First-order Statistics Research Articles

Frequency Domain-Oriented Complex Graph Neural Networks for Graph Classification.

Graph neural networks (GNNs) could directly deal with the data of graph structure. Current GNNs are confined to the spatial domain and learn real low-dimensional embeddings in graph classification tasks. In this article, we explore frequency domain-oriented complex GNNs in which the node's embedding in each layer is a complex vector. The difficulty lies in the design of graph pooling and we propose a mirror-connected design with two crucial problems: parameter reduction problem and complex gradient backpropagation problem. To deal with the former problem, we propose the notion of squared singular value pooling (SSVP) and prove that the representation power of SSVP followed by a fully connected layer with nonnegative weights is exactly equivalent to that of a mirror-connected layer. To resolve the latter problem, we provide an alternative feasible method to solve singular values of complex embeddings with a theoretical guarantee. Finally, we propose a mixture of pooling strategies in which first-order statistics information is employed to enrich the last low-dimensional representation. Experiments on benchmarks demonstrate the effectiveness of the complex GNNs with mirror-connected layers.

CT-based radiomics analysis to predict local progression of recurrent colorectal liver metastases after microwave ablation

The objective of this study is to establish and validate a radiomics nomogram for prediction of local tumor progression (LTP) after microwave ablation (MWA) for recurrent colorectal liver metastases (CRLM) after hepatic resection. We included 318 consecutive recurrent CRLM patients (216 of training while 102 of validation cohort) with contrast-enhanced computerized tomography images treated with MWA between January 2014 and October 2018. Support vector machine-generated radiomics signature was incorporated together with clinical information to establish a radiomics nomogram. Our constructed radiomics signature including 15 features (first-order intensity statistics features, shape and size-based features, gray level size zone/dependence matrix features) performed well in assessing LTP for both cohorts. With regard to its predictive performance, its C-index was 0.912, compared to the clinical or radiomics models only (c-statistic 0.89 and 0.75, respectively) in the training cohort. In the validation cohort, the radiomics nomogram had better performance (area under the curve = 0.89) compared to the radiomics and clinical models (0.85 and 0.69). According to decision curve analysis, our as-constructed radiomics nomogram showed high clinical utility. As revealed by survival analysis, LTP showed worse progression-free survival (3-year progression-free survival 42.6% vs 78.4%, P < .01). High-risk patients identified using this radiomics signature exhibited worse LTP compared with low-risk patients (3-year LTP 80.2% vs 48.6%, P < .01). A radiomics-based nomogram of pre-ablation computerized tomography imaging may be the precious biomarker model for predicting LTP and personalized risk stratification for recurrent CRLM after hepatic resection treated by MWA.

A hybrid lightweight breast cancer classification framework using the histopathological images

A crucial element in the diagnosis of breast cancer is the utilization of a classification method that is efficient, lightweight, and precise. Convolutional neural networks (CNNs) have garnered attention as a viable approach for classifying histopathological images. However, deeper and wider models tend to rely on first-order statistics, demanding substantial computational resources and struggling with fixed kernel dimensions that limit encompassing diverse resolution data, thereby degrading the model’s performance during testing. This study introduces BCHI-CovNet, a novel lightweight artificial intelligence (AI) model for histopathological breast image classification. Firstly, a novel multiscale depth-wise separable convolution is proposed. It is introduced to split input tensors into distinct tensor fragments, each subject to unique kernel sizes integrating various kernel sizes within one depth-wise convolution to capture both low- and high-resolution patterns. Secondly, an additional pooling module is introduced to capture extensive second-order statistical information across the channels and spatial dimensions. This module works in tandem with an innovative multi-head self-attention mechanism to capture the long-range pixels contributing significantly to the learning process, yielding distinctive and discriminative features that further enrich representation and introduce pixel diversity during training. These novel designs substantially reduce computational complexities regarding model parameters and FLOPs, which is crucial for resource-constrained medical devices. The outcomes achieved by employing the suggested model on two openly accessible datasets for breast cancer histopathological images reveal noteworthy performance. Specifically, the proposed approach attains high levels of accuracy: 99.15 % at 40× magnification, 99.08 % at 100× magnification, 99.22 % at 200× magnification, and 98.87 % at 400× magnification on the BreaKHis dataset. Additionally, it achieves an accuracy of 99.38 % on the BACH dataset. These results highlight the exceptional effectiveness and practical promise of BCHI-CovNet for the classification of breast cancer histopathological images.

Machine Learning Radiomics Signature for Differentiating Lymphoma versus Benign Splenomegaly on CT.

We aimed to develop and validate a preoperative CT-based radiomics signature for differentiating lymphoma versus benign splenomegaly. We retrospectively analyzed CT studies from 139 patients (age range 26-93 years, 43% female) between 2011 and 2019 with histopathological diagnosis of the spleen (19 lymphoma, 120 benign) and divided them into developing (n = 79) and testing (n = 60) datasets. The volumetric radiomic features were extracted from manual segmentation of the whole spleen on venous-phase CT imaging using PyRadiomics package. LASSO regression was applied for feature selection and development of the radiomic signature, which was interrogated with the complete blood cell count and differential count. All p values < 0.05 were considered to be significant. Seven features were selected for constructing the radiomic signature after feature selection, including first-order statistics (10th percentile and Robust Mean Absolute Deviation), shape-based (Surface Area), and texture features (Correlation, MCC, Small Area Low Gray-level Emphasis and Low Gray-level Zone Emphasis). The radiomic signature achieved an excellent diagnostic accuracy of 97%, sensitivity of 89%, and specificity of 98%, distinguishing lymphoma versus benign splenomegaly in the testing dataset. The radiomic signature significantly correlated with the platelet and segmented neutrophil percentage. CT-based radiomics signature can be useful in distinguishing lymphoma versus benign splenomegaly and can reflect the changes in underlying blood profiles.

Textural Analysis of Magnetic Resonance Images as an Additional Evaluation Tool of Parotid Glands in Sjögren-Primarily Findings.

Magnetic Resonance Imaging (MRI) plays a leading role in diagnosing soft tissue pathologies, especially in the head and neck. It is increasingly popular for evaluating salivary gland issues like neoplasms and Sjogren's Syndrome. Advanced MRI methods, including MRI sialography and texture analysis, offer non-invasive alternatives, enhancing MRI's role. This study focused on the relationship between the apparent diffusion coefficient (ADC) and T2-weighted MRI sialography and texture analysis (TA) of parotid glands in children with and without Sjogren's Syndrome (SS). Using 3.0 Tesla MRI with DWI and T2-weighted imaging, expended texture analysis, first-order statistics (FSOs), second-order, and higher-order statistics were conducted. The results showed significant differences in parotid ADC values, with lower values in the SS group, particularly in cases of higher disease activity. Lower kurtosis values were associated with more severe Tonami Scale grades. FSO parameters correlated well with the texture analysis from T2-weighted images, indicating promise in grading parotid gland inflammation. However, further research is needed to understand the impact of variables like binning and region of interest (ROI) size. This study highlights the potential of texture analysis for assessing parotid gland inflammation and emphasizes the need for more investigations in this area.

EPCO-31. THE PROGNOSTIC IMPLICATIONS OF THE RELATIVE ABUNDANCE OF DECONVOLVED TUMOR AND NON-TUMORAL SUBPOPULATIONS IN MULTI-REGIONAL BIOPSIES OF HIGH GRADE GLIOMA WITH BULK RNA-SEQ

Abstract High-grade glioma continues to have dismal survival owing in part to its intra- and inter-patient heterogeneity. Standard clinical protocol collects tumor samples with the aim of providing or confirming a diagnosis and determining the status of a few key genes (e.g. IDH1, MGMT). However, this protocol is unable to capture the diversity within tumor regions, immune expression or normal cell abundances that play key roles in the development of the disease. To overcome this, during surgery we collect image-localized multi-regional biopsies to characterize this disease heterogeneity. Data collection is ongoing, and we currently have 202 samples from 58 patients with available bulk RNA-Seq. With a single-cell reference dataset from Columbia University, we used CIBERSORTx, a deconvolution method, to predict relative abundances of 7 normal, 6 glioma, and 5 immune cell subpopulations for each sample. We used Cox proportional hazard models with first-order statistics (mean, minimum, maximum) of abundances within patients to determine whether these are prognostic, then used TCGA RNA-Seq data to validate these findings. We found that one glioma proneural subtype was significantly beneficial for patient survival relative to other glioma subtypes across all statistics (and showed significance in TCGA). Proliferative and mesenchymal glioma subtypes also showed significance for one or two of the calculated statistics. Oligodendrocyte progenitor cell abundances were consistently significantly beneficial for patient survival in our cohort, while an increased abundance of abnormal (reactive) astrocytes is associated with poor prognosis. We also ran these analyses within invasive margin and core tumor regions to determine location-specific population abundances associated with patient survival. In conclusion, understanding the in vivo diversity of cellular subpopulations within high grade glioma is important for treatment stratification and patient benefit.

Optimal margin distribution matrix machine

As a proficient matrix classifier, Support Matrix Machine (SMM) utilizes the structural information within matrices to achieve remarkable classification results. Recent theoretical advancements have emphasized the importance of optimizing margin distribution (MD) for improving generalization performance. Regrettably, this crucial aspect has been neglected within the framework of the SMM. Furthermore, SMM inherits the hinge loss function from Support Vector Machine (SVM), which has a detrimental impact on its robustness to noise interference. To address these issues, we propose a novel matrix classification method called Optimal Margin Distribution Matrix Machine (ODMM) by introducing a novel MD-based loss function. Our model not only leverages the structural information of the matrix through the low-rank condition but also enhances the generalization performance of the classifier by optimizing the margin distribution. Specifically, we derive the MD-based loss function based on the first-order and second-order statistics of the margin, replacing the traditional hinge loss function in SMM. Additionally, to solve the optimization problem of ODMM, we developed an algorithm based on the Alternating Direction Method of Multipliers (ADMM) framework. Finally, we demonstrate the superior performance of our proposed ODMM through comprehensive comparative experimental analysis.

Plane-based clustering with asymmetric distribution loss

Ramp-based twin support vector clustering (RampTWSVC) is a powerful clustering method, which measures the within-cluster and between-cluster scatter by the bounded ramp functions. However, the ramp loss is a symmetric function and it does not consider the data distribution, which makes the RampTWSVC not robust enough to deal with noisy datasets. In this paper, we construct an asymmetric distribution loss function and propose a novel plane-based clustering with asymmetric distribution loss (ADPC). The asymmetric distribution loss function combined the ramp loss with first-order and second-order statistics, it inherits the advantages of ramp loss function and captures the data distribution precisely, which makes ADPC more robust to the samples far from the cluster center plane. Moreover, two adjusting parameters t1 and t2 are introduced to flexibly control the form of the asymmetric distribution loss function and improve the performance of the algorithm. In addition, its nonlinear clustering formation is also provided by using the kernel trick. Some experiments on noise-corrupted benchmark UCI and artificial datasets have been provided, and the detailed comparison results show that the proposed ADPC has better performance on most datasets. Further experiments and analysis on the face clustering have been done to demonstrate the effectiveness and feasibility of the proposed ADPC.

Secondary flow and thermal field dynamics in a T-junction with an upstream elbow: A POD-aided, eddy-sensitized Reynolds-stress modeling study

The thermal mixing of the flow-crossing streams in a T-shaped pipe junction configuration with the main branch inflow forming an elbow is presently simulated by applying a RANS-based eddy-resolving model of turbulence. The low-temperature main stream enters the T-junction with a Reynolds number of Rem=107893 after passing through a 90o-turned elbow located upstream. The high temperature branch stream is injected perpendicularly into the main stream at a Reynolds number of Rem=5422. A significant difference between the flow velocities of the two streams leads to the formation of a characteristic mixing process resembling a reattached jet configuration. Of particular interest is the interference of the branch flow with the main flow characterized by secondary vortices – the so – called Dean vortices, that are convected from the curved main inlet generating a low-rank mixing structures in its wake. The reference LES-based (Large-Eddy Simulation) database is provided by Tunstall et al. (2016). The computational framework relying on the scale-adaptive turbulence modeling approach, introduced principally by Menter and Egorov (2010), is used to simulate the dynamics of large-scale turbulent structures with moderate spatial and temporal resolution requirements. The motion of unresolved subscale structures is described by an appropriately sensitized differential near-wall Reynolds stress model according to Jakirlić and Maduta (2015). In addition, Proper-Orthogonal Decomposition (POD) is used to analyze the prevailing flow and thermal field mechanisms. The results obtained show a reasonable level of agreement with the LES reference, both from the standpoint of first-order statistics and spectral reproduction of the dynamics of coherent structures.

Probabilistic Slope Stability Analysis of Mount St. Helens Using Scoops3D and a Hybrid Intelligence Paradigm

In the past, numerous stratovolcanoes worldwide witnessed catastrophic flank collapses. One of the greatest risks associated with stratovolcanoes is a massive rock failure. On 18 May 1980, we witnessed a rock slope failure due to a volcano eruption, and a 2185.60 m high rock slope of Mount St. Helens was collapsed. Thus, from the serviceability perspective, this work presents an effective computational technique to perform probabilistic analyses of Mount St. Helens situated in Washington, USA. Using the first-order second-moment method, probability theory and statistics were employed to map the uncertainties in rock parameters. Initially, Scoops3D was used to perform slope stability analysis followed by probabilistic evaluation using a hybrid computational model of artificial neural network (ANN) and firefly algorithm (FF), i.e., ANN-FF. The performance of the ANN-FF model was examined and compared with that of conventional ANN and other hybrid ANNs built using seven additional meta-heuristic algorithms. In the validation stage, the proposed ANN-FF model was the best-fitted hybrid model with R2 = 0.9996 and RMSE = 0.0042. Under seismic and non-seismic situations, the reliability index and the probability of failure were estimated. The suggested method allows for an effective assessment of the failure probability of Mount St. Helens under various earthquake circumstances. The developed MATLAB model is also attached as a supplementary material for future studies.

On general weighted cumulative residual extropy and general weighted negative cumulative extropy

In this paper, we define general weighted cumulative residual extropy (GWCRJ) and general weighted negative cumulative extropy (GWNCJ). We obtain simple estimators for complete and right censored data. We obtain some results on GWCRJ and GWNCJ. We establish its connection to reliability theory and coherent systems. We also propose empirical estimators of GWNCJ. GWCRJ based on first-order statistics has been studied. Proposed estimators are calculated through data analysis. A new test of uniformity is proposed and analysed based on GWNCJ.

Dynamic Service Chaining for Ultra-Reliable Services in Softwarized Networks

Network softwarization is a paradigm shift for the next generation of network. Network Function Virtualization (NFV) softwarizes network functions as virtual network function (VNF) instances on top of a network infrastructure. Along with the merits of flexibility, programmability and reduced function provisioning cost, softwarization of network functions introduces new challenges of service’s reliability due to possible hardware failures, software bugs and hacker attacks. Currently reliable service provisioning schemes based on first-order statistics fails in accounting for the ultra-reliable needs of mission-critical services. In this paper, we propose a dynamic service chaining (DSC) framework to provision ultra-reliable services where the reliability is characterized by the probability distribution using extreme value theory. Our design objective is to minimize the number of backup VNF modules subject to reliability and resource constraints. Due to the dynamic nature of network, primary and backup VNFs are re-mapped to higher reliable physical machines in order to provide ultra-reliable services. Using Lyapunov stochastic optimization, primary VNF mapping and backup VNF selection are performed in the large and small timescales respectively. Numerical results show that the proposed DSC framework can guarantee ultra-reliable network services efficiently.

An automatic texture feature analysis framework of renal tumor: surgical, pathological, and molecular evaluation based on multi-phase abdominal CT.

To determine whether the texture feature analysis of multi-phase abdominal CT can provide a robust prediction of benign and malignant, histological subtype, pathological stage, nephrectomy risk, pathological grade, and Ki67 index in renal tumor. A total of 1051 participants with renal tumor were split into the internal cohort (850 patients from four different hospitals) and the external testing cohort (201 patients from another local hospital). The proposed framework comprised a 3D-kidney and tumor segmentation model by 3D-UNet, a feature extractor for the regions of interest based on radiomics and image dimension reduction, and the six classifiers by XGBoost. A quantitative model interpretation method called SHAP was usedto explore the contribution of each feature. The proposed multi-phase abdominal CT model provides robust prediction for benign and malignant, histological subtype, pathological stage, nephrectomy risk, pathological grade, and Ki67 index in the internal validation set, with the AUROC values of 0.88 ± 0.1, 0.90 ± 0.1, 0.91 ± 0.1, 0.89 ± 0.1, 0.84 ± 0.1, and 0.88 ± 0.1, respectively. The external testing set also showed impressive results, with AUROC values of 0.83 ± 0.1, 0.83 ± 0.1, 0.85 ± 0.1, 0.81 ± 0.1, 0.79 ± 0.1, and 0.81 ± 0.1, respectively. The radiomics feature including the first-order statistics, the tumor size-related morphology, and the shape-related tumor features contributed most to the model predictions. Automatic texture feature analysis of abdominal multi-phase CT provides reliable predictions for multi-tasks, suggesting the potential usage of clinical application. The automatic texture feature analysis framework, based on multi-phase abdominal CT, provides robust and reliable predictions for multi-tasks. These valuable insights can serve as a guiding tool for clinical diagnosis and treatment, making medical imaging an essential component in the process. • The automatic texture feature analysis framework based on multi-phase abdominal CT can provide more accurate prediction of benign and malignant, histological subtype, pathological stage, nephrectomy risk, pathological grade, and Ki67 index in renal tumor. • The quantitative decomposition of the prediction model was conducted to explore the contribution of the extracted feature. • The study involving 1051 patients from 5 medical centers, along with a heterogeneous external data testing strategy, can be seamlessly transferred to various tasks involving new datasets.

High-order paired-ASPP for deep semantic segmentation networks

Current semantic segmentation models only exploit first-order information, while rarely exploring high-order semantics. However, traditional first-order statistics are insufficient to support a solid unanimous representation. In this paper, we propose High-Order Paired-ASPP (Atrous Spatial Pyramid Pooling) Network to exploit high-order statistics from various feature levels. The network first introduces a High-Order Representation module to extract the contextual high-order information from all stages of the backbone. They can provide more semantic clues and discriminative information than the first-order ones. Besides, a Paired-ASPP module is proposed to embed high-order statistics of the early stages into the last stage. It can further preserve the boundary-related and spatial context in the low-level features for final prediction. Our experiments show that the high-order semantics significantly boost the performance on confusing objects. Our method achieves competitive performance without bells and whistles on three benchmarks, i.e., Cityscapes, ADE20K and Pascal-Context.

Predicting Drug Treatment Outcomes in Childrens with Tuberous Sclerosis Complex-Related Epilepsy: A Clinical Radiomics Study.

Highly predictive markers of drug treatment outcomes of tuberous sclerosis complex-related epilepsy are a key unmet clinical need. The objective of this study was to identify meaningful clinical and radiomic predictors of outcomes of epilepsy drug treatment in patients with tuberous sclerosis complex. A total of 105 children with tuberous sclerosis complex-related epilepsy were enrolled in this retrospective study. The pretreatment baseline predictors that were used to predict drug treatment outcomes included patient demographic and clinical information, gene data, electroencephalogram data, and radiomic features that were extracted from pretreatment MR imaging scans. The Spearman correlation coefficient and least absolute shrinkage and selection operator were calculated to select the most relevant features for the drug treatment outcome to build a comprehensive model with radiomic and clinical features for clinical application. Four MR imaging-based radiomic features and 5 key clinical features were selected to predict the drug treatment outcome. Good discriminative performances were achieved in testing cohorts (area under the curve = 0.85, accuracy = 80.0%, sensitivity = 0.75, and specificity = 0.83) for the epilepsy drug treatment outcome. The model of radiomic and clinical features resulted in favorable calibration curves in all cohorts. Our results suggested that the radiomic and clinical features model may predict the epilepsy drug treatment outcome. Age of onset, infantile spasms, antiseizure medication numbers, epileptiform discharge in left parieto-occipital area of electroencephalography, and gene mutation type are the key clinical factors to predict the epilepsy drug treatment outcome. The texture and first-order statistic features are the most valuable radiomic features for predicting drug treatment outcomes.

A robust radiomic-based machine learning approach to detect cardiac amyloidosis using cardiac computed tomography.

Cardiac amyloidosis (CA) shares similar clinical and imaging characteristics (e.g., hypertrophic phenotype) with aortic stenosis (AS), but its prognosis is generally worse than severe AS alone. Recent studies suggest that the presence of CA is frequent (1 out of 8 patients) in patients with severe AS. The coexistence of the two diseases complicates the prognosis and therapeutic management of both conditions. Thus, there is an urgent need to standardize and optimize the diagnostic process of CA and AS. The aim of this study is to develop a robust and reliable radiomics-based pipeline to differentiate the two pathologies. Thirty patients were included in the study, equally divided between CA and AS. For each patient, a cardiac computed tomography (CCT) was analyzed by extracting 107 radiomics features from the LV wall. Feature robustness was evaluated by means of geometrical transformations to the ROIs and intra-class correlation coefficient (ICC) computation. Various correlation thresholds (0.80, 0.85, 0.90, 0.95, 1), feature selection methods [p-value, least absolute shrinkage and selection operator (LASSO), semi-supervised LASSO, principal component analysis (PCA), semi-supervised PCA, sequential forwards selection] and machine learning classifiers (k-nearest neighbors, support vector machine, decision tree, logistic regression and gradient boosting) were assessed using a leave-one-out cross-validation. Data augmentation was performed using the synthetic minority oversampling technique. Finally, explainability analysis was performed by using the SHapley Additive exPlanations (SHAP) method. Ninety-two radiomic features were selected as robust and used in the further steps. Best performances of classification were obtained using a correlation threshold of 0.95, PCA (keeping 95% of the variance, corresponding to 9 PCs) and support vector machine classifier reaching an accuracy, sensitivity and specificity of 0.93. Four PCs were found to be mainly dependent on textural features, two on first-order statistics and three on shape and size features. These preliminary results show that radiomics might be used as non-invasive tool able to differentiate CA from AS using clinical routine available images.

Value of [18F]FDG PET/CT radiomic parameters in the context of response to chemotherapy in advanced cervical cancer

The first-order statistical (FOS) and second-order texture analysis on basis of Gray-Level Co-occurence Matrix (GLCM) were obtained to assess metabolic, volumetric, statistical and radiomic parameters of cervical cancer in response to chemotherapy, recurrence and age of patients. The homogeneous group of 83 patients with histologically confirmed IIIC1–IVB stage cervical cancer were analyzed, retrospectively. Before and after chemotherapy, the advancement of the disease and the effectiveness of the therapy, respectively, were established using [18F] FDG PET/CT imaging. The statistically significant differences between pre- and post-therapy parameters were observed for SUVmax, SUVmean, TLG, MTV, asphericity (ASP, p = 0.000, Z > 0), entropy (E, p = 0.0000), correlation (COR, p = 0.0007), energy (En, p = 0.000) and homogeneity (H, p = 0.0018). Among the FOS parameters, moderate correlation was observed between pre-treatment coefficient of variation (COV) and patients’ recurrence (R = 0.34, p = 0.001). Among the GLCM textural parameters, moderate positive correlation was observed for post-treatment contrast (C) with the age of patients (R = 0.3, p = 0.0038) and strong and moderate correlation was observed in the case of En and H with chemotherapy response (R = 0.54 and R = 0.46, respectively). All correlations were statistically significant. This study indicates the remarkable importance of pre- and post-treatment [18F] FDG PET statistical and textural GLCM parameters according to prediction of recurrence and chemotherapy response of cervical cancer patients.

Development of a new approach for rapid identification and classification of uranium ore concentrate powders using textural and spectroscopy signatures

Recently, a concept for a new approach for rapid identification of uranium ore concentrate (UOC) powders using colour, textural and spectroscopy signatures was developed using a sample dataset consisting of 79 industrial uranium ore concentrate powders produced by different production routes at different facilities. The samples were first grouped into six different predefined colour categories using a colour-based classification model previously developed. In this study, a machine learning approach was used to develop supervised texture- and spectroscopy-based classification models for each colour category of uranium ore concentrates.Scanning electron microscopy images of the UOC samples were collected at 100x, 250x, 500x/1000× magnifications. A total of 524 texture features describing sample morphology were extracted from each image using First Order Statistics (FOS), Grey Level Co-Occurrence Matrix (GLCM), Grey Level Run Length Matrix (GLRLM), Grey Level Size Zone Matrix (GLSZM), Locally Binary Pattern (LBP) and Angle Measure Technique (AMT) textural feature extraction algorithms. Hyperspectral images of the samples were collected in the wavelength range 900–1700 nm and the mean spectrum of each sample was calculated, giving the spectral features of the UOCs. The texture and spectral features were used as input to the machine learning approach which consisted of a feature reduction step to identify discriminatory features and a classification step to provide the texture- and spectroscopy-based models. An average prediction accuracy of 82% and 97% were obtained for the texture- and spectral-based classification models, respectively, on hold-out test sets. The feature reduction step identified two new nuclear forensics signatures, consisting of 3–7 texture (morphological) characteristics and 2–6 characteristic wavelengths, respectively.This new approach enables rapid classification of unknown uranium ore concentrate powders using only their textural and hyperspectral images. By combining the classification results from the two models, the most probable production process and chemical composition can be identified, and the provenience of the seized sample can be narrowed down to a few matching possibilities. Moreover, after the image acquisition, the models can provide results in less than 2 min speeding up the investigation procedure, a key factor when a nuclear security event occurs.

A New Breakpoint to Classify 3D Voxels in MRI: A Space Transform Strategy with 3t2FTS-v2 and Its Application for ResNet50-Based Categorization of Brain Tumors.

Three-dimensional (3D) image analyses are frequently applied to perform classification tasks. Herein, 3D-based machine learning systems are generally used/generated by examining two designs: a 3D-based deep learning model or a 3D-based task-specific framework. However, except for a new approach named 3t2FTS, a promising feature transform operating from 3D to two-dimensional (2D) space has not been efficiently investigated for classification applications in 3D magnetic resonance imaging (3D MRI). In other words, a state-of-the-art feature transform strategy is not available that achieves high accuracy and provides the adaptation of 2D-based deep learning models for 3D MRI-based classification. With this aim, this paper presents a new version of the 3t2FTS approach (3t2FTS-v2) to apply a transfer learning model for tumor categorization of 3D MRI data. For performance evaluation, the BraTS 2017/2018 dataset is handled that involves high-grade glioma (HGG) and low-grade glioma (LGG) samples in four different sequences/phases. 3t2FTS-v2 is proposed to effectively transform the features from 3D to 2D space by using two textural features: first-order statistics (FOS) and gray level run length matrix (GLRLM). In 3t2FTS-v2, normalization analyses are assessed to be different from 3t2FTS to accurately transform the space information apart from the usage of GLRLM features. The ResNet50 architecture is preferred to fulfill the HGG/LGG classification due to its remarkable performance in tumor grading. As a result, for the classification of 3D data, the proposed model achieves a 99.64% accuracy by guiding the literature about the importance of 3t2FTS-v2 that can be utilized not only for tumor grading but also for whole brain tissue-based disease classification.

Statistical properties of the integrated Stokes parameters of polarization speckle or partially polarized thermal light.

The Stokes parameters, observables in physics, cannot be measured at an ideal point or at an instant in time. This paper is devoted to investigating the statistical properties of the integrated Stokes parameters in polarization speckle or partially polarized thermal light. As an extension to previous study on integrated intensity, spatially integrated and temporally integrated Stokes parameters have been applied to study integrated and blurred polarization speckle and partially polarized thermal light. A general concept referred to as the numbers of degrees of freedom for the Stokes detection has been introduced to investigate the means and variances of the integrated Stokes parameters. The approximate forms of the probability densities functions of the integrated Stokes parameters are also derived to provide the entire first-order statistics of integrated and blurred stochastic phenomena in optics.