Cranial reconstruction using implants is critical for protecting intracranial structures and restoring cerebral hemodynamics in cases of cranial defects caused by accidents, diseases or cancer. Patient-specific implants (PSIs) made from materials such as polyether-ether-ketone (PEEK), are required to be lightweight, high in strength and capable of mimicking the natural bone structure. Effective fastening mechanisms using the required number of fixture plates are essential for seamless integration between the PSI and the cavity of a defected skull for successful cranial reconstruction. This study explores the optimal number and shape of fixture plates required to join a Skull-PSI assembly, such that the overall weight of the PSI remains minimal, and to ensure that these assemblies do not fail when subjected to heavy external loads of 950 N. PEEK material was used for PSI, natural bone for the defected skull and Titanium Alloy (Ti-6Al-4 V) for the fixture plates. Conventional straight shaped fixture plates often require manual bending for correct fitment on the Skull-PSI curved surface, which increases a surgeon's time and effort. Curved shaped fixture plates were designed, to save on this time and effort and enhance the contact surface area with the Skull-PSI surface. Four, three and two numbered, straight and curved shaped fixture plates were investigated using Finite Element Analysis (FEA) techniques. Three numbered, curved shaped fixture plates were found to be optimal, to generate a 7-gram lightweight PSI that could successfully sustain external loads up-to 950 N without failure. Ultimately, these design improvements would benefit both patient and surgeon in aspects of surgery time and patient comfort.
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