The authors of the article studied the specifics of innovative behavior of enterprises depending on their size. This specificity was determined in accordance with the following areas of the company’s activities: personnel policy, search for sources of financing, search for market niches, production of innovative products (determined by the nature of the innovations produced and the level of innovative mobility), search for partners and contractors, placement of financial responsibility centers. In preparing the article, a system analysis methodology was used, based on a set of theoretical and empirical research methods, the key of which is the case-study method, based on the results of content analysis, as well as expert interviews and a questionnaire survey. The analysis showed that the qualitative results of the activities of small and medium-sized innovative businesses often have a greater impact on the economic development of the region than large ones. The results obtained during the study have both scientific and practical significance. At the level of regional authorities, understanding the specifics of the innovative behavior of entrepreneurial firms is important from the point of view of determining measures of state support for innovatively active enterprises.