Moment frame system is used as lateral load resisting system against seismic loads. So far, a large body of research has been conducted on steel connections and various types of connections including Reduced Beam Section (RBS) and Drilled Flange Connection (DFC). Using RBS results in formation of inelastic deformation in a part of the beam far from the column flange. They have studied the seismic performance of the recently developed DFC as a simple and efficient alternative to mostly used conventional RBS. In this research, the beam flange was drilled in different patterns in terms of the hole diameter. After simulating the models in Abaqus program, the moment-rotation curves were extracted and analyzed numerically. Having obtained the results of the current research regarding the moment connection where beam flanges are drilled, it is evident that drilling holes in the beam flange with clock pattern can better satisfy the flexibility expectations. Moreover, this pattern had higher capability for plastic hinge transfer from the column face compared to the direct pattern. Additionally, this pattern can reduce the bending stress in penetration weld of direct beam to column connection. Thus, the clock pattern of beam flange holes performed better than the straight one.