There is now ample evidence that there are wide divergences in the outcome of treatment of cancer in different countries, regions and hospitals. This would suggest that available knowledge and know-how is not always applied to its full extent and the available numbers would indicate that important progress in overall outcome for the global population could be made, if state of the art treatment would be asked and given at the right time. The analysis of the reasons of such differences complex. After treatment efficacy of a new biological or technological development has been proven in clinical research, a complex process is required for a novelty to reach the whole patient population. Even major improvements have been shown to take up to 10 years to be applied and, as in cancer most progresses have been achieved in small steps, their diffusion can be expected to be even slower. Three main steps can be assessed: a treatment has to be available, needs prescription at the right time and has to be given in the correct form. The availability is dependent on decisions by the structures governing the health care system and these are influenced by political and financial arguments. The adequate prescription pattern is dependent from training and educational aspects, as well from the public as from the general practitioner, the non oncological specialist and the oncologist. The rapidly expanding body of knowledge has created very specific requirements for continued medical education and structural support for diffusion of information. Finally, the correct execution of a treatment, monitored by quality control, is an aspect which has only in the very recent years been identified in its full importance. This is linked with the fact that the complexity of cancer treatment has been rapidly increasing with the involvement of growing numbers of people and the implementation of more sophisticated treatment schedules. The whole of these elements are covered in the process of “quality assurance”, which is the responsibility of all bodies involved. The importance of the different aspects of this process can be illustrated with a number of specific examples.
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