Introduction. Facial rejuvenation is currently a trend in aesthetic medicine and dermatology. The supralabial region is an area with significant aging changes, and there are only a few options for aesthetic treatments to improve the appearance of the skin. Some of them are the application of botulinum toxin, cross - linked and non - cross - linked hyaluronic acid, and apparatus. Thus, it is recommended to use a combined approach when treating this area. A new procedure is presented using hybrid hyaluronic acid complexes for the bioremodeling of supralabial skin. Objective. This prospective, non - comparative, uncontrolled study brings together a series of Mexican patients who were administered intradermal stabilized hyaluronic acid hybrid complexes in the supralabial region to investigate the effectiveness and safety of their use in this area in a protocolized manner. Material and Methods. Three visits were made, and digital photographs were taken in each one. The doctor evaluated the degree of fine supralabial wrinkles. The patient assessed the degree of pain during the procedure, and the patient and the doctor evaluated the degree of satisfaction after the procedure. Likewise, an independent specialist, not involved in treating the patients, carried out an evaluation. Adverse events that occurred during the study were documented. Results. The supralabial rhytides scale score improved from 5.5 at the initial visit to 3.3 at the end of treatment. The patient's GAIS (global aesthetic improvement scale assessment) rating with the treatment outcome at the final visit was 1.4, indicating very good satisfaction. Likewise, the GAIS classification of the treating physician at the end of treatment was very satisfactory, with 1.6. Discussion. According to the ratings obtained from the treating physician (GAIS and Likert), the patient himself (GAIS), and the independent researcher (Likert), this study demonstrated aesthetic improvement in the supralabial rhytides. No adverse events were reported with the treatment. Conclusions. The supralabial rhytides scale can be treated with hybrid hyaluronic acid complexes because they remodel the extracellular matrix and stimulate the cells of the three layers of skin.