The high-precision machine tool’s dynamic, static, and rigid nature directly affects the machining efficiency and surface quality. Static and dynamic analyses are essential for the design and improvement of precision machine to ensure good tool performance under difficult and demanding machining conditions. In this study, the performance of a high-precision machine tool was analyzed using its virtual model created using CAD. Static and model analysis using ANSYS Workbench software was conducted to establish the tool's static deformation and static stiffness. Furthermore, the static and dynamic characteristics of the tool were explored using a finite element modeling approach to study their performance. In particular, the structure, static force, modal, frequency spectrum, and topology optimization of machine tools were primarily analyzed. Using model analysis, we found the first four different frequencies (22.5, 28.9, 40.6, and 47.4 Hz) and vibration type, which suggested of a weak link. Further static structural analysis revealed that the deformation of the spindle was 67.26 μm. An experimental static rigidity analysis was performed, and the experimental deformation values of the tool and spindle were obtained. The static and dynamic characteristics, as well as the accuracy and efficiency of the finite element model, were verified by comparing the data with the finite element analysis (FEA) results. Subsequently, we modified the settings and analysis model to ensure that the analysis results were consistent with the experimental findings. The error between the two results was within 1.56%. For an applied load of 5000 N on the spindle nose, the tool nose transient response was 0.5 s based on transient analysis. Under the condition that the structural deformation is as constant as possible, the lightweight structure may achieve the minimum weight and enhance the natural frequency; thus, the ideal structure will be obtained, and finite element analysis will then be performed. The optimal conditions for topology optimization include a lightweight structure, reduced structural deformation, and increased natural frequency of the structure. The developed method improves structural optimization, increases the ability of the product to be manufactured, and offers designers a variety of price-effective options.