Soft adhesives used in cutting-edge technological fields are susceptible to shear fatigue failure under complex in-plane loadings. Although the interaction or coupling effect between creep and fatigue damage have been studied, the effect of the equivalent creep damage during typical fatigue loading on the fatigue life of soft adhesives, as well as the interaction between the equivalent creep damage and fatigue damage of soft adhesives have never been characterized. This study systematically investigates the creep-fatigue interaction of the soft adhesive under various loading conditions. It was found that significant equivalent creep damage occurs and accumulates under typical cyclic loading, which seriously accelerates the shear fatigue failure of soft adhesives. Furthermore, the contribution of the equivalent creep damage to the final shear fatigue failure is even more pronounced than the fatigue damage. The quantitative construction of creep-fatigue damage diagrams has led to the determination of strong creep-fatigue interaction, which could be understood by the interactive mechanism between the stretching, friction, pulling-out, and rupture of molecular chains. In light of the distinctive creep-fatigue interaction mechanism, a modified Chaboche damage model has been developed, which could accurately predict the shear fatigue life of soft adhesives under a wide range of loading conditions.