Purpose: Low back pain is one of the most common musculoskeletal problems. Various complications, such as disability, depression, anxiety, sleep disorders, stress, decreased sexual function and Quality of Life (QoL) are associated with chronic low back pain. The aim of this study was to compare the relationship between demographic, physical fitness, health status, socio-economic indicators, and sexual function indicators on the QoL of women with chronic non-specific low back pain. Methods: The present cross-sectional study was performed in 2020 in the private center of Cyrus Physiotherapy in Tehran, Iran. Thirty married women with non-specific chronic low back pain who were sexually active and living in Tehran were included in the study based on inclusion and exclusion criteria. At first, the goals and process of the study were explained to them and they were given written consent to participate in the study. Then demographic information was recorded and pain, sexual function, and QoL were measured using relevant tools. SPSS software v. 22 was used for statistical tests. Pearson correlation test was used to examine the relationship between the above variables. Results: The Mean±SD age of participants was 38.6±7.48 years. Pearson correlation coefficient showed no statistically significant relationship between the QoL with age (r=-0.172, P=0.364), the number of children (r=-0.166, P=0.382), pain intensity (r=-0.181, P=0.339) and regular exercise (r=-0.159, P=0.402), but there was a statistcally significant relationship between QoL with body mass index (r=-0.406, P=0.026), sexual function score (r=0.379, P=0.039), general health status (r=0.436, P=0.026), education level (r=0.463, P=0.010), and physical fitness status (r=-0.406, P=0.026). Conclusion: In women with chronic non-specific back pain participating in the present study, the lower the body mass index, the higher the level of education and sexual function score, the better overall health and physical fitness status, the better the QoL. However, the results of this study did not confirm the relationships between QoL and age, number of children, pain intensity, and regular exercise. Improving education, health status, fitness status, body mass index, and sexual function index help improve QoL.