ABSTRACT Four experiments involving 4,506 pigs were conducted to determine the effects of different commercial enzymes on the growth performance of growing-finishing pigs fed distillers dried grains with solubles (DDGS). All experiments were conducted in the same commercial swine research facility. Experiments 1 and 2 used corn- and soybean meal-based diets with 15% DDGS. A β-mannanase enzyme was used in Exp. 1, and a blend of enzymes that contained β-glucanase, cellulase, and protease activities was used in Exp. 2. There were no differences (P > 0.10) in ADG, ADFI, and G:F between pigs fed diets with added enzyme and pigs fed diets without enzyme in either experiment (ADG 1.00 vs. 1.01 kg/d, and G:F 0.408 vs. 0.408; ADG 0.94 vs. 0.94 kg/d, and G:F 0.424 vs. 0.421, in Exp. 1 and 2, respectively) In Exp. 3, diets containing 45 and 60% DDGS were fed with or without 2 commercial proprietary enzyme products designed for use in diets containing DDGS. Average daily gain (0.85 vs. 0.86 kg/d) and G:F (0.370 vs. 0.373) were not different (P > 0.10) among treatments. In Exp. 4, an enzyme product with bacterial endo-1,4-β-xylanase was evaluated in diets containing 30% DDGS. Average daily gain (0.82 vs. 0.82 kg/d) and G:F (0.391 vs. 0.387) were not different (P > 0.10) among treatments. Based on the results, the different enzymes evaluated in these experiments did not enhance finishing pig growth performance when diets contained varying levels of DDGS.