The coronavirus disease (COVID-19) pandemic ruthlessly affected almost all aspects of human life—the industrial sector as well. Despite the severe effects of the pandemic on large-scale firms, the intensity of the impacts on them has not been uniform; different firms have been affected to different degrees. Using data enumerated from 102 large-scale firms in Nepal, this study has assessed the impact of the COVID-19 pandemic on large-scale firms and identified the factors moderating its impact on large-scale firms. The study revealed that the COVID-19 pandemic had negative impacts on the production, sales, and profit of large-scale firms in Nepal. The study disclosed that the age, sex, educational qualification, work experience, managerial skills and managerial foresight of the managers or higher authorities, age of the firm, total capital, type of ownership and sector of firms were the key factors moderating the impact of the COVID-19 pandemic on the large-scale firms. Policymakers are suggested to consider the factors such as age, sex, educational qualification, managerial skills, managerial foresight, age of the firm, total capital, type of ownership and sector of the firm while making policies related to improving the performance of large-scale firms during the pandemic like COVID-19 in the future. Int. J. Soc. Sc. Manage. Vol. 11, Issue-3: 66-75.