Peristomal skin complications are prevalent among patients with ostomies and significantly impact their quality of life. Ostomy care is crucial for patients with ostomies, as it ensures proper adhesion, and protects and reduces the peristomal skin complications. To assess the effectiveness of nail polish as a novel skin barrier and compare its performance with the commonly available ostomy barriers in the market. Phase I randomized control trial. A single trauma and surgery center. Forty patients who were hospitalized for ostomy implantation were enrolled. Twenty cases were included in each group. The use of nail polish as a baseplate was tested against the common ostomy pastes. Over a period of 6 months, the study enrolled 40 patients who required loop ileostomy and they were followed up for 8 weeks. Postoperative evaluation was performed by using the City of Hope-quality of life ostomy and SF-36 questionnaires, as well as physical examinations conducted 1 day after surgery and at 4 and 8 weeks after surgical treatment. Forty patients were included in the study. In all 3 time points, significant differences were observed in SF-36 scores, time, and costs spent on ostomy care. The intervention group experienced fewer peristomal skin complications (skin itching, redness, inflammation, and burning), and also skin allergies at the first and second time points (p < 0.05). Furthermore, none of the patients in either the intervention or control group experienced rare complications such as folliculitis, candidiasis, contact dermatitis, or pyoderma gangrenosum. Single institution. The utilization of nail polish as a baseplate reduces skin allergies, peristomal skin complications, and the time and financial resources spent on ostomy care. Furthermore, using nail polish has demonstrated promising results in patients' quality of life. Consequently, utilizing nail polish emerged as the preferred choice among study participants. See Video.