In this paper, we consider the global well-posedness and multi-index stability of pullback random attractors for random fractional retarded lattice FitzHugh-Nagumo systems with nonlinear Wong-Zakai noise and non-autonomous forcing term. We use the idea of Caraballo et al. (2014) [2] to prove the global well-posedness. Based on the global well-posedness of the lattice FitzHugh-Nagumo system, we study the existence, uniqueness and upper semicontinuity of pullback random attractors Aϱδ={Aϱδ(τ,ω):τ∈R,ω∈Ω}. More precisely, we first utilize the method of tail-estimates of solution and Ascoli-Arzelà theorem to prove the existence and uniqueness of pullback random attractors, and then investigate the four types of upper semicontinuity of pullback random attractors: (1) The long time stability of pullback random attractors as the time parameter τ approaches negative infinity; (2) The upper semicontinuity of pullback random attractors as the step-length δ of the Wong-Zakai approximation tends to positive infinity; (3) The upper semicontinuity of pullback random attractors as the delay time ϱ→0; (4) The upper semicontinuity of pullback random attractors from non-autonomous to autonomous.