First Time In Man Research Articles

PATHS OF LYSINE DEGRADATION IN PATIENTS WITH HYPERLYSINEMIA

Study of lysine metabolites in the urine of two children with hyperlysinemia indicates that several pathways for lysine breakdown exist in man. Two of these are demonstrated to be functioning and are shown to be of secondary importance for lysine degradation in these children. One of the paths, via homocitrulline and homoarginine, has been demonstrated for humans by others. The second, through \g=elunate\-N-acetyl-L-lysine, is documented here for the first time in man. These pathways are not the site of the metabolic block, and another path of lysine degradation must be postulated as the site of the metabolic block in these patients with hyperlysinemia.

Clinical Evaluation of Drugs

THE I HE INTRODUCTION of a new chemical agent into the human organism can be as exciting, and at times as hazardous, as major surgery. It is, therefore, imperative that every possible means be taken to insure the maximum degree of safety while, at the same time, every available bit of information is secured. There are many factors which must be taken into consideration when a new agent is to be evaluated for the first time in man. In general, these can be divided into (1) the investigator and his responsibilities, (2) the place of investigation, (3) the subject, (4) the design of the study, (5) the pharmacological and clinical principles essential in assessing the safety of a drug, and (6) the legal, moral, and administrative aspects.1 Investigator The most important of these factors is the investigator. The field of drug evaluation in humans requires individuals with highest motivation,

The Contributions of Electronmicroscopy to the Understanding of Renal Diseases.

s1 April 1963The Contributions of Electronmicroscopy to the Understanding of Renal Diseases.C. L. Pirani, M.D.C. L. Pirani, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-742_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of percutaneous needle biopsy has opened a new era in the study of kidney diseases. The value of this method in diagnosis, treatment, and prognosis is well established. This technique has also permitted, for the first time in man, the widespread application of electronmicroscopy to the study of the abnormal kidney.Through electronmicroscopy, the fine structure of the nephron has been elucidated in all its complexity, providing a sounder morphologic basis for the understanding of renal function. Electronmicroscopic studies have clarified to a considerable extent the glomerular changes occurring in a variety of renal diseases. The various types... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Ill. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 742-742KeywordsBiopsyKidneysNephronsRenal diseases Issue Published: 1 April 1963 PDF DownloadLoading ...

Chronic fluorine poisoning. Presentation of a case with renal insufficiency

SummaryAn isolated case of chronic fluorine intoxication with ankylosis of the vertebral column is presented. This patient got also a renal insufficiency with an histologic picture of chronic interstitial nephritis. These lesions resembling those described in experimental fluorine intoxication in the animal, and other causes of renal insufficiency being absent, we believe to have demonstrated the nephrotoxicity of fluorine for the first time in man.