Final Result Research Articles

EPK-CLIP: External and Priori Knowledge CLIP for action recognition

Contrastive Language-Image Pretraining (CLIP) models have achieved significant success and have markedly improved the performance of various downstream tasks, including action recognition. However, how to effectively introduce knowledge into the field of action recognition remains an open question. In this work, an External and Priori Knowledge CLIP (EPK-CLIP) is proposed to introduce external knowledge into the model. To capture external knowledge, an external knowledge embedding module is proposed, which can generate and utilize human-object interaction relations as external knowledge, enabling the model to learn better features. Furthermore, the sparse regularization is introduced in the loss function, endowing the model with the ability to exploit the sparse priori knowledge inherent in the classification task. Finally, multiple inference module is proposed to obtain classification results from both direct and indirect perspectives. Specifically, the final classification result is obtained by fusing the outputs of different reasoning modules. Moreover, four external knowledge datasets: Kinetics-400-VC, Jester-VC, HMDB-51-VC, and UCF-101-VC are built and released for public usage, which is a multimodal extension of corresponding action datasets respectively. Under fully-supervised settings, our model achieves the top-1 accuracy of 84.3%, 97.1%, 82.9%, and 98.2% on Kinetics-400, Jester, HMDB-51, and UCF-101, respectively. In zero-shot experiments, our model also achieves state-of-the-art results, with top-1 accuracy of 51.6% and 77.7% on HMDB-51 and UCF-101, respectively. All related datasets and code can be found at https://github.com/geek12138/EPK-CLIP.

A multi-scale fuel cell degradation prediction method based on isometric convolution block and long short-term memory networks

Performance degradation prediction is considered an effective method to enhance the durability of Proton Exchange Membrane Fuel Cells (PEMFCs). However, accurate prediction under dynamic conditions remains a challenge. The MSD-ICB-LSTM model is proposed to improve the accuracy of the performance degradation prediction, which incorporates the information from both long-term and short-term modes within the PEMFC history operating data. Firstly, redundant variables are removed from the data, and the noise is eliminated using locally weighted scatterplot smoothing (LOWESS) to raise the quality of the input samples. Secondly, the Multi-Scale Decomposition (MSD) method is used to decompose the pre-processed data into long-term and short-term modes. Thirdly, a combined module containing encoding, internal decomposition and a double-layer Isometric Convolution Block (ICB) is used to deeply explore the nonlinear degradation characteristics in the short-term mode, while a Long-Short-Term Memory Network (LSTM) is utilized to estimate the long-term mode. The final result of prediction is obtained by combining the predictions of two modes. The experimental results show that the prediction accuracy of the proposed MSD-ICB-LSTM model is 99.74% in R2，and the Root Mean Square Error (RMSE) and Mean Absolute Percentage Error (MAPE) are 0.0034 and 0.77%, respectively. Thus, the method can efficiently explore the multi-scale features and enhance the accuracy of PEMFC performance degradation prediction.

Dimethyl Sulfoxide (DMSO) as a Potential Source of Interference in Research Related to Sulfur Metabolism-A Preliminary Study.

Dimethyl sulfoxide (DMSO), an organosulfur compound, is widely used as the gold standard solvent in biological research. It is used in cell culture experiments and as a component of formulations in in vivo studies. Unfortunately, parameters related to sulfur metabolism are often not taken into account when using DMSO. Therefore, in this work we aim to show that the addition of DMSO to the culture medium (even in amounts commonly considered acceptable) alters some parameters of sulfur metabolism. For this study, we used three cell lines: a commercially available Caco-2 line (HTB-37, ATCC) and two lines created as part of our early studies (likewise previously described in the literature) to investigate the anomalies of sulfur metabolism in mucopolysaccharidosis. As the negative effects of DMSO on the cell membrane are well known, additional experiments with the partial loading of DMSO into polymerosomes (poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide), PEG-PLGA) were performed to eliminate these potentially disruptive effects. The results show that DMSO is a source of interference in studies related to sulfur metabolism and that there are not just simple effects that can be corrected in the final result by subtracting control values, since complex synergisms are also observed.

Relationships between Organizational Culture, Organizational Commitment, and Organizational Citizenship Behavior

Organizations that are going to prosper and grow, particularly in the area of human resource management, must be able to recognize new opportunities in order to be ready for the future. The researcher is eager to look at the interactions between three important factors: organizational culture, organizational commitment, and organizational citizenship behavior, based on a survey of relevant literature. Organizational culture is the social glue that keeps workers united and fosters a feeling of community within the company. Previous research has shown that indicators of organizational success are significantly impacted by organizational commitment. An organization’s efficacy can also be significantly increased by practicing organizational citizenship. Current study indicates that employees’ organizational commitment is positively impacted by organizational culture. Furthermore, the results demonstrated that organizational culture has a discernible impact on organizational citizenship behavior. Based on the results of the aforementioned investigations, the researcher concludes that organizational commitment has a considerable impact on organizational citizenship behavior. The study’s results, according to the researcher, should eventually provide light on significant variables affecting organizational development. The final result of this study is that the researcher presents a model of the relationship between three important human resource factors: organizational culture, organizational commitment, and organizational citizenship behavior, as a guideline for organizational administration and human resource management development in the future.

Membrane/electrolyte interplay on ammonia motion inside a flow-cell for electrochemical nitrogen and nitrate reduction

Electrochemical ammonia production from molecular nitrogen and nitrate reduction reactions at ambient conditions has gained a lot of attention in recent years, making this topic more and more appealing. The race towards good and quick results in terms of Faradaic efficiency and productivity is not always focused on the possible source of ammonia contamination. In particular, Nafion membrane is the most commonly used in this field as cell separator, discarding the possible known disadvantages coming from ammonium ions absorption and release. The wettable microporous Celgard membrane has been proposed as a substitute for Nafion membranes, despite the separation mechanism, in this case, is only dimension-driven, so it does not assure ammonium ions retention. This paper reveals that the mechanism of ammonium ions absorption and release by Nafion 117 is strongly related to the cations present in the electrolyte and to a lesser extent by its pH value. On the other hand, Celgard membrane does not show any relevant ammonium ions absorption. Moreover, the different trend of ammonium ions motion from catholyte to anolyte solution inside a flow-cell reactor shows that none of the membranes is able to avoid ammonium ions crossover and that there is a correlation between the applied potential and the motion trend. Electrochemical nitrogen and nitrate reduction tests confirm how Nafion membrane can have a big impact on the final result of ammonium ions production, especially when dealing with low production quantities, leading to mistakes in the real quantity of ammonium ions coming from the reduction reaction.

EFEKTIVITAS SISTEM PELAYANAN RAKYAT SIDOARJO (SIPRAJA) SEBAGAI PELAYANAN PUBLIK DI DESA GEMPOLSARI KABUPATEN SIDOARJO

The Sidoarjo Regency Government presents innovative public service products based on electronic technology in the form of applications, namely the Sidoarjo People's Service System (SIPRAJA). This research aims to measure the effectiveness of SIPRAJA as a public service in Gempolsari Village, Sidoarjo Regency. The quantitative research method used is one variable in a descriptive approach based on the theory of innovation characteristics according to Rogers which requires a sample of 100 respondents. This research has the results that the indicators of relative superiority, compatibility, complexity, testability and observability are very effective. So, the overall conclusion is that the effectiveness of SIPRAJA in Gempolsari Village, Sidoarjo Regency with a final result of a percentage value of 69% is included in the very effective category.

A Differentially Private Framework for the Dynamic Heterogeneous Redundant Architecture System in Cyberspace

With the development of information technology, tremendous vulnerabilities and backdoors have evolved, causing inevitable and severe security problems in cyberspace. To fix them, the endogenous safety and security (ESS) theory and one of its practices, the Dynamic Heterogeneous Redundant (DHR) architecture, are proposed. In the DHR architecture, as an instance of the multi-heterogeneous system, a decision module is designed to obtain intermediate results from heterogeneous equivalent functional executors. However, privacy-preserving is not paid attention to in the architecture, which may cause privacy breaches without compromising the ESS theory. In this paper, based on differential privacy (DP), a theoretically rigorous privacy tool, we propose a privacy-preserving DHR framework called DP-DHR. Gaussian random noise is injected into each (online) executor output in DP-DHR to guarantee DP, but it also makes the decision module unable to choose the final result because each executor output is potentially correct even if it is compromised by adversaries. To weaken this disadvantage, we propose the advanced decision strategy and the hypersphere clustering algorithm to classify the perturbed intermediate results into two categories, candidates and outliers, where the former is closer to the correct value than the latter. Finally, the DP-DHR is proven to guarantee DP, and the experimental results also show that the utility is not sacrificed for the enhancement of privacy by much (a ratio of 4–7% on average), even in the condition of some executors (less than one-half) being controlled by adversaries.

3-point function of currents for holographic cosmology and monopole non-Gaussianities

In this paper we present the calculation of the three-point function in momentum space of currents for a SO(3) global symmetry, in a three-dimensional toy model within phenomenological holographic cosmology. Since the two-point function gives, via electric-magnetic duality, the resolution of the cosmological monopole problem, the three-point function is related to the monopole non-Gaussianities. We check that the final result is UV and IR finite and satisfies the transverse Ward identities and consider the k1 ≪ k2, k3 case, relevant for cosmology. We also show that the two-loop result for the 3-point function is completely independent of the explicit form of the potential, meaning that, like the solution to the monopole problem, also the non-Gaussianities are universal within the phenomenological holographic cosmology.

Integration of the Power Corridor Concept in the Early-Phase Design of Electric Naval Ships using Mathematical Design Models

The aim of this paper is to illustrate the process of identifying the ‘best compromise’ solution for an all-electric destroyer at the concept design level. The design strategy reflects a paradigm shift from a sequential approach towards a holistic multicriterial approach. The destroyer is required for an extensive range and endurance, fully operable in rough sea states. A mathematical design model (MDM) that includes a set of metamodels, is implemented to evaluate the overall performance of feasible, then non-dominated designs. The power corridor concept is integrated into the MDM to optimize the location and functionality of the individual units of the power train. The fuzzy sets theory is used for normalizing and weighing incommensurable properties of candidate designs, so resolving many of the ill-defined requirements and criteria. The final result of this study is a top-level specification for the destroyer with enhanced performance and reduced power demand.

Sistem Pendukung Keputusan Pemilihan Kepala Cabang SCO di JNE Menerapkan Kombinasi Metode Dematel dan Aras

The head of the SCO (Sales Counter Officer) branch is a person who has good experience, knowledge and skills to lead and process finances every day who offer products available from the goods delivery service at the JNE Ekpress company. The SCO branch head also plays a role in organizing and coordinating SCO workers on duty, starting from arranging shifts, taking work records, and minimizing losses caused by SCO input errors. Decision Support Systems are computer-based systems consisting of several components, namely language system components, knowledge system components and problem processing system components, which are interconnected with each other in making a decision. through the use of data and decision models in order to solve a problem. DEMATEL (Decision Making Trial And Evaluation Laboratory) aims to find direct (dependency) in a variable system. The Additive Ratio Assessment (ARAS) method is a method used for ranking criteria. In carrying out the ranking process, this method is very suitable for use in selecting candidates for SCO branch heads. Where the highest value is the best value of the final result. Based on the test results, it is known that Rahmad is a candidate who meets the criteria to become the new SCO branch head with a score of 0.957972 or 96%.

A hybrid quantum ensemble learning model for malicious code detection

Quantum computing as a new computing model with parallel computing capability and high information carrying capacity, has attracted a lot of attention from researchers. Ensemble learning is an effective strategy often used in machine learning to improve the performance of weak classifiers. Currently, the classification performance of quantum classifiers is not satisfactory enough due to factors such as the depth of quantum circuit, quantum noise, and quantum coding method, etc. For this reason, this paper combined the ensemble learning idea and quantum classifiers to design a novel hybrid quantum machine learning model. Firstly, we run the Stacking method in classical machine learning to realize the dimensionality reduction of high-latitude data while ensuring the validity of data features. Secondly, we used the Bagging method and Bayesian hyperparameter optimization method applied to quantum support vector machine (QSVM), quantum K nearest neighbors (QKNN), variational quantum classifier (VQC). Thirdly, the voting method is used to ensemble the predict results of QSVM, QKNN, VQC as the final result. We applied the hybrid quantum ensemble machine learning model to malicious code detection. The experimental results show that the classification precision (accuracy, F1-score) of this model has been improved to 98.9% (94.5%, 94.24%). Combined with the acceleration of quantum computing and the higher precision rate, it can effectively deal with the growing trend of malicious codes, which is of great significance to cyberspace security.

Abstract PO5-21-07: Mitomycin: its developmental role in the treatment of patients with BRCA - associated triple-negative early and locally advanced breast cancer

Abstract Rationale. BRCA-associated triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with high sensitivity to chemotherapy, which leads to increased interest in the development of new strategies for neoadjuvant treatment of patients with a triple-negative tumor phenotype. The aim of the study is to determine the role of adding platinum to standard neoadjuvant systemic therapy in patients with primary BRCA-associated TNBC, to evaluate the effect of platinum preparations on relapse-free survival in patients of this category, to determine the role of adding mitomycin to platinum in patients with primary BRCA-associated TNBC. Materials and methods. The study included 80 patients diagnosed with primary BRCA - associated TNBC, divided into 3 groups according to the treatment. Each group was subdivided depending on the final pathomorphological result and the presence of relapses. Results. 80 patients with primary BRCA-associated TNBC were divided into 3 groups depending on the ongoing neoadjuvant chemotherapy (NACT). Group I included 48 (60%) patients who received the AC-T regimen, in group II — NAC according to the AC-TCarb regimen, 27 (33.75%) patients, in group III — NAC with mitomycin in combination with cisplatin, 5 (6.25%) of patients. A comparative analysis of the results of the frequency of achieving complete pathomorphological regression (pCR), depending on the addition of a platinum drug to standard NAC, showed the advantage of group II compared to group I (73.7% vs. 41.2%, respectively, p = 0.0433). Taking into account the ongoing NAC regimens, with a median follow-up of 20.7 months, patients of group I had a slightly higher risk of relapse compared to patients of group II (p = 0.099). Patients of group III demonstrated the achievement of pCR in 66.6% of cases (2/3) during the full course of NAC, 2 patients of group III did not complete the planned course of NAC for medical reasons, due to the development of a pronounced nephrotoxic effect. During the observation period of group III, no cases of relapse were recorded. Conclusions.The addition of platinum drugs to the standard anthracycline/taxane NAPCT regimen in patients with primary BRCA-associated TNBC, results in a higher pCR rate, which entails a reduced risk of disease recurrence.The use of the new NAC regimen with mitomycin in combination with platinum compounds has promising results in patients with this oncopathology, which deserves a more detailed clinical evaluation.Performinga full course of planned NAC has a positive tendency in achieving pCR in patients of this category. Keywords: BRCA1/2 mutation; triple negative breast cancer; platinum preparations; mitomycin; neoadjuvant chemotherapy. Citation Format: Petr Krivorotko, Evgeniy Imyanitov, Diana Enaldieva, Elena Zhiltsova, Roman Donskih, Anna Sokolenko, Laysan Shaikhelislamova, Larisa Gigolaeva, Tengiz Tabagua, Alexander Komyakhov, Kirill Nikolaev, Konstantin Zernov, Sergey Yerechshenko, Roman Pesotsky, Nikolay Amirov, Alexander Emelyanov, Viktoria Mortada, Yana Bondarchuk, Vladislav Semiglazov. Mitomycin: its developmental role in the treatment of patients with BRCA - associated triple-negative early and locally advanced breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-21-07.

Mutual Inductance Identification and Bilateral Cooperation Control Strategy for MCR-BE System

Considering that the excitation method of an electric excitation synchronous motor has the disadvantages of the brush and slip ring, this article proposes a new brushless excitation system, which includes two parts: a wireless charging system and a motor. To meet the requirements of maximum transmission efficiency and constant voltage output of the system, a bilateral cooperation control strategy is proposed. For the strategy, the buck converter in the receiving side of the system can maintain maximum transmission efficiency through impedance matching, while the inverter in the transmitting side can keep the output voltage constant through phase shift modulation. In the control process, considering that the offset of coupling coils will affect the control results, a grey wolf optimization–particle swarm optimization algorithm is proposed to identify mutual inductance. Simulation and experimental results show that this identification algorithm can improve the identification accuracy and maximize the avoidance of falling into local optima. The final experimental result shows that the bilateral cooperation control strategy can maintain the output voltage around 48 V and the transmission efficiency around 84.5%, which meets the expected requirements.

HIGH-RISK HPV TYPES AND PATHOLOGY RESULTS IN PATIENTS WITH HIGH-RISK HPV POSITIVE

Aim: We aimed to analyses the high-risk HPV type distribution and pathology results in high-risk HPV positive patients. Materials and Methods: The research was retrospectively conducted and data was obtained from a tertiary gynecologic oncology colposcopy outpatient clinic. From September 2019 to December 2022, data from 3546 patients who tested positive for HPV and underwent colposcopic examination were analyzed. All patients granted the institution explicit permission to utilize their clinical data. Results: A total of 3546 patients with a median age of 40 years (range, 18–77 years) were analysed. Patient’s HPV status was; 1169 (33%) patients were HPV 16, 343 (9.7%) patients were HPV 18, and 2318 (65.4%) patients were HPV others. The detailed HPV positive results of patients were that 888 (25.4%) patients were only HPV 16, 197 (5.6%) patients were only HPV 18, and 2097 (59.9%) patients were only HPV others. In the study cohort, 529 (14.9%) patients had CIN 2+ lesions. HPV 16 and/or HPV 18 were detected in 331 (62.5%) of 529 patients with CIN 2+ lesions. The final pathology result of 507 (14.3%) patients was CIN 2/3 and of 22 (0.6%) patients was cancer. Conclusion: In conclusion, we found that while HPV other types were positive in two-thirds of the patients, HPV 16 and/or 18 were positive in more than four-fifths of the cancer cases. In the high-risk HPV positive patient group, HPV type can be used as a criterion when referring the patient to colposcopy

Abstract PO4-14-02: Enhancing Informative Outcomes with Liquid Biopsy in a Real-World Population of Patients with Advanced Breast Cancer: Analysis of the SOLTI-1903 HOPE Study

Abstract Background: The integration of next-generation sequencing (NGS) into routine clinical practice is often hindered by financial and logistical challenges, resulting in diagnostic and therapeutic disparities among patients. Addressing these issues, the SOLTI-1903 HOPE study (NCT04497285) seeks to evaluate the feasibility of implementing a molecular screening program that actively involves patients with advanced breast cancer (ABC) in the management of their disease. By empowering patients, this study aims to gain a comprehensive understanding of the genomic landscape of ABC and to facilitate patient access to matched targeted therapies in Spain Methods: In the SOLTI-1903 HOPE study, a patient-centric approach was adopted, allowing patients living anywhere in Spain, and diagnosed with ABC, to actively lead their inclusion, participation, and follow-up using a digital tool (DT). Patients signed an informant consent, and then provided clinical information and underwent a liquid biopsy (LBx) using the Guardant360 panel at a local laboratory. LBx samples could be obtained at the moment of progressive disease (PD), when a new line of treatment was started < 8 weeks before extraction (PT), or during treatment with stable disease o partial response lasting more than 8 weeks (SD/PR). Clinical and molecular findings were evaluated by a Molecular Advisory Board (MAB), which generated a comprehensive report explaining the observed alterations and listing potentially beneficial matched targeted treatments. The primary endpoint of this subanalysis was to compare the genomic outcomes between LBx samples obtained at SD and those obtained at PD or PT. In the study, tissue samples were also collected and analysed by Foundation but this analysis will be reported in other communications. Results: From October 2020 to May 2023, a total of 273 blood samples were obtained from 253 patients diagnosed with ABC, with the majority being HR+/HER2- (81%), followed by HER2-positive (13%) and triple-negative (6%). Mean turnaround time was 10.9 days from blood collection to final result. Despite nearly 40% of patients being SD or PR, in 79.9% of the LBx (n=218), one or more genomic alterations were detected, and among these, 74.0% (n=202) were classified as pathogenic. Among the 74 genes analyzed by the Guardant360 panel, 8 genes were classified as tiers I-III according to the ESCAT levels of clinical relevance. In 150 LBx samples (54.9%), one or more pathogenic alterations were associated with ESCAT levels I-III, while only the remaining 52 LBx samples (19.1%) with pathogenic alterations were not associated with any ESCAT levels I-III. Among the analyzed LBx samples, a total of 928 distinct gene alterations were identified. Of these, 650 alterations (70.1%) were classified as pathogenic, while 278 (29.9%) were categorized as variants of unknown significance or lacked a reported impact. Notably, 25% (n=323) of the pathogenic gene alterations were further classified as ESCAT I-III. Out of the 273 LBx samples, 140 were obtained at PD, 30 at PT, and 103 at SD/PR. Circulating tumor DNA (ctDNA) was detected in 91.4% of PD samples, 86.7% of PT samples, and 62.1% of SD/PR samples (p< 0.001). Alterations classified as ESCAT levels I-III were observed in 70% of PD samples, 60% of PT samples, and 33% of SD/PR samples (p< 0.001). In 20 patients, LBx was repeated, with 16 of them having the first LBx obtained during SD/PR and the second LBx collected during PD or PT. The detection rate of ctDNA increased significantly from 18.7% (n=3) to 87.5% (n=14) (p< 0.001). The number of LBx samples with ESCAT levels I-III alterations also showed a significant increase from 12.5% (n=2) to 68.7% (n=11) (p=0.0032). Conclusions: Our findings highlight the importance of obtaining LBx samples during disease progression -compared to SD/PR- to gain greater genomic informativeness and better guide personalized treatment approaches for patients with advanced breast cancer. Citation Format: Tomás Pascual, Elia Seguí, Ruben Olivera-Salguero, Juan Miguel Cejalvo, Mafalda Oliveira, Pablo Tolosa, Maria Vidal, Marcos Malumbres, Joaquín Gavilá, Cristina Saura, Sonia Pernas, Rafael López, Mireia Margelí, Judith Balmaña, Montserrat Muñoz, Isabel Blancas, Valentina Boni, Eva Ciruelos, Elena Galve, Antonia Perelló, Rodrigo Sánchez-Bayona, Susana De La Cruz, Miguel De La Hoya, Aura Blanch-Torras, Rosana Sposito, Jordi Canes, Helena Masanas, Rosa Olmos, Margarita Forns, Maria José Prieto, Ana Casas, Aleix Prat. Enhancing Informative Outcomes with Liquid Biopsy in a Real-World Population of Patients with Advanced Breast Cancer: Analysis of the SOLTI-1903 HOPE Study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-14-02.

Gribov problem in the eletroweak and gluon confined theories

We show that gauge fields after a spontaneous symmetry breaking (SSB) mechanism do not have a Gribov problem along the broken directions. In order to make this proof, we describe a gauge fixing procedure inspired on Morse’s theory leading to the concept of a gauge fixing generating functional. This approach is specially suited in order to understand the unitary gauges of ’t Hooft. The conclusion is that after a SSB process, the generalized Faddeev-Popov operator acquires a positive definite value along the broken directions. We show how this works in the eletroweak SU(2)XU(1) theory, where such a result is in fact expected as in this case the gauge fields acquire masses after the SSB. Then we apply this development to the SL(3,c) confining model of Amaral [A path to confine gluons and fermions through complex gauge theory, ]. The final result explains why such confining mechanism is actually a solution to the Gribov problem for the confined gauge fields. These cases show that although confinement is not a general effect of the solution of the Gribov problem, as we can infer from the eletroweak example, its solution indeed seems to be necessary in order to achieve confinement. In the end, these conclusions allow us to speculate that the strong interaction confinement may be the result of some hidden SSB mechanism yet to be described. Published by the American Physical Society 2024

Implementasi Sistem dalam Menghitung Transaksi dan Stok pada Proses Penjualan di Yamaha Anugerah Motor Berbasis Web

The rapid development of technology in the era of Industry 4.0 has made various internet uses essential to fulfill several needs. This includes systems that can assist in the business sector. With the advancement of technology, it greatly aids daily life. The research aims to develop a web-based application to calculate transactions and stock in business. This application can display information related to sales figures, reports, and data management of goods that are user-friendly for business practitioners. The system to calculate transactions and stock can be applied to assist the sales business process. It provides information about available items so that business practitioners can sell goods and view transaction data. This web-based system is operated through a website and uses the internet as a platform to manage and store available data. Researchers used qualitative field research methods to collect profile data and information about the current running systems as supporting elements in application development. For application design, researchers used Visual Studio Code software, which can be used to create websites using programming languages such as HTML, CSS, and JavaScript. The system development method applied is the prototype method. This method was chosen by researchers as it is suitable and meets the needs of the system to be developed. The final result of this research is a web-based application for calculating transactions and stock in the sales process at Yamaha Anugerah Motor. The designed application features displaying information about managing goods and categories, as well as conducting transactions that are directly recorded in sales reports. With this system, one can track transactions and stock levels. Data management for goods is computerized, and reports about transactions and stock can be printed easily. It also facilitates easy restocking of goods.

Effect of soaking time of cocoa fruit peel and addition of citronella grass extract (Cymbopogon nardus) on quality characteristics of infused water from indonesian local resources for increasing body immune to face bad environment

Infused water is a form of modern processed food that is widely consumed by the public. Infused water drinks can be made from a variety of food ingredients. This infused water drink is made from cocoa pod skin and added citronella juice. This research was conducted to investigate the impact of soaking duration of cocoa fruit peel and the concentration of lemongrass extract on the characteristics of cocoa fruit peel infused water. This study used a factorial Completely Randomized Design method with two factors, namely the soaking time of cocoa fruit peel (P): (2 hours; 4 hours; 6 hours) and the concentration of citronella grass extract (S): (5%; 10%, 15%). Infused water drinks were then analyzed for color index (°Hue), pH, vitamin C levels, and antioxidant activity. The final result was that P3S3 treatment = 6 hours of soaking cocoa pod skin : 15% citronella grass extract was the best treatment of infused water.

QLDTI: A Novel Reinforcement Learning-based Prediction Model for Drug-Target Interaction

Background: Predicting drug-target interaction (DTI) plays a crucial role in drug research and development. More and more researchers pay attention to the problem of developing more powerful prediction methods. Traditional DTI prediction methods are basically realized by biochemical experiments, which are time-consuming, risky, and costly. Nowadays, DTI prediction is often solved by using a single information source and a single model, or by combining some models, but the prediction results are still not accurate enough. Objective: The study aimed to utilize existing data and machine learning models to integrate heterogeneous data sources and different models, further improving the accuracy of DTI prediction. Methods: This paper has proposed a novel prediction method based on reinforcement learning, called QLDTI (predicting drug-target interaction based on Q-learning), which can be mainly divided into two parts: data fusion and model fusion. Firstly, it fuses the drug and target similarity matrices calculated by different calculation methods through Q-learning. Secondly, the new similarity matrices are inputted into five models, NRLMF, CMF, BLM-NII, NetLapRLS, and WNN-GIP, for further training. Then, all sub-model weights are continuously optimized again by Q-learning, which can be used to linearly weight all sub-model prediction results to output the final prediction result. Results: QLDTI achieved AUC accuracy of 99.04%, 99.12%, 98.28%, and 98.35% on E, NR, IC, and GPCR datasets, respectively. Compared to the existing five models NRLMF, CMF, BLM-NII, NetLapRLS, and WNN-GIP, the QLDTI method has achieved better results on four benchmark datasets of E, NR, IC, and GPCR. Conclusion: Data fusion and model fusion have been proven effective for DTI prediction, further improving the prediction accuracy of DTI.

Repetition of thyroid fine-needle aspiration cytology after an initial nondiagnostic result: Is there an optimal timing?

IntroductionIt is suggested to wait at least 3 months to repeat a fine needle aspiration cytology (FNAC) to avoid possible inflammatory cytological changes induced by a previous procedure. This study evaluated the influence of the interval between 2 FNACs in a cohort with a previous non-diagnostic (ND) FNAC. We analysed the occurrence of ND or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) results in the second FNAC, based on the intervals between procedures. Patients and methodsRetrospective study (2017–2020) including thyroid nodules with a ND result, subjected to another FNAC. Demographic, clinical and echographic data, interval between FNACs and their results were collected. We considered the intervals: ≤/>3 months and ≤/>6 months. Second FNAC results were classified as ND, AUS/FLUS or diagnostic (including the other Bethesda categories). ResultsIncluded 190 nodules (190 patients – 82.1% women, mean age 60±13.7 years) with a first ND FNAC. The second FNAC results were: ND in 63 cases, AUS/FLUS in 9 and diagnostic in 118 cases. There were no statistical differences in FNAC results performed≤3 months (13 ND, 2 AUS/FLUS, 19 diagnostic) vs >3 months (50 ND, 7 AUS/FLUS, 99 diagnostic; p=0.71). Similarly, there were no statistical differences considering a longer time interval: ≤6 months (32 ND, 3 AUS/FLUS, 59 diagnostic) vs >6 months (31 ND, 6 AUS/FLUS, 59 diagnostic; p=0.61). ConclusionsTime interval between FNACs was not relevant to the final cytological result. Early FNAC repetition did not increase the cases of ND or AUS/FLUS.