Pregnant Women In First Trimester Research Articles

Correlation between hyperemesis gravidarum risk factors and body weight of first-trimester pregnant women

Background: Nausea and vomiting early in pregnancy are experienced by around 70-80% of pregnant women. If nausea and vomiting occur too often, it will become a pathological condition called hyperemesis gravidarum. Many factors trigger hyperemesis gravidarum, necessitating more in-depth research regarding the risk factors for hyperemesis gravidarum and their impact on the weight of pregnant women in the first trimester. Purpose: This study aimed to analyze the correlation between hyperemesis gravidarum risk factors and the body weight of first-trimester pregnant women in East Jakarta. Methods: A quantitative study employing descriptive analysis and a cross-sectional case-control method was conducted, including 84 first-trimester respondents selected using targeted sampling techniques. Data collection was performed using questionnaires, and data analysis was conducted using Chi-square. Results: There is a significant relationship between the risk factor variables for severe morning sickness, namely age, occupation, history of vomiting, anemia, and the outcome, which is the measurement of pregnant women’s weight. Conclusions: There is a relationship between age, occupation, pregnancy, history of vomiting, anemia, and mild stress with the results of weight measurement of pregnant women in the first 3 months of pregnancy.

Clinical Application of Reticulocyte Maturity Indices in Early Diagnosis of Iron Deficiency Anemia in the First Trimester of Pregnancy

Background: Iron deficiency anemia (IDA) is a prevalent global health issue, particularly affecting pregnant females due to increased iron demands during pregnancy. In Pakistan, IDA remains a significant concern, posing challenges to maternal and child health. Early detection and management of iron deficiency are crucial for improving pregnancy outcomes.
 Objective: This study aims to investigate the iron status and associated hematological parameters among pregnant females during the first trimester in Islamabad, Pakistan.
 Methodology : This cross-sectional study, conducted in collaboration with the Pakistan Atomic Energy Commission (PAEC) and the Pakistan Institute of Medical Sciences (PIMS), aimed to investigate the iron status among first-trimester pregnant females in Islamabad, Pakistan.Laboratory investigations encompassed hemoglobin and serum ferritin assays, reticulocyte counts, and other red blood cell parameters. Participants were categorized into distinct iron status groups based on these evaluations. Utilizing SPSS version 25, statistical analysis followed ethical protocols, striving to uncover discrepancies in hematological parameters across the various iron status groups.
 Results : Among 340 first-trimester pregnant women, three iron status groups were identified. Group 1 (n = 102) had low ferritin despite normal Hb, with elevated immature reticulocytes. Group 2 (n = 150) showed normal iron parameters, while Group 3 (n = 88) had high reticulocyte counts. Group 2 exhibited superior erythrocyte indices and higher ferritin levels than Groups 1 and 3. Group 3 displayed the poorest indices and elevated immature reticulocytes. These findings highlight variations in iron status and reticulocyte maturation among pregnant women.
 Conclusion: This study underscores the high prevalence of iron deficiency anemia among first-trimester pregnant females in Islamabad, Pakistan. Variations in red blood cell parameters and serum ferritin levels highlight the importance of early iron status assessment for optimizing maternal and foetal health outcomes.

Pengaruh Aromatherapy Peppermint Terhadap Frekuensi Mual Pada Ibu Hamil Trimester I Di Puskesmas Serpong I

Introduction: Morning sickness is a natural symptom and often occurs in the first trimester of pregnancy in the form of complaints of nausea and vomiting. Nausea usually occurs in the morning but can occur at any time and at night. The incidence of nausea and vomiting in Indonesia is around 10% of pregnant women affected by emesis gravidarum, while the incidence of hyperemesis gravidarum in Banten province reaches 57,429 (24.5%) of 222,789 pregnant women. This study aims to determine the effect of giving peppermint aromatherapy to reducing the frequency of nausea in pregnant women in the first trimester at the Serpong 1 Health Center in 2023. Methods: This study used the Quasi-Experimental designs method with pre-test and post-test without a control group. The sampling technique used is total sampling with a total sample of 22 respondents. Results: The results of the research showed that there was an effect of using peppermint aromatherapy on reducing the frequency of nausea in first-trimester pregnant women based on the Wilcoxon statistical test results obtained p-value 0,004 < 0,005. Discussion: This study concludes that there is an effect of using peppermint aromatherapy on reducing the frequency of nausea in first-trimester pregnant women at the Serpong I Public Health Center in 2023. Suggestions for pregnant women to be able to increase their knowledge and understanding regarding the use of peppermint aromatherapy as a complementary treatment for nausea in the first trimester of pregnancy so that the incidence of nausea and vomiting in pregnant women in the first trimester can be resolved properly.

Predictors of urinary heavy metal concentrations among pregnant women in Jinan, China

BackgroundToxic heavy metal exposure and insufficiency or excess of essential heavy metals may have negative effects on pregnant women’s health and fetal growth. To date, the predictors of pregnant women’s heavy metal exposure levels remain unclear and vary with different regions. The study intended to explore potential predictors of exposure to heavy metals individually and high co-exposure to heavy metal mixtures. MethodsWe recruited 298 pregnant women in first trimester from prenatal clinics in Jinan, Shandong Province, China, and collected spot urine samples and questionnaire data on their demographic characteristics, lifestyle habits, consumption of food and dietary supplement, and residential environment. All urine samples were analyzed for seven heavy metals: cobalt (Co), molybdenum (Mo), strontium (Sr), arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg). ResultsFactors associated with single heavy metal concentration were as follows: a) urinary As, Sr and Cd increased with women’s age respectively; b) pregnant women with higher monthly household income per capita had lower Sr and Mo levels; c) pregnant women with intermittent folic acid supplementation and those not taking tap water as domestic drinking water had lower Sr concentrations; d) Cd was positively linked with consumption frequency of rice; e) Hg was adversely related to consumption frequency of egg and the women who took purified water as domestic drinking water had lower Hg exposure. In addition, pregnant women’s age was positively associated with odds of high co-exposure to Co, As, Sr, Mo, Cd and Pb; while those with an educational level of college had lower odds of high exposure to such a metal mixture compared with those whose educational levels were lower than high school. ConclusionPredictors of single urinary heavy metal concentration included pregnant women’s age (As, Sr and Cd), monthly household income per capita (Sr and Mo), folic acid supplementation (Sr), rice consumption frequency (Cd), egg consumption frequency (Hg) and the type of domestic drinking water (Sr and Hg). Pregnant women with older age, lower educational level tended to have high co-exposure to Co, As, Sr, Mo, Cd and Pb.

Hubungan Status Gizi, Pola Makan, Dan Kecemasan Terhadap Kejadian Hiperemesis Gravidarum Di Rumah Sakit Umum Andhika

Introduction: Hyperemesis gravidarum is a complaint of severe nausea and vomiting more than 10 times a day during pregnancy which can cause fluid deficiency, weight loss, or electrolyte disturbances thereby disrupting daily activities and endangering the fetus in the womb. The incidence of cases of hyperemesis gravidarum is 0,8% to 3,2% of all pregnancies or about 8 to 32 cases per 1000 pregnancies. Nutritional status, diet, and anxiety are factors that can influence the incidence of hyperemesis gravidarum in first-trimester pregnant women. This study aims to determine the relationship between nutritional status, diet, and anxiety with the incidence of hyperemesis gravidarum in Andhika General Hospital. Methods: This study uses a quantitative method of descriptive analytic design with a cross-sectional approach. The sampling technique used was total sampling with a total of 54 respondents. Results: The results showed that there was a significant relationship between nutritional status and the incidence of hyperemesis gravidarum which obtained a p-value of 0,004; dietary pattern and the incidence of hyperemesis gravidarum a p-value of 0,021; anxiety and the incidence of hyperemesis a p-value of 0,010. Discussion: This study concludes that there is a relationship between the variables of nutritional status, diet, and anxiety with the incidence of hyperemesis gravidarum at Andhika General Hospital in 2022. Advice for pregnant women can increase knowledge and understanding of tips for carrying out a healthy pregnancy that can be obtained through health workers and other information media improve nutritional status by improving diet according to the needs of pregnant women recommended by health workers such as consuming balanced nutrition (protein, carbohydrates, fat, minerals, and vitamins) during pregnancy.

The Influence of the Combination of Acupressure on the Meridian Point P6 and Peppermint Aromatherapy Inhalation on the Reduction of Nausea and Vomiting Frequency in First-Trimester Pregnant Women

Nausea and vomiting disorders during pregnancy, particularly in the first trimester, often impact the quality of life for pregnant women, with 50-90% of cases occurring during this period. Besides affecting maternal health, these disorders also influence fetal growth and development. Management can be achieved through pharmacological and non-pharmacological methods, including the combination of acupressure at Meridian Point P6 and inhalation of peppermint aromatherapy.This research aims to evaluate the impact of this combination on reducing the frequency of nausea and vomiting in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung. Utilizing a quasi-experimental method, involving 12 first-trimester pregnant women experiencing nausea and vomiting at the mentioned hospital, the study results demonstrate that the combination of acupressure and peppermint aromatherapy significantly reduces the frequency of these symptoms. Statistical analysis using the paired t-test yields a p-value of 0.012. In conclusion, this combination proves effective in addressing nausea and vomiting issues in first-trimester pregnant women at RSHM Yusuf Kalibalangan in North Lampung, offering new insights into non-pharmacological options for improving the well-being of pregnant women.

The Relationship between Pregnant Mothers' Behavior and Adherence to Folic Acid Consumption

Introduction: Pregnancy, defined as the state in which a woman carries an embryo in her uterus for approximately 38 to 40 weeks from the first day of menstruation. According to WHO standards, the normal pregnancy period ranges from 37 to 42 weeks. Prenatal care is highly recommended to reduce the risk of fetal death and complications. Folic acid supplementation during pregnancy is considered crucial in preventing neural tube defects and congenital abnormalities, with WHO recommending supplementation as a preventive measure. Despite evolving information on the benefits of folic acid, the compliance level of pregnant women remains low. Therefore, this research becomes an interesting exploration. The research aims to explore the behavior of pregnant women regarding compliance with folic acid consumption in the working area of Malawei Public Health Center, Manoi District, Sorong City. Methods: The applied method is an analytical design with a Cross-Sectional approach, conducted from May to July 2023. The study population involved 197 first-trimester pregnant women, with a sample size of 70 respondents selected using accidental sampling. Data were analyzed using the chi-square test. Results: Findings indicate that the majority of respondents are aged 20-35 years, unemployed, have a high school education, and income ranging from Rp1,000,000 to Rp5,000,000. 58.6% of pregnant women exhibited sufficient behavior, and 85.7% of them were classified as compliant in consuming folic acid. The chi-square test analysis shows a significant relationship between the behavior of first-trimester pregnant women and compliance with folic acid consumption, with a p-value of 0.004, indicating that the p-value is < 0.05. Conclusion: There is a correlation between the behavior of pregnant women and the extent to which they comply with folic acid consumption. The implication of this research is the need for the development of interventions or health education programs focused on improving the behavior of pregnant women to enhance compliance with folic acid consumption during pregnancy.

A Study Estimating the Serum TSH Levels in First Trimester Pregnant Women

Background Pregnancy is a physiological condition among women. Pregnancy brings about major changes in the hormonal levels. Thyroid stimulating hormone is a hormone produced by anterior pituitary. TSH provides the most common sensitive index to reliably detect thyroid function abnormalities.ObjectiveThe goal of this study was to estimate the levels of serum TSH at first trimester in pregnant women in the department of Biochemistry St. Johnrsquos Medical College amp Hospital and compare with the biological reference intervals as established in the laboratory. Methodology This retrospective study was conducted from January to December 2021 in the department of Biochemistry St. Johnrsquos Medical College amp Hospital. Lab data review of pregnant women has been analysed for serum TSH. The study included 228 pregnant women in their first trimester aged between 20 and 35 years. Serum TSH levels were measured using the ABBOTT ARCHITECT CI8200 through Chemiluminometric Immunoassay. The collected data underwent analysis and comparison to derive descriptive statistics.Result A total of 228 pregnant women in the first trimester fulfilling the inclusion criteria were included. Maternal age of the study population was 20-35 years. Among the pregnant women 12 5.3 women showed low values for TSH lt0.35 microIUMl 11 4.8 women showed higher values for TSH gt4.94 microIUmL and 205 89.9 showed normal TSH levels during first trimester. In this study the mean TSH level in pregnant women was found to be 1.94plusmn1.50 microIUmL. The median TSH levels was 1.51 microIUmL 2.5th and 97.5th percentiles P2.5-P97.5 0.23-5.86 microIUmL.Conclusion The observed connection between aberrant TSH serum levels during the first trimester and adverse pregnancy outcomes underscores the necessity for proactive screening. Identifying pregnant women with elevated or reduced TSH levels early on holds significant potential for preventing complications. The incorporation of such screening protocols can yield a range of benefits including timely interventions and enhanced management strategies to mitigate adverse outcomes. Our research contributes to the growing body of evidence supporting TSH screening during early pregnancy emphasizing its pivotal role in safeguarding maternal and foetal health.

Drug Exposure During Pregnancy: A Case-Control Study from a Primary Care Database.

Drug exposure during pregnancy is frequent, even more during first trimester as pregnant women might not be aware of their condition. We used available electronic health records (EHRs) to describe the use of medications during the first trimester in pregnant women and to compare drug exposure between those women who had an abortion (either elective or spontaneous) compared to those who had live births. Case-control study of abortions, either elective or spontaneous (cases), and live birth pregnancies (controls) in Sistema d'Informació per al Desenvolupament de la Investigació en Atenció Primària (Catalan Primary Health electronic health records) from 2012 to 2020. Exposure to drugs during first trimester of pregnancy was considered to estimate the association with abortion by conditional logistic regression and adjusted by health conditions and other drugs exposure. Sixty thousand three hundred fifty episodes of abortions were matched to 118,085 live birth pregnancy episodes. Cases had higher rates of alcohol intake (9.9% vs. 7.2%, p < 0.001), smoking (4.5% vs. 3.6%, p < 0.001), and previous abortions (9.9% vs. 7.8%, p < 0.001). Anxiety (30.3% and 25.1%, p < 0.001), respiratory diseases (10.6% and 9.2%, p < 0.001), and migraine (8.2% and 7.3%, p < 0.001), for cases and controls, respectively, were the most frequent baseline conditions. Cases had lower rate of drug exposure, 40,148 (66.5%) versus 80,449 (68.1%), p < 0.001. Association with abortion was found for systemic antihistamines (adjusted odds ratio [ORadj] 1.23, 95% confidence interval [CI] 1.19-1.27), antidepressants (ORadj 1.11, 95% CI 1.06-1.17), anxiolytics (ORadj 1.31, 95% CI 1.26-1.73), and nonsteroidal anti-inflammatory drugs (ORadj 1. 63, 95% CI 1.59-1.67). These high rates of drug exposures during the first trimester of pregnancy highlights the relevance of informed prescription to women with childbearing potential.

The Influence of Hemoglobin Levels and Nutritional Status of First-Trimester Pregnant Woman with Low Birth Weight

Premature birth is identified as the most significant contributor to infant mortality. The weight of a newborn baby is determined by nutritional status at the time of conception. Pregnant women who are malnourished and experience physical weakness will endanger the mother's life and threaten the safety of the fetuce. LBW can be caused by anemia, inadherence to antenatal care, mothers with chronic diseases and smoking. This study aimed to determine the influence of hemoglobin levels and nutritional status of first-trimester pregnant women with low birth weight events. This type of quantitative research is a retrospective design. The population are mothers who gave birth at the Kabuh Community Health Center, Jombang Regency, in April 2019 obtained a sample of 39 respondents using a purposive sampling, with inclusion criteria birthing mothers have a KIA book. The data were analyzed using logistic regression. The results showed that almost all (79.5%) 31 pregnant women were not anaemic, almost all (84.6%) 33 pregnant women had normal nutritional status and almost all (76.9) babies were born with average weight, namely 30 respondents. There is a relationship between Hemoglobin levels in pregnant women and the incidence of LBW with a value of p = 0.000. There is a relationship between the nutritional status of pregnant women and the incidence of LBW with a value of p = 0.000. The most dominant factor is Hb levels (p=0.001 exp B:30) Pregnant women are anaemic, one of the factors causing poor nutritional status. Nutritional status lacks calorie energy, inhibiting the fetus's nutritional intake, resulting in premature labour or disruption of fetal growth.

Factors related to HbA1c in the first trimester of pregnancy

The prevalence of gestational diabetes mellitus (GDM) in the world is 16.2% of live births associated with hyperglycemia in pregnancy, and 7.4% are caused by type 1 or 2 diabetes which is detected for the first-time during pregnancy. The prevalence of GDM in Indonesia reaches 3.6% and the highest rate is found in the Special Province of Yogyakarta (2.6%). One of the risk factors for GDM is excess nutrition which is influenced by daily intake. This study aims to determine the relationship between nutritional intake and body mass index (BMI) with HbA1c levels in first-trimester pregnant women. This study used a cross-sectional design. A simple random sampling with inclusion and exclusion criteria was employed, involving 47 pregnant women as subjects. Nutritional intake was measured with the semi-quantitative food frequency questionnaire (SQ-FFQ). The nutritional status of pregnant women is measured by BMI. HbA1c was measured by the turbidimetric inhibition immunoassay (TINIA) method. Analysis of research data using the Pearson product-moment correlation test and rank Spearman. The results of this study stated that there was a relationship between nutritional intake and BMI with HbA1c levels. Diagnosis of GDM and appropriate intervention can reduce the risk of complications of diabetes mellitus (DM).

Acupressure Technique Point P6 (Nei Guan) to Reduce Nausea and Vomiting and Point L14 (Hegu) to Reduce Anxiety in Pregnant Women

Nausea, vomiting, and anxiety can affect the food intake of pregnant women, and nutritional deficiencies can disrupt the growth and development of the fetus in the womb. This study aims to determine the difference between pre-test and post-test after applying acupressure techniques at point P6 (Nei Guan) to reduce nausea and vomiting, and at point L14 (Hegu) to reduce anxiety. The research method used a pure experimental design. The population consisted of first-trimester pregnant women, with a sample of 30 pregnant women divided into three groups of 10 each. Groups 1 and 2 were given acupressure techniques at points P6 (Nei Guan) and L14 (Hegu) for 15 minutes every morning upon waking for 7 days, while group 3 received no treatment. Data on the acupressure technique was collected through observation, using a checklist instrument. Data on nausea and vomiting was obtained from a questionnaire. Anxiety data was obtained from the Hamilton Rating Scale for Anxiety (HRS-A). The Wilcoxon analysis was used. Group 1 had an average decrease of 1.20 in nausea and a decrease of 1.10 in anxiety. Group 2 had an average decrease of 1.20 in nausea and a decrease of 1.50 in anxiety. Group 1 showed no difference in nausea but showed a difference in anxiety. Group 2 showed a difference in both nausea and anxiety.

A comparison study of maternal and perinatal outcomes with gestational diabetes mellitus, impaired glucose tolerance, and normal glucose tolerance

Gestational diabetes mellitus (GDM) and impaired glucose tolerance (IGT), which are growing health concerns globally, are the most common metabolic and endocrine perinatal issues. It is a contentious entity with competing policies and procedures. Most physicians in the United States employ a two-step procedure, starting with a 50-g non-fasting oral glucose challenge test at 24 to 28 weeks and moving on to a 100-g fasting test for women who receive a positive screening result. Instead, doctors use the Diabetes in Pregnancy Study Group India (DIPSI) technique and conduct just a 75-g, two-hour fasting oral glucose tolerance test. The prospective observational study was approved by the hospital's institutional ethics committee and was conducted from April 2020 to September 2021 at the department of obstetrics and gynecology at Stanley Medical College Hospital in Chennai, Tamil Nadu, India. The patients were chosen in accordance with the inclusion criteria, which called for first-trimester pregnant women without diabetes mellitus. Both oral and written consent were also obtained. DIPSI performed the screening. The WHO standards have been updated to be a one-step process with a single glycemic value. According to the results of this study, GDM is linked to harmful consequences that might affect both the mother and the foetus. The short- and long-term consequences in both the mother and the newborn can be greatly reduced with early detection and timely therapy of this illness. In this study, birth weights ranging from 2.5 to 3.5 kg were the same for GDM and IGT moms. IGT mothers should also be followed up on, and we should be more watchful at birth, even though we monitor GDM mothers.

Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia.

Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and functions at implantation, but manifestation of its phenotypes is in late pregnancy. There is no reliable method for early prediction and treatment of EOPE. Adrenomedullin (ADM) is an abundant placental peptide in early pregnancy. Integrated single-cell sequencing and spatial transcriptomics confirm a high ADM expression in the human villous cytotrophoblast and syncytiotrophoblast. The levels of ADM in chorionic villi and serum were lower in first-trimester pregnant women who later developed EOPE than those with normotensive pregnancy. ADM stimulates differentiation of trophoblast stem cells and trophoblast organoids in vitro. In pregnant mice, placenta-specific ADM suppression led to EOPE-like phenotypes. The EOPE-like phenotypes in a mouse PE model were reduced by a placenta-specific nanoparticle-based forced expression of ADM. Our study reveals the roles of trophoblastic ADM in placental development, EOPE pathogenesis, and its potential clinical uses.

Pengaruh Pemberian Aromaterapi Lemon dan Minuman Jahe Terhadap Pengurangan Emesis Gravidarum pada Ibu Hamil Trimester I

Emesis gravidarum, or excessive nausea and vomiting during early pregnancy, is a common issue frequently experienced by pregnant women. Most cases of pregnancy-related nausea and vomiting can be managed through outpatient care and the use of sedatives and anti-emetics. However, the treatment of hyperemesis gravidarum, a more severe form of pregnancy-related nausea and vomiting, can be approached both pharmacologically and non-pharmacologically. One non-pharmacological approach involves the use of aromatherapy with lemon essential oil and the consumption of ginger-infused beverages. This study aims to analyze the effects of lemon aromatherapy and ginger beverage consumption on reducing emesis gravidarum symptoms in first-trimester pregnant women at the Kaubun Health Center. The research employs a Pretest-Posttest without Control Group design, with a sample of 30 first-trimester pregnant respondents. Statistical analysis using the Wilcoxon test reveals a significant difference in the reduction of emesis gravidarum symptoms between the group receiving lemon aromatherapy and the group consuming ginger beverages, with a p-value of 0.001. Based on these findings, it can be concluded that the administration of lemon aromatherapy and ginger beverage consumption has a positive impact on reducing emesis gravidarum symptoms in first-trimester pregnant women. This non-pharmacological approach can be an effective alternative for managing emesis gravidarum during early pregnancy.

Frequency of Vitamin D Deficiency in Patients with Bacterial Vaginosis during First Trimester of Pregnancy

Bacterial vaginosis (BV) is an infection mainly results due to overabundance of germs. Because it affects a variety of immune system functions, it is crucial for BV. In order to timely assess, rationalize prospectively, and manage patients to combat vitamin D deficiency in bacterial vaginosis, this study planned to conduct on patients with bacterial vaginosis in relation to vitamin D deficiency, evaluate the magnitude, and generate local data. Objective: To determine the frequency of vitamin D deficiency in patients with bacterial vaginosis during first trimester of pregnancy. Methods: This cross-sectional study was conducted at Gynecology and Obstetrics department of Shaikh Zaid Women Hospital, SMBBMU Larkana from 10-September-2018 to 10-march-2019. A total of 192 pregnant women of first trimester with bacterial vaginosis were selected for this study. All the pregnant ladies with bacterial vaginosis were recruited and entered in the study and was screened for vitamin D deficiency. The data were collected on prepared proforma. Results: The age range from 25 to 35 years with a mean of 29.8±6.5 years, with mean gestational age of 8.09 ±2.29 weeks. Frequency of vitamin D deficiency was 47.4% in women with bacterial vaginosis in their first trimester. Conclusions: Findings of our study suggest association between vitamin D insufficiencies with BV during first trimester of pregnancy.

Đánh giá kiến thức, thái độ sử dụng các xét nghiệm sàng lọc trước sinh của phụ nữ mang thai trong 3 tháng đầu thai kỳ tại quận Bắc Từ Liêm năm 2022

Objective: Describe knowledge, attitudes and related factors as well as the readiness regarding opting prenatal screening tests of first-trimester pregnant women in North Tu Liem District, Hanoi in 2022. Analyzing some factors affect knowledge and attitudes toward the use of prenatal screening tests. Methods: A quantitative, cross-sectional study was applied, using a 5-point Likert scale to assess. SPSS20 software was used to analyzed the answers of 150 participants. Main findings: The mean score of knowledge and attitudes ranged from 3,47 – 3,69 and 3,34 – 3,57 respectively on a 5-point Likert scale. In addition, Ultrasound was the most well-known test (100% women knew about it) and they mainly accessed prenatal screening’s information through Obstetricians (119/150 options). Notably, educational level, employment status and place of residence significantly affected knowledge and attitudes toward opting prenatal screening tests while the number of children was unrelated. Conclusions: First-trimester pregnant women in North Tu Liem District, Hanoi had a good level of knowledge and relatively positive attitudes toward the use of prenatal screening tests. Pregnant women with a high level of education, having an occupation and living in the urban areas have better knowledge and attitudes toward using prenatal screening tests. Keywords: Assessment, knowledge, attitudes, pregnant women, prenatal screening tests, first-trimester, North Tu Liem.

Hubungan Sikap Ibu dan Dukungan Suami dengan Kejadian Hiperemesis Gravidarum Grade II-III

Hyperemesis gravidarum, which often occurs in the early stages of pregnancy, can be quite disruptive. However, the majority of pregnancy-related nausea and vomiting can be managed with outpatient care and the use of antiemetic medications. In this context, social support, especially from spouses, and the mother's attitude toward hyperemesis gravidarum symptoms can play a role in preventing further development of this condition. This research was conducted to examine the relationship between the mother's attitude and spousal support with the occurrence of Grade II-III hyperemesis gravidarum at the Kaubun Health Center in 2023. The research method used was a correlation study with a cross-sectional approach. The study population involved 32 first-trimester pregnant women who visited the Kaubun Health Center in January 2023, and the entire population was sampled. The results of the statistical analysis using the chi-square test indicated a significant relationship between the mother's attitude (p-value = 0.000) and spousal support (p-value = 0.006) with the occurrence of hyperemesis gravidarum. Therefore, the conclusion of this research is that the mother's attitude and spousal support are associated with the occurrence of Grade II-III hyperemesis gravidarum at the Kaubun Health Center in 2023. Husbands play a crucial role in providing support, understanding, and positive feelings to wives experiencing hyperemesis gravidarum, helping wives feel comfortable and capable of managing these symptoms. A deeper understanding of this condition enables husbands to provide more effective support, contributing to the prevention and management of hyperemesis gravidarum during pregnancy.

Implication of red meat consumption habits in serum uric acid levels and mood disorders among first-trimester pregnant women

BackgroundDietary pattern involving meat consumption has an association with serum uric acid level which subsequently has an impact on moods. However, this relationship is not clearly established in pregnant women, particularly those who are accustomed to daily meat consumption.ObjectiveThis study investigated the relationship between red meat consumption and uric acid level and the subsequent impact on mood disorders in 1st trimester pregnant women.MethodologyA total of 92 pregnant women in their first trimester (8–12 weeks), were selected for this study. Socio-demographic characteristics including age, body mass index (BMI), educational qualification, sleep hours, blood pressure and exercise status were recorded. To assess meat consumption, classification based on the recruited population consumption was divided into low and high meat consumption groups. Serum uric acid level was estimated in plasma. Mood disorder, namely, depression and anxiety were assessed using a self-reported Hospital Anxiety and Depression Scale (HADS) questionnaire. Collected data was analysed using different statistical tools.ResultsLogistic regression analysis showed higher odds of depression (OR = 0.059, 95% CI 0.02–0.172, p < 0.001) and anxiety (OR = 0.144, 95% CI 0.055–0.375, p < 0.001) in the high meat consumption group. Further, the potential confounders, high BMI and less exercise increased the odds of depression and anxiety in high meat consumption groups. Linear regression analysis revealed a significant influence of meat consumption on uric acid level (F (1, 90) = 305.385, p < 0.01).ConclusionsThe study recommends regular clinical screening of mood disorders, and recommends reasonable consumption of lean meat and/or replacing some portions with fish, as well as, a commitment to eating a healthy, balanced diet. It also suggests extensive studies because it could be linked to postpartum mood disorders among those who consume red meat every day.

First trimester SHARP1 and second-trimester uterine artery Doppler to predict preeclampsia

Objectives The objective of this study was to identify the predictive value of the first-trimester serum SHARP1 level and the second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. Methods A prospective study including singleton pregnancy presenting at an antenatal clinic, King Chulalongkorn Memorial Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University from 2019–March 2020 was conducted. Serum SHARP1 was collected at the gestational age (GA) of 11–13+6 weeks, and transabdominal uterine artery Doppler ultrasound was performed at GA of 18–24 weeks. Serum SHARP1 level and uterine artery pulsatility index (PI) were combined to calculate the predictive value for preeclampsia detection. Results 288 pregnant women were enrolled in the first trimester, but only 249 participants completed the study. Thirteen patients had preeclampsia (5.2%), which three cases (1.2%) had early-onset preeclampsia. The median serum SHARP1 level in the first trimester of pregnant women with preeclampsia was lower than the normal pregnancy group (1392 pg/ml vs. 1941 pg/ml, p = 0.046). The second-trimester uterine artery PI and prevalence of early diastolic notching were higher in the preeclampsia group than in the normal pregnancy group (p = 0.029 and p = 0.001, respectively). When the first-trimester serum SHARP1 level is combined with the second-trimester uterine artery PI, the sensitivity, specificity, PPV, and NPV for preeclampsia prediction were 84.6%, 47.5%, 8.2%, and 98.3%, respectively. Conclusions This study demonstrated that serum SHARP1 level in the first trimester combined with the uterine artery PI in the second trimester had good sensitivity to predict preeclampsia.