INTRODUCTION: Part of the workup for surgical management of epilepsy is stereotactic placement of intracranial depth electrodes to better understand the origin and network pattern of spread of seizures. To facilitate surgical decision making, epilepsy team discussion, and patient/family communication, a workflow was developed to create 3D printed models of sEEG patient brains and electrode locations which could be invaluable in explaining EEG results and surgical options. METHODS: Pre-op MRI and post-implantation CT scans of a sEEG case were imported and merged using 3D Slicer, a free and open-source software package for advanced medical imaging research.The CT was segmented to include only the high-density metallic electrodes. These 3D models were exported into Autodesk Fusion 360, a computer-aided design (CAD) program, where electrode models were designed based on their location on the CT scan. These models were exported to Maxon Zbrush to be cleaned and re-meshed to make the model easier to sculpt and manipulate.The electrode objects were used as cutting tools to create holes in the brain model. Finally, the relevant portion of the brain (right temporal lobe and surrounding regions) and electrodes were exported for 3D printing. The final models were 3D printed on a FormLabs Form 3 stereolithography (SLA) printer using clear resin for the brain and flexible grey resin for the electrodes. RESULTS: CONCLUSIONS: A workflow was devised to print anatomic models of brains implanted with electrodes for seizure monitoring in 2-3 days utilizing software from multiple disciplines including medical imaging, CAD/engineering, and 3D sculpting used in the film and video game industries. Future models will include further anatomical definition with more advanced 3D sculpting and printing techniques.