Levels of eleven trace metals (Ag, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, Zn and Hg) and four macronutrients (Na, K, Ca and Mg) were estimated in the edible muscle of six commercially exploited fish species using the atomic absorption spectrophotometric method. The fish included in the study were: Argyrops spinifer, Fistularia petimba, Bramnoplaties suppositus, Lepidotriqla omaneaisis, Pampus argentus and Sphyraena obtusata harvested from the south‐west coast of the Arabian Sea along the Karachi coast, Pakistan. All metals have shown substantial increase in their average levels over the past few years. Pampus argentus was found undesirable for human consumption as it contained elevated levels of five metals (As, Cr, Pb, Zn and Hg). This species could be used to monitor marine trace metal pollution since it was found to contain consistently enhanced levels of the industrial metals.