The purpose of this study is to investigate the effect of fuel properties on liquid and vapor penetrations in evaporating spray systems. A recently developed model, which can simultaneously account for the finite thermal conductivity, finite mass diffusivity and turbulence effects within atomizing multi-component liquid fuel sprays, is utilized for the numerical predictions. Two different multi-component fuels with different boiling temperatures, densities and other thermal properties are implemented in the KIVA-3V computational fluid dynamics (CFD) code to study the evaporation behaviors. A six-component surrogate fuel is used to emulate the relevant volatility property of the real diesel fuel, and a second bi-component fuel is chosen to represent a low boiling-temperature fuel. The numerical results are compared with the experimental data, and the representative results are obtained. For a lower density and lower boiling temperature fuel, the liquid penetration length is shorter. However, the vapor penetration lengths are not affected by the fuel type in terms of fuel volatility. Available experimental data are used for validation and appraisal of the multi-component evaporation model.