In our previous work, the concept of critical region in a generalized Aubry–André model (Ganeshan–Pixley–Das Sarma’s model) has been established. In this work, we find that the critical region can be realized in a one-dimensional flat band lattice with a quasi-periodic potential. It is found that the above flat band lattice model can be reduced to an effective Ganeshan–Pixley–Das Sarma’s model. Depending on various parameter ranges, the effective quasi-periodic potential may be bounded or unbounded. In these two cases, the Lyapunov exponent, mobility edge, and critical indices of localized length are obtained exactly. In this flat band model, the localized-extended, localized-critical and critical-extended transitions can coexist. Furthermore, we find that near the transitions between the bound and unbounded cases, the derivative of Lyapunov exponent of localized states with respect to energy is discontinuous. At the end, the localized states in bounded and unbounded cases can be distinguished from each other by Avila’s acceleration.