Lathe bed is one of the important parts of machine tool, and its performance will affect the final machining accuracy of the machine tool directly. A numerical control lathe produced by a machine tool plant was taken as the research object, the finite element analysis and optimization method of the Lathe bed were studied. First of all, the external load of the bed was analyzed, static performance finite element analysis of the bed was implemented, and the corresponding analysis results were obtained. Then, the evaluation methods were discussed, and the deformations of junction areas were studied. At the same time, its effect on the performance of machine tool could also be analyzed. Based on the topology optimization method, the conceptual model of Lathe bed could be acquired, and also the rationality of the existing machine tool structure was discussed. The finite element analysis and optimization method of Lathe bed were concluded, which are helpful to obtain the static characteristics of the Lathe bed accurately. Moreover, there is an important practical significance to design the Lathe bed reasonably and to promote the machine tools comprehensive performance.