You have accessJournal of UrologyProstate Cancer: Detection and Screening IV1 Apr 20122064 HIGHEST QUARTILE OF PERCENTAGE OF POSITIVE CORES ON PROSTATE BIOPSY IS NOT CORRELATED WITH FINAL PATHOLOGIC OUTCOMES Joel Hillelsohn, A. Ari Hakimi, Steve K. Williams, Brandon B. Adler, Ilir Agalliu, Farhang Rabbani, and Reza Ghavamian Joel HillelsohnJoel Hillelsohn Bronx, NY More articles by this author , A. Ari HakimiA. Ari Hakimi Bronx, NY More articles by this author , Steve K. WilliamsSteve K. Williams Bronx, NY More articles by this author , Brandon B. AdlerBrandon B. Adler Bronx, NY More articles by this author , Ilir AgalliuIlir Agalliu Bronx, NY More articles by this author , Farhang RabbaniFarhang Rabbani Bronx, NY More articles by this author , and Reza GhavamianReza Ghavamian Bronx, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2229AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Percent positive cores (PPC) on a standard 12 core prostate biopsy has been previously demonstrated to correlate with pathologic tumor stage, Gleason score and tumor size. We sought to determine whether the highest quartile of PPC correlates with highest final tumor stage, Gleason score, and tumor volume compared to the remaining quartiles in a contemporary cohort of underserved urban patients. METHODS Retrospective chart review was performed of 330 patients who underwent a robotic radical prostatectomy (RRP) at a single institution. Of these, 258 patients had biopsies done at our institution with at least 12 cores. Demographic, clinical and pathologic outcomes were recorded. Patients were divided into four quartiles, ANOVA and Chi-squared tests were used when appropriate. Spearman's correlation was used to compare PPC to final tumor stage, Gleason score and tumor volume. RESULTS There was no significant difference between the quartiles with respect to age, race or BMI. Mean pre-operative PSA, number of patients who received adjuvant hormone therapy or radiation therapy were similar between the groups. Overall, PPC was weakly correlated with final Gleason score and tumor stage (r=0.22, p<0.001, r=0.21, p<0.001 respectively) and strongly correlated with final tumor volume (r=0.47, p<0.001). The highest quartile (75 percentile - PPC> 42%) did not correlate with final tumor stage and tumor volume (r=−0.12, p=0.34, r=<0.001, p=0.96 respectively) and had a weak but not-significant correlation with final Gleason score (r=0.21, p=0.09). At an average follow up of 11.1 months, biochemical recurrence, or use of adjuvant therapy occurred no differently in the highest quartile compared to the remaining quartiles (p=0.37). CONCLUSIONS Although overall PPC correlates with final Gleason score, stage and tumor volume, at the highest quartile this correlation no longer exists. Therefore, urologists should use caution when using PPC alone to classify a patient's risk profile for treatment. Patient Demographics Percent Core Positive (quartiles) 0-25 25-50 50-75 75-100 p= n= 66 65 60 67 Age ± SD 61±6.4 60±7 59±7.9 60±7.5 0.74 Mean Preoperative PSA ± SD 7.4±4.7 9.4±11 9.7±11 8.8±8.5 0.75 Mean Biopsy Gleason Score ± SD 6.4±1 6.6±1.2 6.9±0.66 6.8±0.5 <0.01 Mean Gland Size ± SD 66.2±34 53±25 51±18 55±32 0.03 Positive Margins 10 21 26 30 <0.01 Biochemical Recurrence (%) 9(15%) 8(13%) 12(21%) 13(20%) 0.54 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e833 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joel Hillelsohn Bronx, NY More articles by this author A. Ari Hakimi Bronx, NY More articles by this author Steve K. Williams Bronx, NY More articles by this author Brandon B. Adler Bronx, NY More articles by this author Ilir Agalliu Bronx, NY More articles by this author Farhang Rabbani Bronx, NY More articles by this author Reza Ghavamian Bronx, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...