<h3>BACKGROUND CONTEXT</h3> Anterior lumbar interbody fusion (ALIF) is a less invasive approach to the lumbar spine when compared to posterior fusion that facilitates stabilization, indirect neural decompression and the option for circumferential fusion. However, ALIF may be complicated by interbody device or graft subsidence contributing to significant morbidity. While several studies have reported the incidence of subsidence in the setting of ALIF, there remains a paucity of literature analyzing specific risk factors that may predispose patients to this complication. <h3>PURPOSE</h3> This study sought to identify patient and procedural risk factors for subsidence in patients undergoing ALIF. <h3>STUDY DESIGN/SETTING</h3> Retrospective cohort. <h3>PATIENT SAMPLE</h3> Patients who underwent ALIF with a minimum of two years clinical and radiographic follow-up. <h3>OUTCOME MEASURES</h3> Subsidence, defined categorically as 2 mm or more interbody device migration into the adjacent vertebra. <h3>METHODS</h3> Preoperative and 6-week postoperative radiographs were used to measure disc space height and cage placement. Cage placement was measured as the center point ratio percentage defined as the distance of the cage midpoint from the posterior edge of the endplate divided by the endplate depth. Final postoperative radiographs were reviewed to measure subsidence and to assess for successful fusion. Patients were then grouped as non-subsidence (NS-ALIF) or cage subsidence (CS-ALIF). Demographic and radiographic variables were evaluated between groups to identify significant predictors on univariate statistics. Multinomial logistic regression was then employed to identify independent predictors of subsidence while retaining variables with a significance of p < .05 on univariate statistics. <h3>RESULTS</h3> A total of 144 patients who underwent ALIF at 170 levels were included for analysis. The average age of the cohort was 47.41±13.04 years, and average follow-up was 50.70±28.44 months (4.23 years). The overall incidence of subsidence was 22.94% (39/170 levels). On univariate statistics, the CS-ALIF group was significantly older (51.44±11.85 vs 46.60±13.13; p=.020), had a significantly higher BMI (31.97±4.38 vs 29.25±5.73; p=.048), worse ASA (p=.001), and a higher prevalence of comorbid osteoporosis (23.08% vs 3.82%; p <.001). Additionally, the interbody device was placed significantly more anteriorly in CS-ALIF patients as measured via the center point ratio (61.28±8.74% vs 56.80±9.76%; p=.005). On multivariate analysis, the center point ratio remained the only significant predictor for subsidence, with more anterior cage placement posing an increased risk (OR: 1.08, 95% CI: 1.03 - 1.14; p=.003). Further, the center point ratio contributed the most to the overall model fit, with a relative contribution of 52.6%, while osteoporosis contributed 14.8%, ASA 14.0%, age 10.9%, and BMI 7.7%. Receiver operating characteristic (ROC) curve analysis was determined a threshold value for the center point ratio of 56.98%, beyond which subsidence risk was increased. <h3>CONCLUSIONS</h3> Subsidence following ALIF occurred at a rate of 22.94%. Significant univariate risk factors for interbody cage subsidence included older age, higher BMI, severe ASA, osteoporosis, and an anteriorly placed cage (increased center point ratio). On multivariate analysis, increased center point ratio remained the only significant predictor of subsidence. Based on these findings, surgical technique should be focused on optimizing placement of the interbody cage and avoiding overstuffing of the disc space. Further investigation should validate these findings in an external cohort. <h3>FDA DEVICE/DRUG STATUS</h3> This abstract does not discuss or include any applicable devices or drugs.
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