miniJPAS, the precursor of the much wider J-PAS project. Our sample includes 32 AGN with z < 0.3 detected via the XMM-Newton and Chandra surveys. For comparison, we assembled a control sample of 71 star-forming (SF) galaxies with similar magnitudes, sizes, and redshifts. To derive the global properties of both the AGN and the control SF sample, we used CIGALE to fit the spectral energy distributions derived from the 56 narrowband and 4 broadband filters from miniJPAS. We find that AGN tend to reside in more massive galaxies than their SF counterparts. After matching samples based on stellar mass and comparing their SFRs and specific SFRs (sSFRs), no significant differences appear. This suggests that the presence of AGN does not strongly influence overall star formation. However, when we used miniJPAS as an integral field unit (IFU) to dissect galaxies along their position angle, a different picture emerges. We find that AGN tend to be more centrally concentrated in mass with respect to SF galaxies. Moreover, we find a suppression of the sSFR up to 1Re and then an enhancement beyond 1Re, strongly contrasting with the decreasing radial profile of sSFRs in SF galaxies. This could point to an inside-out quenching of AGN host galaxies. Additionally, we examined how the radial profiles of the sSFRs in AGN and SF galaxies depend on galaxy morphology, by dividing our sample into disk-dominated (DD), pseudo-bulge (PB), and bulge-dominated (BD) systems. In DD systems, AGN exhibit a flat sSFR profile in the central regions and enhanced star formation beyond 1Re, contrasting with SF galaxies. In PB systems, SF galaxies show a decreasing sSFR profile, while AGN hosts exhibit an inside-out quenching scenario. In BD systems, both populations demonstrate consistent flat sSFR profiles. These findings suggest that the reason we do not see differences on a global scale is because star formation is suppressed in the central regions and enhanced in the outer regions of AGN host galaxies. While limited in terms of sample size, this work highlights the potential of the upcoming J-PAS as a wide-field low-resolution IFU for thousands of nearby galaxies and AGN.

Ferrofluid‐based electrical machines: Conceptualization and experimental evaluation

AbstractThis article intends to propose a new concept of electric machines that works based on a category of magnetic fluids called “ferrofluids”. For this purpose, a disc‐shaped rotor filled with ferrofluid material is employed instead of a common rotor of an axial‐flux machine, and the conceptual design of the new machine named here “axial‐flux ferrofluid electric machine (FFEM)” is presented. The operation principle of the FFEM is described and a dynamic‐transient model built on the d–q axes equivalent circuits is presented. Simulations are carried out by applying the given model in MATLAB and the results are investigated in different operating conditions. In order to identify the basic parameters and validate the simulation results, a prototype of the FFEM has been designed and manufactured, and some preliminary functional tests have been performed on the prototype. All simulation and experimental results indicate some distinguished excellent performances of the new machine. In the end, it can be stated briefly with some confidence that ferrofluid electric machines can have a high potential for future research and applications in various industries due to the simplicity of the structure, self‐starting capability, ability to work at a wide range of speeds and a flat torque profile.

Empirical Orthogonal Function Analysis on Long-Term Profile Evolution of Tidal Flats along a Curved Coast in the Qiantang River Estuary, China

Abstract: Tidal flats are dynamic coastal ecosystems continually reshaped by natural processes and human activities. This study investigates the application of Empirical Orthogonal Function (EOF) analysis to the long-term profile evolution of tidal flats along the Jiansan Bend of the Qiantang River Estuary, China. By applying EOF analysis to profiles observed from 1984 to 2023, this study identifies dominant modes of variability and their spatial and temporal characteristics, offering insights into the complex sediment transport and morphological evolution processes. EOF analysis helps unravel the complex interactions between natural and anthropogenic factors shaping tidal flats, with the first three eigenfunctions accounting for over 90% of the observed variance. The first spatial eigenfunction captures the primary trend, while the subsequent two eigenfunctions reveal secondary and tertiary modes of variability. A conceptual model developed in this study elucidates the interplay between hydrodynamic forces and morphological changes, highlighting the rotation and oscillation of tidal flat profiles in response to seasonal variations in hydrological conditions. The findings emphasize the effectiveness of EOF analysis in capturing significant geomorphological processes and underscore its potential in enhancing the understanding of tidal flat dynamics, thereby informing more effective management and conservation strategies for these critical coastal environments.

Frequency and Severity of Hypoglycemia Under Conditions of Increased Hypoglycemic Risk with Insulin Efsitora Alfa Versus Insulin Glargine Treatment in Participants with Type 2 Diabetes.

Insulin efsitora alfa (efsitora) is a basal insulin with a flat pharmacokinetic profile and long half-life, enabling weekly dosing. These attributes may provide stable glucose levels. This exploratory phase 1 study aimed to assess the hypoglycemic risk during experimental conditions that mimic situations encountered in daily life. This was a single-site, open-label, two-period, fixed-sequence study in participants with type 2 diabetes (T2D) previously treated with basal insulin. The incidence, duration, and nadir glucose of hypoglycemia were assessed after treatment with efsitora versus insulin glargine (glargine) during three provocation conditions: 24-h prolonged fasting, prolonged fasting with exercise, and double dosing of study insulin. The 54 enrolled adults (BMI 21.8-39.7kg/m2, HbA1c 6.5-9.4%) achieved stable fasting glucose before undergoing provocation. Most hypoglycemic events were level 1 (≥ 54 to < 70mg/dL) and resolved spontaneously or after oral glucose. The incidences of level 1 hypoglycemia for efsitora and glargine were not significantly different: for prolonged fasting, the incidences were 44.7 vs. 42.6% and the difference in proportion was 2.1% (95% CI: - 17.2, 21.4); for prolonged fasting with exercise, the corresponding values were 65.9 vs. 50.0% and 15.9% (- 3.0, 34.8); for double dosing, the corresponding values were 68.1 vs. 61.7% and 6.4% (- 12.8, 25.6). Level 2 hypoglycemia (< 54mg/dL) was infrequent during both treatments and all provocations. No severe hypoglycemia was observed. Mean nadir glucose (range 62.8-66.3mg/dL) and hypoglycemia duration (range 76.6-115.2min) were also similar for the two treatments, depending on the provocation. Overall, weekly efsitora did not increase the incidence, duration, or severity of hypoglycemia compared to daily glargine during provocation periods in patients with T2D. ClinicalTrials.gov identifier NCT04957914.

Design and analysis of the C6H6-filled circular photonic crystal fiber with ultra-flat dispersion for broadband supercontinuum generation with peak power of 130 W and 250 W

This article introduces a new model of a circular silica-based photonic crystal fiber with a hollow core filled with C6H6. The difference in the air hole size and the distance between them in the first ring around the core has a profound effect on the dispersion, leading to ultra-flat dispersion with values as low as ±0.996 ps nm−1· km in wavelength range 0.74 µm. The high nonlinear coefficient of several 1000 W−1 · km−1 and the low confinement loss of a few tens of dB m−1 suggest proposing three fibers with dispersion and nonlinear properties suitable for broadband supercontinuum generation at low peak power. The influence of peak power on the broadening of the supercontinuum spectrum is also investigated. Fibers with a flat all-normal dispersion profile provide a smooth spectrum with bandwidths of 1.215 and 1.626 µm at 30 dB with a peak power of 250 W. A fiber with an anomalous dispersion regime generates a supercontinuous spectrum, broadening to 3.868 µm in the mid-infrared region (2.467 µm bandwidth at 30 dB) under laser pulse excitation with 130 W peak power. Our results provide further insights into the generation of broadband mid-infrared supercontinuum using liquid-core silica-fibers, which have great potential for applications in the fields of optical communications and optical sensing.

Core density profile control by energetic ion anisotropy in LHD

Electron and impurity ion density profiles have been controlled by using tangential and perpendicular neutral beams for plasma heating in a stellarator/heliotron for the first time. Reduced anisotropy of stored energy for energetic ion En⊥/Enǁ has resulted in an inward electron and impurity transport, forming a core electron density peaking. Increased anisotropy leads to a flat or hollowed electron density profile with an impurity exhaust in a core region [Yoshinuma et al., Nucl. Fusion 49, 062002 (2009)]. A high confinement state of particles in LHD has yet to be achieved, except for a temporal state of an electron density peaking created by a pellet injection. As a pioneering and crucial research result, the operation of energetic ion anisotropy by neutral beams has newly demonstrated that the direction of the radial transport of bulk and impurity ions can be controlled. At the same time, the overall plasma performance rises in neutron flux and stored energy. On the other hand, the increase in the anisotropy flattens the density profile. This new finding holds promise for a control knob of nuclear fusion reactors to enhance fusion power output.

RF linearity and improved transconductance of ScAlN/GaN HEMT with novel inverse L-shaped gate structure

In this study, we investigate the enhancement of effective transconductance and gain linearity in submicrometer gate AlGaN-barrier-based transistors utilizing ScAlN/GaN coupling-channel structures. A novel asymmetric gate design, incorporating an AlGaN cap on ScAlN/GaN HEMT, is proposed. This configuration demonstrates a flat transconductance profile and significantly reduced transconductance derivative, thereby improving the linearity of GaN-based transistors. For transistors with a gate length of 0.5 μm, both the current gain cut-off frequency and power gain cut-off frequency are measured at 53.52 GHz and 72.98 GHz, respectively. These values represent a more than threefold increase from the corresponding frequencies of conventional devices. Moreover, the theoretical Output Third-Order Intercept value of the proposed structure has increased by 7.5 dBm compared to conventional HEMTs. This superior linear performance can be attributed to the combined effect of AlGaN cap layer and air cavity. Furthermore, the introduction of the ScAlN layer results in a substantial impact, including a decrease in electron concentration from 4.96 × 1019/cm3 to 1.98 × 1019/cm3 and an increase in electron velocity from 4.5 × 107 to 7.6 × 108 cm/s. These findings underscore the potential of the proposed device for high-frequency applications requiring superior linearity.

Characterising galaxy clusters’ completeness function in Planck with hydrodynamical simulations

Galaxy cluster number counts are an important probe with which to constrain cosmological parameters. One of the main ingredients of the analysis, along with accurate estimates of cluster masses, is the selection function, and in particular the completeness associated with the cluster sample under consideration. Incorrectly characterising this function can lead to biases in cosmological constraints. In this work, we want to study the completeness of the Planck cluster catalogue, estimating the probability of cluster detection in a realistic setting using hydrodynamical simulations. In particular, we probe the case in which the cluster model assumed in the detection method differs from the shapes and profiles of true galaxy clusters. We created around 9000 images of the Sunyaev–Zel’dovich effect from galaxy clusters from the IllustrisTNG simulation, and used a Monte Carlo injection method to estimate the completeness function. We studied the impact of having different cluster pressure profiles and complex cluster morphologies on the detection process. We find that the cluster profile has a significant effect on completeness, with clusters with steeper profiles producing a higher completeness than ones with flatter profiles. We also show that cluster morphology has a small impact on completeness, finding that elliptical clusters have a slightly lower probability of detection with respect to spherically symmetric ones. Finally, we investigate the impact of a different completeness function on a cosmological analysis with cluster number counts, showing a shift in the constraints on Ωm and σ8 that lies in the same direction as the shift driven by the mass bias.

The role of sawtooth-shaped nano riblets on nanobubble dynamics and collapse-induced erosion near solid boundary

In this research, surfaces inspired by shark skin were engineered for aluminum (Al) slabs to investigate the influences of riblets on the collapse dynamics of nanobubbles and the resultant erosion on the slab surfaces. These effects were probed through molecular dynamics simulations. Specifically, surfaces with flat profiles as well as those with small and high sawtooth-shaped nano riblets were modelled for analysis. Near the flat surface, due to the absence of riblets, the water nanohammer, with its semi-spherical shape containing water beads under approximately 30 GPa pressure and 5000 K temperature, impulse the Al slab, transferring both temperature and pressure, thereby inducing maximum erosion. Conversely, surfaces containing riblets separate some parts of water vortices, leading to a shorter collapse time of the nanobubble and the creation of a water nanohammer with a smaller volume compared to their values near a flat surface. Moreover, due to the initial impulse of the water nanohammer to the peak of the riblet, the nanohammer splits into two or three inclined shapes. Then, they diagonally impact the main part of the Al slab, resulting in erosion. The decentralization and diagonal impulse of the water nanohammer in the presence of riblets create a lower erosion volume and depth compared to these values on a flat surface. In summary, it can be inferred that riblets can serve as a passive control method for managing erosion, thereby increasing the lifetime of hulls for ships or submarines.

Multi-method examination of contact mechanics in orthotropic layers under gravity

Analyzing the behavior of intelligent unconventional materials under diverse contact scenarios, in comparison to conventional materials, is a critical step in the initial design of engineering systems. This paper presents the development of analytical and numerical approaches for analyzing contact mechanics in a system comprising an orthotropic layer resting on a rigid foundation. Parametric analyses include the consideration of cylindrical and flat punch profiles. Analytical formulation utilizes integral transform methods to convert planar elasticity equations into a Cauchy-type singular integral equation of the second kind. A detailed description of the solution technique for the integral equation is provided, encompassing both the analytical formulation and the required discretization for obtaining the solution. Subsequently, a finite element approach (FEA) is employed to approximate contact bodies using a collection of finite elements, while contact boundaries are approximated by utilizing a set of polygons. Alternatively, the problem is addressed using the Multilayer Perceptron approach, a form of artificial neural network frequently applied in diverse machine learning applications, including scenarios involving contact problems. Finally, the resolution to the problem is achieved by employing the multilayer perceptron (MLP) method. The study yields determinations of contact stresses under the punch, the critical separation load resulting in the detachment of the orthotropic layer from the rigid foundation, and the corresponding separation distance. This analysis considers a range of dimensionless parameters and explored the behavior of diverse orthotropic materials. Comparisons between the results of the analytical method and computations from FEA and MLP reveal the exceptional accuracy attained by all three approaches. As the pioneer study employing three distinct approaches to examine continuous contact mechanics within an orthotropic layer under the influence of gravity, this research constitutes a valuable point of reference for upcoming scholars in the field.

An entropy-based study on the mutational landscape of SARS-CoV-2 in USA: Comparing different variants and revealing co-mutational behavior of proteins

COVID-19 emergency has pushed the international scientific community to use every resource to combat the spread of the virus, to understand its biology and predict its possible evolution in terms of new variants. Since the first SARS-CoV-2 virus nucleotide and amino acid sequences were made available, information theory was used to study how viral information content was changing over time and then trace the evolution of its mutational landscape. In this work we analyzed SARS-CoV-2 sequences collected mainly in the USA in a period from March 2020 until December 2022 and computed mutation profiles of viral proteins over time through an entropy-based approach using Shannon Entropy and Hellinger distance. This representation allows an at-a-glance view of the mutational landscape of viral proteins over time and can provide new insights on the evolution of the virus from different points of view. Non-structural proteins typically showed flat mutation profiles, characterized by a very low Average mutation Entropy, while accessory and structural proteins showed mostly non uniform and high mutation profiles, often coupled with the predominance of variants. Interestingly NSP2 protein, whose function is currently still debated, falls in the same branch of NSP14 and NSP10 in the phylogenetic tree of mutations constructed through correlations of mutation profiles, suggesting a co-evolution of those proteins and a possible functional link with each other. To the best of our knowledge this is the first study based on a massive amount of data (n = 107,939,973) that analyzes from an entropy point of view the mutational landscape of SARS-CoV-2 over time and depicts a mutational temporal profile of each protein of the virus.

SiN‐On‐SOI Optical Phased Array LiDAR for Ultra‐Wide Field of View and 4D Sensing

Abstract3D imaging techniques are facilitating autonomous vehicles to build intelligent systems. Optical phased arrays (OPAs) featured by all solid‐state configurations are becoming a promising solution for 3D imaging. However, the majority of state‐of‐art OPAs commonly suffer from severe power degradation at the edge of the field of view (FoV), resulting in limited effective FoV and deteriorating 3D imaging quality. Here, the chained grating antenna and the vernier concept is synergized to design a novel OPA for realizing a record wide 160°‐FoV 3D imaging. By virtue of the chained antenna, the OPA exhibits less than 3‐dB beam power variation within the 160°FoV. In addition, two OPAs with different pitches are integrated monolithically to form a quasi‐coaxial Vernier OPA transceiver. With the aid of a flat beam power profile provided by the chained antennas, the OPA exhibits uniform beam quality at an arbitrary steering angle. The superior beam steering performance enables the OPA to accomplish 160° wide‐FoV 3D imaging based on the frequency‐modulated continuous‐wave (FMCW) LiDAR scheme. The ranging accuracy is 5.5‐mm. Moreover, the OPA is also applied to velocity measurement for 4D sensing. To the best of knowledge, it is the first experimental implementation of a Vernier OPA LiDAR on 3D imaging to achieve a remarkable FoV.

Study of the irradiation hardening of a Fe9Cr ferritic model alloy by nanoindentations

This paper presents a series of Berkovich indentation results obtained on unirradiated and 7.2 MeV proton irradiated specimens of a Fe9Cr model alloy with an equiaxed ferritic microstructure. Using a energy degrader wheel made of 24 aluminum foils of different thickness, a flat damage profile of about 50 μm resulted from the irradiation, allowing to perform indentations within a volume material that is homogeneously irradiated. The indentation size effect on measured hardness was analyzed with a model based on the disloction-slip distance theory built on the concept of combined spatial frequency of all obstacles to dislocation motion. The effects on hardness of the tip-specimen contact size (or penetration depth), dislocation density and mean distance between irradiation defects were quantified and discussed. The irradiation hardening was characterized by the increase of hardness determined at large penetration depths.

The MAGPI survey: evolution of radial trends in star formation activity across cosmic time

ABSTRACT Using adaptive optics with the Multi-Unit Spectroscopic Explorer on the Very Large Telescope, the Middle Ages Galaxy Properties with Integral Field Spectroscopy survey allows us to study the spatially resolved Universe at a crucial time of ∼4 Gyr ago (z ∼ 0.3) when simulations predict the greatest diversity in evolutionary pathways for galaxies. We investigate the radial trends in the star formation (SF) activity and luminosity-weighted stellar ages as a function of offset from the star-forming main sequence (SFMS) for a total of 294 galaxies. Using both Hα emission and the 4000 Å break (i.e. D4000) as star formation rate (SFR) tracers, we find overall flat radial profiles for galaxies lying on and above the SFMS, suggestive of physical processes that enhance/regulate SF throughout the entire galaxy disc. However, for galaxies lying below the SFMS, we find positive gradients in SF suggestive of inside–out quenching. Placing our results in context with results from other redshift regimes suggests an evolution in radial trends at z ∼ 0.3 for SF galaxies above the SFMS, from uniformly enhanced SF at z ∼ 1 and ∼ 0.3 to centrally enhanced SF at z ∼ 0 (when averaged over a wide range of mass). We also capture higher local SFRs for galaxies below the SFMS compared to that of z ∼ 0, which can be explained by a larger population of quenched satellites in the local Universe and/or different treatments of limitations set by the D4000–sSFR relation.

Preclinical development of EXT608, an investigational parathyroid hormone derivative with extended half-life for the treatment of hypoparathyroidism.

Hypoparathyroidism, a deficiency of parathyroid hormone (PTH), results in hypocalcemia, hyperphosphatemia, and hypercalciuria. The disease is poorly controlled by calcium and vitamin D supplements or native PTH(1-84) replacement therapy. A version of PTH is being developed using D-VITylation technology, whereby vitamin D is conjugated to a therapeutic peptide, which confers a long plasma half-life by virtue of binding to the abundant vitamin D binding protein (DBP). D-VITylation of PTH caused no reduction in activity at the PTHR1 receptor, and resulted in a plasma elimination half-life of 7-15h in rats and 24-32h in cynomolgus monkeys. Analysis of steady-state pharmacokinetics as a function of dose showed flat profiles with smaller peak:trough ratios at low doses, indicative of slower subcutaneous absorption. In thyroparathyroidectomized (TPTx) rats, PTH(1-34)-vitamin D conjugates restored serum calcium and phosphate levels into the normal range over the 24h dosing period, and increased bone turnover markers and reduced bone mineral density. Urinary calcium was initially elevated, but normalized by the end of treatment on day 27. In healthy monkeys, a single dose of PTH(1-34)-vitamin D conjugates elevated serum calcium levels above the normal range for a period of 24-48h while simultaneously reducing urinary calcium. Therefore, the lead compound, EXT608, is a promising candidate as a therapeutic that can truly mimic the endogenous activity of PTH and warrants further study in patients with hypoparathyroidism.

Dynamic characteristics of edge plasma profiles during the opening of edge islands on the J-TEXT tokamak

On the J-TEXT tokamak, the dynamics of edge magnetic topology during the opening of the edge magnetic islands induced by the external Resonant Magnetic Perturbation (RMP) are investigated. The edge island chain is pushed outward by increasing plasma toroidal current to intersect the poloidally and toroidally localized divertor plate, forming an open magnetic island in the Scrape-Off Layer (SOL). The location of the strike points on the divertor plate predicted by the HINT code is in agreement with the experimental observations. The influence of the magnetic topology on edge plasma profiles has also been investigated using Langmuir probes. The properties of edge Te , ne , Pe and Er profiles are studied as function of three magnetic structures in qa -dependence experiments and two magnetic structures in RMP configuration-dependence experiments. Some common features are observed. Inside the edge closed and SOL remnant islands, flat Pe but non-flat Te and ne profiles are detected. When transitioning from the edge closed island to the partially open island with remnant island, the local flat Pe profile is shifted outward accompanied by a narrower flattened Pe region. The steep slopes of Te , ne and Pe are measured in the SOL regions characterized by a long connection length Lc , and the longer Lc , the steeper slopes. Er exhibits a negative well inside the remnant island with infinite Lc and in the SOL regions where Lc significantly exceeds than the electron mean free path λe , but develops a positive value in the SOL regions where Lc is relatively short.