In this paper we study the effects of spatial curvature of the metric on the phase space of vacuum gravity. Particularly, we appropriately choose the variables of the dynamical system, in order for this to be autonomous, and we study the phase space of the resulting theory, focusing on de Sitter, matter and radiation domination fixed points. Our analysis indicates that the effect of spatial curvature on the phase space is radical, since it destabilizes all the stable de Sitter vacua of the flat spacetime vacuum gravity phase space, making the phase space having non-trivial unstable submanifolds. This instability occurs regardless if the spacetime has elliptic or hyperbolic spatial sections, and it is also robust towards the choice of initial conditions. We investigate the source of the instability in the system, and also we discuss the stability of the matter and radiation domination vacua, which, as we demonstrate, are also highly unstable. Our results for de Sitter attractors indicate that the stable de Sitter attractors of the vacuum gravity theory for a flat Universe, are destabilized by the presence of curvature, and this shows that inflation for vacuum gravity in non-flat spacetime is problematic, at least at the phase space level. This result holds true for both elliptic and hyperbolic spacetimes.