The study was carried to find out the effect of natural zinc oxide and nano zinc oxide on the physiological state of common carp. The experiment was divided into 7 treatments that included the control treatment without any addition, the second, third and fourth treatment by adding zinc oxide nanoparticles at concentrations of 25,50 and 75 mg/kg feed respectively, the fifth, sixth and seventh treatment by adding natural zinc oxide at the same concentrations above. The results showed that the T5, T6 and T7 treatments were significantly superior (P>0.01) in the number of red blood cells, while the T2 treatment recorded the lowest number and amounted to 0.95 cells x 106 / mm3, T7 recorded highest range of white blood cells amounted 10.15 cells x 10³ / mm3. The two treatments, T5 and T7, excelled in the size of the packed blood cells, and no significant differences were recorded among the treatments. The two treatments T5 and T7 recorded the highest levels of hemoglobin in the blood, reaching 12.05 and 11.95 g/ dl, respectively. It is clear from the results of the cholesterol values that the T7 recorded the highest concentration, amounting to 127.90 mg/100ml. It can be concluded from the study that the addition of zinc nanoparticles to the fish diet improves the level of performance without causing any harm to the fish and the blood picture was within the normal ranges.