The purpose of this study was to evaluate the change of symptoms in COVID-19 patients over a ten-day period and their differences according to some characteristics. This retrospective epidemiological study was conducted using the records of all patients who were found to be positive for COVID-19 between September 2020 and November 2020 in Sivas. Of the 9985 COVID-19 cases, 4159 (41.7%) were between the ages of 19-40, 5327 (53.4%) were women, 9227 (93.4%) received outpatient treatment, 7019 (70.3%) had no chronic disease, 8552 (85.6%) were non-smokers. Headache, fever-chills, joint pain were the most common symptoms on the first day of disease, while cough, fatigue, and loss of smell were the most common on the tenth day. Headache, joint pain, fatigue, cough, waist-back pain, loss of smell/taste and runny nose were in forefront in the 19-40 age group. Fever-chills were more common in male, while many of the other symptoms were more common in female. Headache, throat ache, loss of smell/taste, and diarrhea were common in patients with no chronic disease. Cough, nausea-vomiting, and abdominal pain were predominant in non-smokers. Those at the young age group, female, those without chronic diseases and non-smokers can also develop COVID-19 symptoms.