Abstract This paper introduces a fractal-fractional order model of the human liver (FFOHLM) incorporating a new fractional derivative operator with a generalized exponential kernel, specifically addressing uncertainties. The study delves into verifying the uniqueness and existence of this fuzzy FOHLM using Schauder’s Banach fixed point theorem and the Arzela-Ascoli theorem. It also investigates the fuzzy FOHLM using fixed-point theory and the Picard-Lindelof approach. Moreover, the research analyzes the stability and equilibrium points of the proposed model. To conduct this analysis, the study employs an innovative approach based on a double parametric generalized Adams-Bashforth technique within Newton’s polynomial framework. The numerical results of the proposed fuzzy FOHLM are validated by comparing them with real-world clinical data and other published results, and it shows that the fractal-fractional technique can yield greater efficacy and stimulation compared to the fractional operator when applied to epidemic simulations. Finally, the results of fractional fractal orders are illustrated graphically in a fuzzy environment.