In the pharmaceutical field, nanoparticle formulation is an effective approach to improve the solubility of poorly water-soluble drugs. Spray drying is used for the synthesis of fine drug particles. The particle size obtained by spray drying generally depends on the size of the sprayed droplet. In this study, an emulsion spray drying method is proposed as a novel method for nanoparticle synthesis. Oil-in-water (O/W) nanoemulsions containing oil-soluble drugs were prepared. Spraying O/W emulsions could produce fine particles with the size of 122 nm. The particles obtained by emulsion spray drying were smaller than those obtained by spray drying without an emulsion. Furthermore, an Ouzo emulsion, which is a self-emulsification method, was investigated to improve the particle yield. The particles obtained by spray drying of the Ouzo emulsion had the size of 0.50 μm, which was smaller than those obtained without the Ouzo emulsion. Moreover, in-vitro dissolution tests were performed to evaluate the solubility of the obtained particles as well as the unprocessed drug powder. The particles obtained via spray drying of the Ouzo emulsions showed the highest dissolution rate. In summary, spray drying of O/W and Ouzo emulsions resulted in the production of fine drug particles.