You have accessJournal of UrologyPenile & Testicular Cancer I (MP40)1 Sep 2021MP40-01 NATIONAL TRENDS AND SURVIVAL OUTCOMES OF PENILE SQUAMOUS CELL CARCINOMA BASED ON HUMAN PAPILLOMAVIRUS STATUS Grant Pollock, Chiu-Hsieh Hsu, Ken Batai, Ava Wong, Alejandro Recio Boiles, Benjamin Lee, and Juan Chipollini Grant PollockGrant Pollock More articles by this author , Chiu-Hsieh HsuChiu-Hsieh Hsu More articles by this author , Ken BataiKen Batai More articles by this author , Ava WongAva Wong More articles by this author , Alejandro Recio BoilesAlejandro Recio Boiles More articles by this author , Benjamin LeeBenjamin Lee More articles by this author , and Juan ChipolliniJuan Chipollini More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002055.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There are no series evaluating penile squamous cell carcinoma (pSCC) based on human papillomavirus (HPV)-status. Herein, we present national registry data on clinical and survival outcomes for pSCC based on HPV. METHODS: We performed a retrospective review of 1,224 pSCC patients with known HPV-staining from the National Cancer Database. Patients with cM1 disease, did not receive treatment, and missing follow-up data were excluded. Logistic regression identified factors associated with locally aggressive disease. Univariable, multivariable and inverse probability of treatment weighting (IPTW)-Cox proportional hazards modeling were used to assess hazard ratios (HR) associated with overall survival (OS) with respect to HPV. RESULTS: After exclusion criteria, we identified 825 cases of which 321 (38.9%) were HPV-positive. The HPV-positivity rate did not significantly change by year. HPV-positive patients were younger, had lower Charlson-Deyo performance score, and resided in areas with both lower median household income and lower school education completion. HPV-positive tumors presented with lower American Joint Committee on Cancer clinical T-stage (cT), poorer differentiation, lower rates of lymphovascular invasion (LVI), and more node-positive disease (cN+). For those who underwent lymph node surgery (n=132), there were no differences in final pathologic stage, upstaging, or presence of extranodal extension. Only tumor differentiation, LVI, and performance score were independent predictors for locally-aggressive disease. HPV-status was not a predictor of OS (IPTW-HR:0.89, p=0.13). CONCLUSIONS: In the largest series evaluating pSCC based on HPV status, HPV-positive tumors were associated with lower cT stages, less LVI, but more cN+ disease. Etiologic classification based on HPV did not appear to impact survival. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e714-e714 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Grant Pollock More articles by this author Chiu-Hsieh Hsu More articles by this author Ken Batai More articles by this author Ava Wong More articles by this author Alejandro Recio Boiles More articles by this author Benjamin Lee More articles by this author Juan Chipollini More articles by this author Expand All Advertisement Loading ...