At present, the international economic situation has undergone profound changes. With the globalization of economy, risks are also globalized. At present, regional integration or regionalization has become an important phenomenon in international political economy. The deepening of regional interdependence and the growth of globalization have promoted the expansion of regionalism political and economic perspectives. The "the Belt and Road Initiative (B&R)" strategy is an important decision made by China to adapt to the new normal of economy and face the weak pattern of world economy and trade. In the future, this strategy will be an important supporting point for China's stable, open and efficient economic growth. Based on the new situation of international regional economic cooperation, this paper puts forward an international regional economic decision-making model based on artificial fish swarm algorithm (AFSA), and discusses the selection method of parameters in the model, so as to study the international regional economic cooperation and its effects under the "B&R" strategy. In order to solve it easily, it is transformed linearly and a new model with smaller scale is obtained. The experimental results show that the international regional economic intelligent decision-making model based on AFSA has high stability. The results show the feasibility of the proposed method. The research results have certain theoretical and practical significance for analyzing international political and economic issues, and have certain reference value for international and regional economic cooperation.