The development of entrepreneurship is considered as a component of social development, which is carried out in three directions: evolutionary, involutional, and abrupt acceleration. The necessity of forming a policy of development of entrepreneurship in Ukraine is indicated and its main tasks are allocated, namely: increasing the volume of production and export of products of Ukrainian enterprises, the formation of new enterprises, ensuring the proper level of satisfaction of domestic demand with goods and services; demonopolization of markets for goods and services and establishment of effective competition in the domestic market; increase and diversification of employment; achievement of an effective fiscal return on business development while maintaining favorable conditions for its development. The general goals of entrepreneurship management include the process of forming a strategy for activity and development and adaptation of business processes of enterprise. It is noted that decision-making by entrepreneurs in conditions of uncertainty should be based on the study of its theoretical foundations, where it is considered in several types: when the results of activities are known and it is possible to predict them; when the results are known, but the probability of them cannot be estimated; when the results are not known and it is not possible to estimate the probability of their occurrence. For the purpose of effective management of the business structure, it is expedient to classify uncertainty by the following types: by methods of determining the probability of occurrence of cases and by the object of uncertainty. Among the main tasks of entrepreneurship management, reducing the likelihood of adverse events and avoiding negative consequences and risks, including strategic ones, are allocated, since the development and implementation of strategic management decisions are the basis for ensuring sustainable development of entrepreneurial entities. It is noted that changes in the institutional environment have an impact on the dynamics of uncertainty. In order to improve business conditions, informal and formal institutions must be aligned, which is a transformation of uncertainty. Directions for the development of entrepreneurial structures have been identified, which should coordinate their actions with the State structures to form an institutional environment. Among such areas, the following are highlighted: creation of commodity exchanges and wholesale markets for products of local producers; formation of market infrastructure of scientific and innovative activities; orientation of commercial banks to the real sector; creation of consulting and leasing firms; development of the stock market, including the formation of the corporate securities market; formation of logistics centers.